Physical chemistry evaluation of stability, spreadability, in vitro antioxidant, and photo-protective capacities of topical formulations containing Calendula officinalis L. leaf extract
Calendula is used widely in cosmetic formulations that present phenolic compounds in their chemical constitution. The objective of our research was to develop and evaluate the stability of topical formulations containing 5% hydro-ethanolic extract of calendula leaves, including spreadability, and in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2015-03-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100063&lng=en&tlng=en |
| _version_ | 1811260407810097152 |
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| author | Viviane Cecília Kessler Nunes Deuschle Regis Augusto Norbert Deuschle Mariana Rocha Bortoluzzi Margareth Linde Athayde |
| author_facet | Viviane Cecília Kessler Nunes Deuschle Regis Augusto Norbert Deuschle Mariana Rocha Bortoluzzi Margareth Linde Athayde |
| author_sort | Viviane Cecília Kessler Nunes Deuschle |
| collection | DOAJ |
| description | Calendula is used widely in cosmetic formulations that present phenolic compounds in their chemical constitution. The objective of our research was to develop and evaluate the stability of topical formulations containing 5% hydro-ethanolic extract of calendula leaves, including spreadability, and in vitro photo-protective, and antioxidant capacity. To evaluate the stability, we used organoleptic characteristics, pH, and viscosity parameters. Antioxidant capacity was measured by the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, and the photo-protective capacity by SPF spectrophotometric measure. All formulations were stable. The calendula extract formulations in gel and cream showed no significant variations in pH, and the cream formulations presented lower viscosity variations than gel formulations. The spreadability of the gel formulations was superior to those in cream. The formulations also presented good antioxidant capacities and an FPS of around 1.75. In accordance with the results, the formulations can be used as antioxidants, but considering the low SPF obtained, calendula cannot be considered as a stand-alone sunscreen, yet may well be tested in future studies towards verifying enhancement of synthetic sunscreens. |
| first_indexed | 2024-04-12T18:46:56Z |
| format | Article |
| id | doaj.art-3766313934934d63b47204c40bc8fe03 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-12T18:46:56Z |
| publishDate | 2015-03-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-3766313934934d63b47204c40bc8fe032022-12-22T03:20:35ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902015-03-01511637510.1590/S1984-82502015000100007S1984-82502015000100063Physical chemistry evaluation of stability, spreadability, in vitro antioxidant, and photo-protective capacities of topical formulations containing Calendula officinalis L. leaf extractViviane Cecília Kessler Nunes DeuschleRegis Augusto Norbert DeuschleMariana Rocha BortoluzziMargareth Linde AthaydeCalendula is used widely in cosmetic formulations that present phenolic compounds in their chemical constitution. The objective of our research was to develop and evaluate the stability of topical formulations containing 5% hydro-ethanolic extract of calendula leaves, including spreadability, and in vitro photo-protective, and antioxidant capacity. To evaluate the stability, we used organoleptic characteristics, pH, and viscosity parameters. Antioxidant capacity was measured by the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, and the photo-protective capacity by SPF spectrophotometric measure. All formulations were stable. The calendula extract formulations in gel and cream showed no significant variations in pH, and the cream formulations presented lower viscosity variations than gel formulations. The spreadability of the gel formulations was superior to those in cream. The formulations also presented good antioxidant capacities and an FPS of around 1.75. In accordance with the results, the formulations can be used as antioxidants, but considering the low SPF obtained, calendula cannot be considered as a stand-alone sunscreen, yet may well be tested in future studies towards verifying enhancement of synthetic sunscreens.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100063&lng=en&tlng=enCalendula officinalis L./farmacognosiaFormulações tópicas/avaliação in vitroCalêndula/formulações tópicas/avaliação in vitro |
| spellingShingle | Viviane Cecília Kessler Nunes Deuschle Regis Augusto Norbert Deuschle Mariana Rocha Bortoluzzi Margareth Linde Athayde Physical chemistry evaluation of stability, spreadability, in vitro antioxidant, and photo-protective capacities of topical formulations containing Calendula officinalis L. leaf extract Brazilian Journal of Pharmaceutical Sciences Calendula officinalis L./farmacognosia Formulações tópicas/avaliação in vitro Calêndula/formulações tópicas/avaliação in vitro |
| title | Physical chemistry evaluation of stability, spreadability, in vitro antioxidant, and photo-protective capacities of topical formulations containing Calendula officinalis L. leaf extract |
| title_full | Physical chemistry evaluation of stability, spreadability, in vitro antioxidant, and photo-protective capacities of topical formulations containing Calendula officinalis L. leaf extract |
| title_fullStr | Physical chemistry evaluation of stability, spreadability, in vitro antioxidant, and photo-protective capacities of topical formulations containing Calendula officinalis L. leaf extract |
| title_full_unstemmed | Physical chemistry evaluation of stability, spreadability, in vitro antioxidant, and photo-protective capacities of topical formulations containing Calendula officinalis L. leaf extract |
| title_short | Physical chemistry evaluation of stability, spreadability, in vitro antioxidant, and photo-protective capacities of topical formulations containing Calendula officinalis L. leaf extract |
| title_sort | physical chemistry evaluation of stability spreadability in vitro antioxidant and photo protective capacities of topical formulations containing calendula officinalis l leaf extract |
| topic | Calendula officinalis L./farmacognosia Formulações tópicas/avaliação in vitro Calêndula/formulações tópicas/avaliação in vitro |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100063&lng=en&tlng=en |
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