Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis
Abstract Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders. Objective: This meta-analysis was conduct...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2023-05-01
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| Series: | International Journal of Reproductive BioMedicine |
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| Online Access: | https://doi.org/10.18502/ijrm.v21i5.13470 |
| _version_ | 1797799204881432576 |
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| author | Seyed Sobhan Bahreiny Elnaz Harooni Mohammad Reza Dabbagh Reza Ebrahimi |
| author_facet | Seyed Sobhan Bahreiny Elnaz Harooni Mohammad Reza Dabbagh Reza Ebrahimi |
| author_sort | Seyed Sobhan Bahreiny |
| collection | DOAJ |
| description | Abstract Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders. Objective: This meta-analysis was conducted to determine the relationship between circulating preptin levels and PCOS. Materials and Methods: A systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and the Google Scholar search engine, using a predefined search strategy. A random-effects model was used to combine standard mean difference (SMD) and 95% CI to compare results between groups. Meta-regression and subgroup analysis were also performed to reveal the sources of heterogeneity. Results: The meta-analysis encompassed a total of 8 studies and 582 participants. The results indicate a statistically significant association between PCOS and serum preptin levels, with a pooled standardized mean difference (SMD = 1.35; 95% CI]: 0.63-2.08; p < 0.001). Further analysis suggested a significant difference in serum preptin levels between women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 2.40; 95% CI: 1.17-3.63; p < 0.001) within the subgroup. Conclusion: Our meta-analysis shows that increased serum preptin levels are associated with PCOS, suggesting that preptin may be related to the pathogenesis of PCOS and may be recognized as a novel diagnostic biomarker for PCOS. However, further studies are needed to confirm our results. |
| first_indexed | 2024-03-13T04:15:24Z |
| format | Article |
| id | doaj.art-37722ddf231d4f9bbeb01bdda19a388f |
| institution | Directory Open Access Journal |
| issn | 2476-4108 2476-3772 |
| language | English |
| last_indexed | 2024-03-13T04:15:24Z |
| publishDate | 2023-05-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj.art-37722ddf231d4f9bbeb01bdda19a388f2023-06-21T05:03:05ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722023-05-01210536737810.18502/ijrm.v21i5.13470ijrm.v21i5.13470Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysisSeyed Sobhan Bahreiny0Elnaz Harooni1Mohammad Reza Dabbagh2Reza Ebrahimi3 Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Department of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, Iran.Abstract Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders. Objective: This meta-analysis was conducted to determine the relationship between circulating preptin levels and PCOS. Materials and Methods: A systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and the Google Scholar search engine, using a predefined search strategy. A random-effects model was used to combine standard mean difference (SMD) and 95% CI to compare results between groups. Meta-regression and subgroup analysis were also performed to reveal the sources of heterogeneity. Results: The meta-analysis encompassed a total of 8 studies and 582 participants. The results indicate a statistically significant association between PCOS and serum preptin levels, with a pooled standardized mean difference (SMD = 1.35; 95% CI]: 0.63-2.08; p < 0.001). Further analysis suggested a significant difference in serum preptin levels between women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 2.40; 95% CI: 1.17-3.63; p < 0.001) within the subgroup. Conclusion: Our meta-analysis shows that increased serum preptin levels are associated with PCOS, suggesting that preptin may be related to the pathogenesis of PCOS and may be recognized as a novel diagnostic biomarker for PCOS. However, further studies are needed to confirm our results.https://doi.org/10.18502/ijrm.v21i5.13470polycystic ovary syndrome, proinsulin-like growth factor ii, preptin, meta-analysis. |
| spellingShingle | Seyed Sobhan Bahreiny Elnaz Harooni Mohammad Reza Dabbagh Reza Ebrahimi Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis International Journal of Reproductive BioMedicine polycystic ovary syndrome, proinsulin-like growth factor ii, preptin, meta-analysis. |
| title | Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis |
| title_full | Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis |
| title_fullStr | Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis |
| title_full_unstemmed | Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis |
| title_short | Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis |
| title_sort | circulating serum preptin levels in women with polycystic ovary syndrome a systematic review and meta analysis |
| topic | polycystic ovary syndrome, proinsulin-like growth factor ii, preptin, meta-analysis. |
| url | https://doi.org/10.18502/ijrm.v21i5.13470 |
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