Successive Immunization With Epitope-Decreasing Dengue Antigens Induced Conservative Anti-Dengue Immune Responses

Successive Immunization With Epitope-Decreasing Dengue Antigens Induced Conservative Anti-Dengue Immune Responses

Repeated homologous antigen immunization has been hypothesized to hinder antibody diversification, whereas sequential immunization with heterologous immunogens can educate B cell differentiations towards conserved residues thereby facilitating the generation of cross-reactive immunity. In this study...

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Bibliographic Details
Main Authors: Jue Hou, Weijian Ye, Hooi Linn Loo, Lan Hiong Wong, Jianzhu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
dengue virus
vaccine development
sequential immunization
immunoglobulin diversification
epitope-decreasing
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.585133/full

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