Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome
Background and Aim: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease. Recent studies showed endothelial dysfunction and pentraxin-3 both of an early marker for development of cardiovascular disease. The aim of the study was to evaluate the relationship...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Annals of Thoracic Medicine |
| Subjects: | |
| Online Access: | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2015;volume=10;issue=3;spage=199;epage=203;aulast=Kanbay |
| _version_ | 1811270964356317184 |
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| author | Asiye Kanbay Elif Kaya Hakan Büyükoglan Mehmet Güngör Kaya Zuhal Özer Simsek Nuri Tutar Ramazan Demir |
| author_facet | Asiye Kanbay Elif Kaya Hakan Büyükoglan Mehmet Güngör Kaya Zuhal Özer Simsek Nuri Tutar Ramazan Demir |
| author_sort | Asiye Kanbay |
| collection | DOAJ |
| description | Background and Aim: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease. Recent studies showed endothelial dysfunction and pentraxin-3 both of an early marker for development of cardiovascular disease. The aim of the study was to evaluate the relationship between severity of OSAS and endothelial dysfunction and inflammatory markers including pentraxin-3 and high-sensitivity C-reactive protein (hs-CRP).
Methods: This was a cross-sectional study in which patients who had undergone a polysomnographic study for diagnosis of OSAS were recruited. Included patients were grouped according to apnea-hypopnea index (AHI) as mild (AHI between 5 and 14.9) and moderate-severe OSAS (AHI 15). Patients with AHI < 5 served as control group. Endothelial function was evaluated by flow-mediated dilatation (FMD). Serum pentraxin-3 and hs-CRP levels were measured.
Results: Eighty-three patients enrolled for the study. We found a significant increment in pentraxin-3 and hs-CRP levels and a significant decrement in FMD as the severity of OSAS increased. There was a negative correlation between FMD and AHI, pentraxin, and hs-CRP.
Conclusion: OSAS patients have significantly elevated pentraxin-3 levels and endothelial dysfunction. Furthermore, both pentraxin-3 and endothelial dysfunction were independently associated with severity of OSAS defined by AHI. |
| first_indexed | 2024-04-12T22:11:40Z |
| format | Article |
| id | doaj.art-377173357fdd44ad9cb1bb19509332bc |
| institution | Directory Open Access Journal |
| issn | 1817-1737 1998-3557 |
| language | English |
| last_indexed | 2024-04-12T22:11:40Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Thoracic Medicine |
| spelling | doaj.art-377173357fdd44ad9cb1bb19509332bc2022-12-22T03:14:42ZengWolters Kluwer Medknow PublicationsAnnals of Thoracic Medicine1817-17371998-35572015-01-0110319920310.4103/1817-1737.160840Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndromeAsiye KanbayElif KayaHakan BüyükoglanMehmet Güngör KayaZuhal Özer SimsekNuri TutarRamazan DemirBackground and Aim: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease. Recent studies showed endothelial dysfunction and pentraxin-3 both of an early marker for development of cardiovascular disease. The aim of the study was to evaluate the relationship between severity of OSAS and endothelial dysfunction and inflammatory markers including pentraxin-3 and high-sensitivity C-reactive protein (hs-CRP). Methods: This was a cross-sectional study in which patients who had undergone a polysomnographic study for diagnosis of OSAS were recruited. Included patients were grouped according to apnea-hypopnea index (AHI) as mild (AHI between 5 and 14.9) and moderate-severe OSAS (AHI 15). Patients with AHI < 5 served as control group. Endothelial function was evaluated by flow-mediated dilatation (FMD). Serum pentraxin-3 and hs-CRP levels were measured. Results: Eighty-three patients enrolled for the study. We found a significant increment in pentraxin-3 and hs-CRP levels and a significant decrement in FMD as the severity of OSAS increased. There was a negative correlation between FMD and AHI, pentraxin, and hs-CRP. Conclusion: OSAS patients have significantly elevated pentraxin-3 levels and endothelial dysfunction. Furthermore, both pentraxin-3 and endothelial dysfunction were independently associated with severity of OSAS defined by AHI.http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2015;volume=10;issue=3;spage=199;epage=203;aulast=KanbayEndothelial dysfunctionflow-mediated dilatationhs-CRPobstructive sleep apneapentraxin-3 |
| spellingShingle | Asiye Kanbay Elif Kaya Hakan Büyükoglan Mehmet Güngör Kaya Zuhal Özer Simsek Nuri Tutar Ramazan Demir Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome Annals of Thoracic Medicine Endothelial dysfunction flow-mediated dilatation hs-CRP obstructive sleep apnea pentraxin-3 |
| title | Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome |
| title_full | Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome |
| title_fullStr | Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome |
| title_full_unstemmed | Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome |
| title_short | Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome |
| title_sort | correlation between pentraxin 3 and endothelial dysfunction in obstructive sleep apnea syndrome |
| topic | Endothelial dysfunction flow-mediated dilatation hs-CRP obstructive sleep apnea pentraxin-3 |
| url | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2015;volume=10;issue=3;spage=199;epage=203;aulast=Kanbay |
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