Biopharmaceutical Development of a Bifonazole Multiple Emulsion for Enhanced Epidermal Delivery

Biopharmaceutical Development of a Bifonazole Multiple Emulsion for Enhanced Epidermal Delivery

Efficient topical delivery of imidazolic antifungals faces the challenge of overcoming its limited water solubility and its required long-lasting duration of treatments. In this paper, a hydrophilic multiple emulsion (ME) of Bifonazole (BFZ) is shown to maximize its skin retention, minimize its skin...

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Bibliographic Details
Main Authors: Joaquim Suñer-Carbó, Ana Calpena-Campmany, Lyda Halbaut-Bellowa, Beatriz Clares-Naveros, María José Rodriguez-Lagunas, Elena Barbolini, Joanna Zamarbide-Losada, Antonio Boix-Montañés
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Pharmaceutics
Subjects:
multiple emulsion
bifonazole
pseudoplastic
drug release
skin penetration
skin permeation
skin integrity
TEWL
epidermal histology
Online Access:https://www.mdpi.com/1999-4923/11/2/66

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