Effectiveness of Gout Therapy with Polyherbal Extract of Shallot (Allium ascalonicum L.) and Red Ginger (Zingiber officinale var rubrum) in Hyperuricemia Mice
Gout can cause inflammation of acute gout arthtritis, as well as other complications. Provision of chemical drugs in the long term have side effects. Shallots (Allium ascalonicum L.) contain flavonoids which can inhibit the xanthine oxidase enzyme, so as to reduce uric acid levels. Red ginger extrac...
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| Format: | Article |
| Language: | Indonesian |
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Universitas Gadjah Mada
2020-08-01
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| Series: | Jurnal Sain Veteriner |
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| Online Access: | https://journal.ugm.ac.id/jsv/article/view/51360 |
| _version_ | 1797822458386972672 |
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| author | Fathur Rohman Haryadi Dela Ria Nesti Ida Tjahajati Okti Herawati |
| author_facet | Fathur Rohman Haryadi Dela Ria Nesti Ida Tjahajati Okti Herawati |
| author_sort | Fathur Rohman Haryadi |
| collection | DOAJ |
| description | Gout can cause inflammation of acute gout arthtritis, as well as other complications. Provision of chemical drugs in the long term have side effects. Shallots (Allium ascalonicum L.) contain flavonoids which can inhibit the xanthine oxidase enzyme, so as to reduce uric acid levels. Red ginger extract (Zingiber officinale var rubrum) is rich in gingerol to reduce uric acid with anti-inflammatory effect. Polyberbal combination is expected to increase the effectiveness of therapy. The research aims to determine the effectiveness of polyherbal combinations. 25 male rats (2-3 months) were divided into five groups, namely negative control, positive control, (P1) 25% red ginger extract: 75% shallot, (P2) 50% red ginger extract: 50% shallot, ( P3) 75% red ginger extract: 25% shallot. Induction of potassium oxonate 250 mg / kg BW intraperitoneally on the 7th day. The first measurement of uric acid on the 14th day with Urid Acid Toos, the 15th to 28th days was administered herbal / chemical drugs according to the group. Measurement of second and third uric acid on days 21 and 28. Data were analyzed by one-way Anova (RAL), further significance tests using Least Significant Different (LSD). The results showed that administration of potassium oxonate and combination of herbal extracts had a significant effect (p <0.05) on uric acid levels in all groups. The most effective herbal combination doses are (P3) 75% red ginger (450 mg / 200 gr) and 25% shallot (150 mg / 200 gr BW). The conclusion of this study is the combination of red ginger extract and shallot can be recommended as a uric acid-lowering agent. |
| first_indexed | 2024-03-13T10:09:21Z |
| format | Article |
| id | doaj.art-37674cb44f484becb78e02814cfcd22c |
| institution | Directory Open Access Journal |
| issn | 2407-3733 |
| language | Indonesian |
| last_indexed | 2024-03-13T10:09:21Z |
| publishDate | 2020-08-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Jurnal Sain Veteriner |
| spelling | doaj.art-37674cb44f484becb78e02814cfcd22c2023-05-22T05:16:27ZindUniversitas Gadjah MadaJurnal Sain Veteriner2407-37332020-08-0138213514310.22146/jsv.5136029140Effectiveness of Gout Therapy with Polyherbal Extract of Shallot (Allium ascalonicum L.) and Red Ginger (Zingiber officinale var rubrum) in Hyperuricemia MiceFathur Rohman Haryadi0Dela Ria Nesti1Ida Tjahajati2Okti Herawati3Program Studi Diploma Kesehatan Hewan Departemen Teknologi Hayati dan Veteriner Sekolah Vokasi Universitas Gadjah MadaProgram Studi Diploma Kesehatan Hewan Departemen Teknologi Hayati dan Veteriner Sekolah Vokasi Universitas Gadjah MadaFakultas Kedokteran Hewan Universitas Gadjah MadaFakultas Kedokteran Hewan Universitas Gadjah MadaGout can cause inflammation of acute gout arthtritis, as well as other complications. Provision of chemical drugs in the long term have side effects. Shallots (Allium ascalonicum L.) contain flavonoids which can inhibit the xanthine oxidase enzyme, so as to reduce uric acid levels. Red ginger extract (Zingiber officinale var rubrum) is rich in gingerol to reduce uric acid with anti-inflammatory effect. Polyberbal combination is expected to increase the effectiveness of therapy. The research aims to determine the effectiveness of polyherbal combinations. 25 male rats (2-3 months) were divided into five groups, namely negative control, positive control, (P1) 25% red ginger extract: 75% shallot, (P2) 50% red ginger extract: 50% shallot, ( P3) 75% red ginger extract: 25% shallot. Induction of potassium oxonate 250 mg / kg BW intraperitoneally on the 7th day. The first measurement of uric acid on the 14th day with Urid Acid Toos, the 15th to 28th days was administered herbal / chemical drugs according to the group. Measurement of second and third uric acid on days 21 and 28. Data were analyzed by one-way Anova (RAL), further significance tests using Least Significant Different (LSD). The results showed that administration of potassium oxonate and combination of herbal extracts had a significant effect (p <0.05) on uric acid levels in all groups. The most effective herbal combination doses are (P3) 75% red ginger (450 mg / 200 gr) and 25% shallot (150 mg / 200 gr BW). The conclusion of this study is the combination of red ginger extract and shallot can be recommended as a uric acid-lowering agent.https://journal.ugm.ac.id/jsv/article/view/51360herbs |
| spellingShingle | Fathur Rohman Haryadi Dela Ria Nesti Ida Tjahajati Okti Herawati Effectiveness of Gout Therapy with Polyherbal Extract of Shallot (Allium ascalonicum L.) and Red Ginger (Zingiber officinale var rubrum) in Hyperuricemia Mice Jurnal Sain Veteriner herbs |
| title | Effectiveness of Gout Therapy with Polyherbal Extract of Shallot (Allium ascalonicum L.) and Red Ginger (Zingiber officinale var rubrum) in Hyperuricemia Mice |
| title_full | Effectiveness of Gout Therapy with Polyherbal Extract of Shallot (Allium ascalonicum L.) and Red Ginger (Zingiber officinale var rubrum) in Hyperuricemia Mice |
| title_fullStr | Effectiveness of Gout Therapy with Polyherbal Extract of Shallot (Allium ascalonicum L.) and Red Ginger (Zingiber officinale var rubrum) in Hyperuricemia Mice |
| title_full_unstemmed | Effectiveness of Gout Therapy with Polyherbal Extract of Shallot (Allium ascalonicum L.) and Red Ginger (Zingiber officinale var rubrum) in Hyperuricemia Mice |
| title_short | Effectiveness of Gout Therapy with Polyherbal Extract of Shallot (Allium ascalonicum L.) and Red Ginger (Zingiber officinale var rubrum) in Hyperuricemia Mice |
| title_sort | effectiveness of gout therapy with polyherbal extract of shallot allium ascalonicum l and red ginger zingiber officinale var rubrum in hyperuricemia mice |
| topic | herbs |
| url | https://journal.ugm.ac.id/jsv/article/view/51360 |
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