Dendritic spinule-mediated structural synaptic plasticity: Implications for development, aging, and psychiatric disease

Dendritic spinule-mediated structural synaptic plasticity: Implications for development, aging, and psychiatric disease

Dendritic spines are highly dynamic and changes in their density, size, and shape underlie structural synaptic plasticity in cognition and memory. Fine membranous protrusions of spines, termed dendritic spinules, can contact neighboring neurons or glial cells and are positively regulated by neuronal...

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Bibliographic Details
Main Authors: Colleen R. Zaccard, Isabel Gippo, Amy Song, Changiz Geula, Peter Penzes
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
dendritic spines
memory and cognition
synaptic activity
synaptic connectivity
electron microscopy
enhanced resolution microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1059730/full

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