Seroepidemiological Study of Toxoplasma gondii in Patients with Multiple Sclerosis in Ahvaz, Southeastern Iran
ABSTRACT Background and Objective: Toxoplasmosis is a common parasitic infection worldwide. The infection can be caused via consumption of contaminated meat and mother-to-child (congenital) transmission, causing changes in central nervous system tissue, eye irritation and sometimes death. The...
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| Format: | Article |
| Language: | English |
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Golestan University of Medical Sciences
2017-05-01
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| Series: | Medical Laboratory Journal |
| Subjects: | |
| Online Access: | http://mlj.goums.ac.ir/article-1-984-en.html |
| _version_ | 1818997435071987712 |
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| author | Mehdi Tavalla Marjan Sabzevari |
| author_facet | Mehdi Tavalla Marjan Sabzevari |
| author_sort | Mehdi Tavalla |
| collection | DOAJ |
| description | ABSTRACT
Background and Objective: Toxoplasmosis is a common parasitic infection worldwide. The infection can be caused via consumption of contaminated meat and mother-to-child (congenital) transmission, causing changes in central nervous system tissue, eye irritation and sometimes death. The human form of the disease is often asymptomatic and may be accompanied with general discomfort and swelling of the lymph nodes when associated with chorioretinitis. Acute infection in immunocompromised individuals could lead to mortality. The purpose of this study was to determine the prevalence of anti-Toxoplasma gondii antibodies in serum of patients with multiple sclerosis (MS) referred to the MS Center in city of Ahvaz, southeastern Iran.
Methods: Blood samples were taken from 100 patients with MS and 100 healthy control participants. After separating the serum, presence of anti-Toxoplasma antibodies (IgG, IgM) was evaluated by enzyme-linked immunosorbent assay.
Results: Frequency of anti-Toxoplasma IgG was 38% and 21% in the patients and controls, respectively. Toxoplasma IgM antibodies were not detected in any of the study groups. Pearson correlation coefficient showed a significant association between Toxoplasma antibodies and MS.
Conclusion: Due to high prevalence of toxoplasmosis in MS patients, it is recommended to measure serum titers of the patients regularly, and placed them under antiparasitic therapy when necessary.
Keywords: Toxoplasma, Multiple sclerosis, MS, Ahvaz. |
| first_indexed | 2024-12-20T21:45:35Z |
| format | Article |
| id | doaj.art-376bc2926a5b4e27a174b8cf9c245616 |
| institution | Directory Open Access Journal |
| issn | 2538-4449 |
| language | English |
| last_indexed | 2024-12-20T21:45:35Z |
| publishDate | 2017-05-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Medical Laboratory Journal |
| spelling | doaj.art-376bc2926a5b4e27a174b8cf9c2456162022-12-21T19:25:41ZengGolestan University of Medical SciencesMedical Laboratory Journal2538-44492017-05-0111369Seroepidemiological Study of Toxoplasma gondii in Patients with Multiple Sclerosis in Ahvaz, Southeastern IranMehdi Tavalla0Marjan Sabzevari1 Department of Medical Parasitology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Medical Parasitology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ABSTRACT Background and Objective: Toxoplasmosis is a common parasitic infection worldwide. The infection can be caused via consumption of contaminated meat and mother-to-child (congenital) transmission, causing changes in central nervous system tissue, eye irritation and sometimes death. The human form of the disease is often asymptomatic and may be accompanied with general discomfort and swelling of the lymph nodes when associated with chorioretinitis. Acute infection in immunocompromised individuals could lead to mortality. The purpose of this study was to determine the prevalence of anti-Toxoplasma gondii antibodies in serum of patients with multiple sclerosis (MS) referred to the MS Center in city of Ahvaz, southeastern Iran. Methods: Blood samples were taken from 100 patients with MS and 100 healthy control participants. After separating the serum, presence of anti-Toxoplasma antibodies (IgG, IgM) was evaluated by enzyme-linked immunosorbent assay. Results: Frequency of anti-Toxoplasma IgG was 38% and 21% in the patients and controls, respectively. Toxoplasma IgM antibodies were not detected in any of the study groups. Pearson correlation coefficient showed a significant association between Toxoplasma antibodies and MS. Conclusion: Due to high prevalence of toxoplasmosis in MS patients, it is recommended to measure serum titers of the patients regularly, and placed them under antiparasitic therapy when necessary. Keywords: Toxoplasma, Multiple sclerosis, MS, Ahvaz.http://mlj.goums.ac.ir/article-1-984-en.htmltoxoplasmamultiple sclerosismsahvaz. |
| spellingShingle | Mehdi Tavalla Marjan Sabzevari Seroepidemiological Study of Toxoplasma gondii in Patients with Multiple Sclerosis in Ahvaz, Southeastern Iran Medical Laboratory Journal toxoplasma multiple sclerosis ms ahvaz. |
| title | Seroepidemiological Study of Toxoplasma gondii in Patients with Multiple Sclerosis in Ahvaz, Southeastern Iran |
| title_full | Seroepidemiological Study of Toxoplasma gondii in Patients with Multiple Sclerosis in Ahvaz, Southeastern Iran |
| title_fullStr | Seroepidemiological Study of Toxoplasma gondii in Patients with Multiple Sclerosis in Ahvaz, Southeastern Iran |
| title_full_unstemmed | Seroepidemiological Study of Toxoplasma gondii in Patients with Multiple Sclerosis in Ahvaz, Southeastern Iran |
| title_short | Seroepidemiological Study of Toxoplasma gondii in Patients with Multiple Sclerosis in Ahvaz, Southeastern Iran |
| title_sort | seroepidemiological study of toxoplasma gondii in patients with multiple sclerosis in ahvaz southeastern iran |
| topic | toxoplasma multiple sclerosis ms ahvaz. |
| url | http://mlj.goums.ac.ir/article-1-984-en.html |
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