Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones
Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones exist exclusively in citrus genus, especially in the citrus peels which have been used as herbal medicine for several diseases for thousands of years. In this review, the natural occurrence, isolation and separation of PMFs; synthetic s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2009-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464608000042 |
| _version_ | 1819293927262388224 |
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| author | Shiming Li Min-Hsiung Pan Chih-Yu Lo Di Tan Yu Wang Fereidoon Shahidi Chi-Tang Ho |
| author_facet | Shiming Li Min-Hsiung Pan Chih-Yu Lo Di Tan Yu Wang Fereidoon Shahidi Chi-Tang Ho |
| author_sort | Shiming Li |
| collection | DOAJ |
| description | Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones exist exclusively in citrus genus, especially in the citrus peels which have been used as herbal medicine for several diseases for thousands of years. In this review, the natural occurrence, isolation and separation of PMFs; synthetic scheme of hydroxylated PMF preparation, especially the reaction mechanism of preparation of 5-hydroxylated PMFs; biotransformation and metabolic fate of PMFs; the preliminary study on PMF bioavailability and the close relationship among solubility, permeability, absorption and oral bioavailability are summarized. The published bioactivity data on anti-inflammatory, anti-cancer and anti-atherogenic properties of PMFs have also been detailed along with a report of new findings of hydroxylated PMFs and their potent biological activities. |
| first_indexed | 2024-12-24T04:18:12Z |
| format | Article |
| id | doaj.art-376cccdb71ec4c13ac8a6b03da4e26f3 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T04:18:12Z |
| publishDate | 2009-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-376cccdb71ec4c13ac8a6b03da4e26f32022-12-21T17:15:53ZengElsevierJournal of Functional Foods1756-46462009-01-0111212Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavonesShiming Li0Min-Hsiung Pan1Chih-Yu Lo2Di Tan3Yu Wang4Fereidoon Shahidi5Chi-Tang Ho6Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USADepartment of Seafood Science, National Kaohsiung Marine University, Kaohsiung 811, TaiwanDepartment of Food Science, National Chiayi University, No. 300 Syuefu Road, Chiayi 600, TaiwanDepartment of Food Science, Rutgers University, New Brunswick, NJ 08901, USADepartment of Food Science, Rutgers University, New Brunswick, NJ 08901, USADepartment of Biochemistry, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3X9Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA; Graduate Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan; Corresponding author: Address: Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA. Tel.: +1 732 932 9611x235; fax: +1 732 932 6776.Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones exist exclusively in citrus genus, especially in the citrus peels which have been used as herbal medicine for several diseases for thousands of years. In this review, the natural occurrence, isolation and separation of PMFs; synthetic scheme of hydroxylated PMF preparation, especially the reaction mechanism of preparation of 5-hydroxylated PMFs; biotransformation and metabolic fate of PMFs; the preliminary study on PMF bioavailability and the close relationship among solubility, permeability, absorption and oral bioavailability are summarized. The published bioactivity data on anti-inflammatory, anti-cancer and anti-atherogenic properties of PMFs have also been detailed along with a report of new findings of hydroxylated PMFs and their potent biological activities.http://www.sciencedirect.com/science/article/pii/S1756464608000042PolymethoxyflavonesHydroxylated polymethoxyflavonesAnti-inflammatoryAnti-cancerAnti-atherogenic propertiesBioavailability |
| spellingShingle | Shiming Li Min-Hsiung Pan Chih-Yu Lo Di Tan Yu Wang Fereidoon Shahidi Chi-Tang Ho Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones Journal of Functional Foods Polymethoxyflavones Hydroxylated polymethoxyflavones Anti-inflammatory Anti-cancer Anti-atherogenic properties Bioavailability |
| title | Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones |
| title_full | Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones |
| title_fullStr | Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones |
| title_full_unstemmed | Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones |
| title_short | Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones |
| title_sort | chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones |
| topic | Polymethoxyflavones Hydroxylated polymethoxyflavones Anti-inflammatory Anti-cancer Anti-atherogenic properties Bioavailability |
| url | http://www.sciencedirect.com/science/article/pii/S1756464608000042 |
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