Current Alzheimer disease research highlights: evidence for novel risk factors
Abstract. Alzheimer disease (AD) is the most common type of dementia characterized by the progressive cognitive and social decline. Clinical drug targets have heavily focused on the amyloid hypothesis, with amyloid beta (Aβ), and tau proteins as key pathophysiologic markers of AD. However, no effect...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2021-09-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000001706 |
| _version_ | 1819135433405104128 |
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| author | Willa D. Brenowitz Yang Xiang Claire T. McEvoy Cui Yang Kristine Yaffe Wei-Dong Le Yue Leng Yuan-Yuan Ji |
| author_facet | Willa D. Brenowitz Yang Xiang Claire T. McEvoy Cui Yang Kristine Yaffe Wei-Dong Le Yue Leng Yuan-Yuan Ji |
| author_sort | Willa D. Brenowitz |
| collection | DOAJ |
| description | Abstract. Alzheimer disease (AD) is the most common type of dementia characterized by the progressive cognitive and social decline. Clinical drug targets have heavily focused on the amyloid hypothesis, with amyloid beta (Aβ), and tau proteins as key pathophysiologic markers of AD. However, no effective treatment has been developed so far, which prompts researchers to focus on other aspects of AD beyond Aβ, and tau proteins. Additionally, there is a mounting epidemiologic evidence that various environmental factors influence the development of dementia and that dementia etiology is likely heterogenous. In the past decades, new risk factors or potential etiologies have been widely studied. Here, we review several novel epidemiologic and clinical research developments that focus on sleep, hypoxia, diet, gut microbiota, and hearing impairment and their links to AD published in recent years. At the frontiers of AD research, these findings and updates could be worthy of further attention. |
| first_indexed | 2024-12-22T10:19:00Z |
| format | Article |
| id | doaj.art-376c46cda8294ba7a2f49e00a951d4e5 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-12-22T10:19:00Z |
| publishDate | 2021-09-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-376c46cda8294ba7a2f49e00a951d4e52022-12-21T18:29:40ZengWolters KluwerChinese Medical Journal0366-69992542-56412021-09-01134182150215910.1097/CM9.0000000000001706202109200-00003Current Alzheimer disease research highlights: evidence for novel risk factorsWilla D. BrenowitzYang XiangClaire T. McEvoyCui YangKristine YaffeWei-Dong LeYue LengYuan-Yuan JiAbstract. Alzheimer disease (AD) is the most common type of dementia characterized by the progressive cognitive and social decline. Clinical drug targets have heavily focused on the amyloid hypothesis, with amyloid beta (Aβ), and tau proteins as key pathophysiologic markers of AD. However, no effective treatment has been developed so far, which prompts researchers to focus on other aspects of AD beyond Aβ, and tau proteins. Additionally, there is a mounting epidemiologic evidence that various environmental factors influence the development of dementia and that dementia etiology is likely heterogenous. In the past decades, new risk factors or potential etiologies have been widely studied. Here, we review several novel epidemiologic and clinical research developments that focus on sleep, hypoxia, diet, gut microbiota, and hearing impairment and their links to AD published in recent years. At the frontiers of AD research, these findings and updates could be worthy of further attention.http://journals.lww.com/10.1097/CM9.0000000000001706 |
| spellingShingle | Willa D. Brenowitz Yang Xiang Claire T. McEvoy Cui Yang Kristine Yaffe Wei-Dong Le Yue Leng Yuan-Yuan Ji Current Alzheimer disease research highlights: evidence for novel risk factors Chinese Medical Journal |
| title | Current Alzheimer disease research highlights: evidence for novel risk factors |
| title_full | Current Alzheimer disease research highlights: evidence for novel risk factors |
| title_fullStr | Current Alzheimer disease research highlights: evidence for novel risk factors |
| title_full_unstemmed | Current Alzheimer disease research highlights: evidence for novel risk factors |
| title_short | Current Alzheimer disease research highlights: evidence for novel risk factors |
| title_sort | current alzheimer disease research highlights evidence for novel risk factors |
| url | http://journals.lww.com/10.1097/CM9.0000000000001706 |
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