Restoring the neuroprotective capacity of glial cells under opioid addiction
Opioid addiction is a worldwide public health crisis stemming from the well-intentioned efforts of physicians to improve pain management in the 1990’s. The lack of knowledge behind the addictive tendencies of opioids, led to what is now known as the opioid epidemic causing significant social and eco...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Addiction Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772392522000220 |
| _version_ | 1811297996432736256 |
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| author | Alexis C. Spencer Bapurao Surnar Nagesh Kolishetti Michal Toborek Shanta Dhar |
| author_facet | Alexis C. Spencer Bapurao Surnar Nagesh Kolishetti Michal Toborek Shanta Dhar |
| author_sort | Alexis C. Spencer |
| collection | DOAJ |
| description | Opioid addiction is a worldwide public health crisis stemming from the well-intentioned efforts of physicians to improve pain management in the 1990’s. The lack of knowledge behind the addictive tendencies of opioids, led to what is now known as the opioid epidemic causing significant social and economic burdens across the globe. Research has been primarily focused on the behavioral components of addiction but has more recently been geared towards examining the role of neurons and glial cells in modulating addiction. Glial cells have been shown to modify the pharmacodynamics of opioids via proinflammatory reactivity, ultimately leading to excitotoxicity, disruption of neuro-homeostasis, and hypersensitivity to pain. It is hypothesized that restoring the neuroprotective capacity of glial cells via targeted therapeutics, will prevent further degeneration of neurons under chronic opioid abuse. Nanoparticle delivery systems are a valued tool in the fight against addiction due to their ability to carry diverse payloads, ability to permeate biological membranes, and ability for controlled release of the payload. This perspective offers insight into the cellular mechanisms underlying addiction, adjusting our focus to highlight the role of glial cells in modulating the efficacy of opioids and the effects of addiction. Moreover, we discuss different avenues in which nanotherapeutics can be optimized to target and increase the neuroprotectant capacity of glial cells to alleviate the burden of opioid toxicity in individuals suffering from chronic opioid addiction. |
| first_indexed | 2024-04-13T06:12:27Z |
| format | Article |
| id | doaj.art-376c231f660e43fa92890eae485b3205 |
| institution | Directory Open Access Journal |
| issn | 2772-3925 |
| language | English |
| last_indexed | 2024-04-13T06:12:27Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Addiction Neuroscience |
| spelling | doaj.art-376c231f660e43fa92890eae485b32052022-12-22T02:58:57ZengElsevierAddiction Neuroscience2772-39252022-12-014100027Restoring the neuroprotective capacity of glial cells under opioid addictionAlexis C. Spencer0Bapurao Surnar1Nagesh Kolishetti2Michal Toborek3Shanta Dhar4Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, United StatesDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, United StatesDepartment of Immunology and Nano-Medicine, Herbert Wertheim, College of Medicine, Florida International University, Miami, FL 33199, United States; Herbert Wertheim College of Medicine, Institute of Neuroimmune Pharmacology, Miami, FL 33199, United StatesDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, United StatesCorresponding author.; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, United States; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, United StatesOpioid addiction is a worldwide public health crisis stemming from the well-intentioned efforts of physicians to improve pain management in the 1990’s. The lack of knowledge behind the addictive tendencies of opioids, led to what is now known as the opioid epidemic causing significant social and economic burdens across the globe. Research has been primarily focused on the behavioral components of addiction but has more recently been geared towards examining the role of neurons and glial cells in modulating addiction. Glial cells have been shown to modify the pharmacodynamics of opioids via proinflammatory reactivity, ultimately leading to excitotoxicity, disruption of neuro-homeostasis, and hypersensitivity to pain. It is hypothesized that restoring the neuroprotective capacity of glial cells via targeted therapeutics, will prevent further degeneration of neurons under chronic opioid abuse. Nanoparticle delivery systems are a valued tool in the fight against addiction due to their ability to carry diverse payloads, ability to permeate biological membranes, and ability for controlled release of the payload. This perspective offers insight into the cellular mechanisms underlying addiction, adjusting our focus to highlight the role of glial cells in modulating the efficacy of opioids and the effects of addiction. Moreover, we discuss different avenues in which nanotherapeutics can be optimized to target and increase the neuroprotectant capacity of glial cells to alleviate the burden of opioid toxicity in individuals suffering from chronic opioid addiction.http://www.sciencedirect.com/science/article/pii/S2772392522000220NanomedicineOpioid crisisExcitotoxicityToll-like-receptor 4HyperalgesiaGlial cells |
| spellingShingle | Alexis C. Spencer Bapurao Surnar Nagesh Kolishetti Michal Toborek Shanta Dhar Restoring the neuroprotective capacity of glial cells under opioid addiction Addiction Neuroscience Nanomedicine Opioid crisis Excitotoxicity Toll-like-receptor 4 Hyperalgesia Glial cells |
| title | Restoring the neuroprotective capacity of glial cells under opioid addiction |
| title_full | Restoring the neuroprotective capacity of glial cells under opioid addiction |
| title_fullStr | Restoring the neuroprotective capacity of glial cells under opioid addiction |
| title_full_unstemmed | Restoring the neuroprotective capacity of glial cells under opioid addiction |
| title_short | Restoring the neuroprotective capacity of glial cells under opioid addiction |
| title_sort | restoring the neuroprotective capacity of glial cells under opioid addiction |
| topic | Nanomedicine Opioid crisis Excitotoxicity Toll-like-receptor 4 Hyperalgesia Glial cells |
| url | http://www.sciencedirect.com/science/article/pii/S2772392522000220 |
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