Single-cell transcriptomics of neuroblastoma identifies chemoresistance-associated genes and pathways

Single-cell transcriptomics of neuroblastoma identifies chemoresistance-associated genes and pathways

High-Risk neuroblastoma (NB) survival rate is still <50%, despite treatments being more and more aggressive. The biggest hurdle liable to cancer therapy failure is the drug resistance by tumor cells that is likely due to the intra-tumor heterogeneity (ITH). To investigate the link between ITH and...

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Bibliographic Details
Main Authors: Marianna Avitabile, Ferdinando Bonfiglio, Vincenzo Aievola, Sueva Cantalupo, Teresa Maiorino, Vito Alessandro Lasorsa, Cinzia Domenicotti, Barbara Marengo, Heger Zbyněk, Adam Vojtěch, Achille Iolascon, Mario Capasso
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Drug resistance
Intra-tumor heterogenity (ITH)
Neuroblastoma (NB)
Prognostic biomarkers
Single cell transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003658

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