Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry
The aim of the present study was to evaluate changes in cutaneous blood flow detected by incoherent optical fluctuation flowmetry (IOFF) in diabetic patients with diagnosed microangiopathies. The study includes 52 patients with type 2 diabetes mellitus (12 males, 40 females, median age 57 (51; 60) y...
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MDPI AG
2023-04-01
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| Online Access: | https://www.mdpi.com/2304-6732/10/4/442 |
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| author | Alexey Glazkov Ksenia Krasulina Polina Glazkova Andrey Tarasov Denis Lapitan Yulia Kovaleva Dmitry Rogatkin |
| author_facet | Alexey Glazkov Ksenia Krasulina Polina Glazkova Andrey Tarasov Denis Lapitan Yulia Kovaleva Dmitry Rogatkin |
| author_sort | Alexey Glazkov |
| collection | DOAJ |
| description | The aim of the present study was to evaluate changes in cutaneous blood flow detected by incoherent optical fluctuation flowmetry (IOFF) in diabetic patients with diagnosed microangiopathies. The study includes 52 patients with type 2 diabetes mellitus (12 males, 40 females, median age 57 (51; 60) years). All patients were examined using the IOFF method using functional tests: occlusion test on the index finger, local heat test on the dorsum of the foot, and local heat test on the big toe. The patients were divided into 2 groups: 13 patients with both diabetic retinopathy and diabetic nephropathy (Group 2, severe microcirculatory disorders) and 39 patients with only 1 microangiopathic complication or without any (Group 1). Local thermal hyperaemia (LTH2_1) was higher in Group 1 than in Group 2 (<i>p</i> = 0.011). Post-occlusive reactive hyperaemia (PORH_2) was higher in Group 2 than in Group 1 (<i>p</i> = 0.009). No changes were detected on the big toe. When PORH_2 and LTH2_1 were used in combination, the area under the ROC curve (95% CI) was 0.733 (0.62 to 0.846). Thus, the IOFF method has the potential to accurately detect blood flow abnormalities associated with diabetic microangiopathies. |
| first_indexed | 2024-03-11T04:37:06Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2304-6732 |
| language | English |
| last_indexed | 2024-03-11T04:37:06Z |
| publishDate | 2023-04-01 |
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| series | Photonics |
| spelling | doaj.art-37660ba6f69d415bbef076b02af4013a2023-11-17T20:58:07ZengMDPI AGPhotonics2304-67322023-04-0110444210.3390/photonics10040442Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation FlowmetryAlexey Glazkov0Ksenia Krasulina1Polina Glazkova2Andrey Tarasov3Denis Lapitan4Yulia Kovaleva5Dmitry Rogatkin6Moscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, RussiaMoscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, RussiaMoscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, RussiaMoscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, RussiaMoscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, RussiaMoscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, RussiaMoscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, RussiaThe aim of the present study was to evaluate changes in cutaneous blood flow detected by incoherent optical fluctuation flowmetry (IOFF) in diabetic patients with diagnosed microangiopathies. The study includes 52 patients with type 2 diabetes mellitus (12 males, 40 females, median age 57 (51; 60) years). All patients were examined using the IOFF method using functional tests: occlusion test on the index finger, local heat test on the dorsum of the foot, and local heat test on the big toe. The patients were divided into 2 groups: 13 patients with both diabetic retinopathy and diabetic nephropathy (Group 2, severe microcirculatory disorders) and 39 patients with only 1 microangiopathic complication or without any (Group 1). Local thermal hyperaemia (LTH2_1) was higher in Group 1 than in Group 2 (<i>p</i> = 0.011). Post-occlusive reactive hyperaemia (PORH_2) was higher in Group 2 than in Group 1 (<i>p</i> = 0.009). No changes were detected on the big toe. When PORH_2 and LTH2_1 were used in combination, the area under the ROC curve (95% CI) was 0.733 (0.62 to 0.846). Thus, the IOFF method has the potential to accurately detect blood flow abnormalities associated with diabetic microangiopathies.https://www.mdpi.com/2304-6732/10/4/442incoherent optical fluctuation flowmetry (IOFF)diabetes mellitusmicroangiopathymicrovascular reactivitylocal thermal hyperaemiapost-occlusive reactive hyperaemia |
| spellingShingle | Alexey Glazkov Ksenia Krasulina Polina Glazkova Andrey Tarasov Denis Lapitan Yulia Kovaleva Dmitry Rogatkin Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry Photonics incoherent optical fluctuation flowmetry (IOFF) diabetes mellitus microangiopathy microvascular reactivity local thermal hyperaemia post-occlusive reactive hyperaemia |
| title | Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry |
| title_full | Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry |
| title_fullStr | Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry |
| title_full_unstemmed | Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry |
| title_short | Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry |
| title_sort | detection of cutaneous blood flow changes associated with diabetic microangiopathies in type 2 diabetes patients using incoherent optical fluctuation flowmetry |
| topic | incoherent optical fluctuation flowmetry (IOFF) diabetes mellitus microangiopathy microvascular reactivity local thermal hyperaemia post-occlusive reactive hyperaemia |
| url | https://www.mdpi.com/2304-6732/10/4/442 |
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