Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting

Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting

Abstract Background Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to discriminate between parasitic recurrence, either new infection or recrudescence. The current WHO guideline recommends...

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Bibliographic Details
Main Authors: Prabin Dahal, Kasia Stepniewska, Philippe J. Guerin, Umberto D’Alessandro, Ric N. Price, Julie A. Simpson
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Medical Research Methodology
Subjects:
Plasmodium falciparum
Efficacy
Indeterminate outcomes
Multiple imputation
Inverse probability weighting
Online Access:http://link.springer.com/article/10.1186/s12874-019-0856-z

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