Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years
Abstract Background Nutritional intervention preconception and throughout pregnancy has been proposed as an approach to promoting healthy postnatal weight gain in the offspring but few randomised trials have examined this. Methods Measurements of weight and length were obtained at multiple time poin...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Medicine |
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| Online Access: | https://doi.org/10.1186/s12916-024-03246-w |
| _version_ | 1797274356522418176 |
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| author | Jaz Lyons-Reid José G. B. Derraik Timothy Kenealy Benjamin B. Albert J. Manuel Ramos Nieves Cathriona R. Monnard Phil Titcombe Heidi Nield Sheila J. Barton Sarah El-Heis Elizabeth Tham Keith M. Godfrey Shiao-Yng Chan Wayne S. Cutfield NiPPeR Study Group |
| author_facet | Jaz Lyons-Reid José G. B. Derraik Timothy Kenealy Benjamin B. Albert J. Manuel Ramos Nieves Cathriona R. Monnard Phil Titcombe Heidi Nield Sheila J. Barton Sarah El-Heis Elizabeth Tham Keith M. Godfrey Shiao-Yng Chan Wayne S. Cutfield NiPPeR Study Group |
| author_sort | Jaz Lyons-Reid |
| collection | DOAJ |
| description | Abstract Background Nutritional intervention preconception and throughout pregnancy has been proposed as an approach to promoting healthy postnatal weight gain in the offspring but few randomised trials have examined this. Methods Measurements of weight and length were obtained at multiple time points from birth to 2 years among 576 offspring of women randomised to receive preconception and antenatally either a supplement containing myo-inositol, probiotics, and additional micronutrients (intervention) or a standard micronutrient supplement (control). We examined the influence on age- and sex-standardised BMI at 2 years (WHO standards, adjusting for study site, sex, maternal parity, smoking and pre-pregnancy BMI, and gestational age), together with the change in weight, length, BMI from birth, and weight gain trajectories using latent class growth analysis. Results At 2 years, there was a trend towards lower mean BMI among intervention offspring (adjusted mean difference [aMD] − 0.14 SD [95% CI 0.30, 0.02], p = 0.09), and fewer had a BMI > 95th percentile (i.e. > 1.65 SD, 9.2% vs 18.0%, adjusted risk ratio [aRR] 0.51 [95% CI 0.31, 0.82], p = 0.006). Longitudinal data revealed that intervention offspring had a 24% reduced risk of experiencing rapid weight gain > 0.67 SD in the first year of life (21.9% vs 31.1%, aRR 0.76 [95% CI 0.58, 1.00], p = 0.047). The risk was likewise decreased for sustained weight gain > 1.34 SD in the first 2 years of life (7.7% vs 17.1%, aRR 0.55 [95% CI 0.34, 0.88], p = 0.014). From five weight gain trajectories identified, there were more intervention offspring in the “normal” weight gain trajectory characterised by stable weight SDS around 0 SD from birth to 2 years (38.8% vs 30.1%, RR 1.29 [95% CI 1.03, 1.62], p = 0.029). Conclusions Supplementation with myo-inositol, probiotics, and additional micronutrients preconception and in pregnancy reduced the incidence of rapid weight gain and obesity at 2 years among offspring. Previous reports suggest these effects will likely translate to health benefits, but longer-term follow-up is needed to evaluate this. Trial registration ClinicalTrials.gov, NCT02509988 (Universal Trial Number U1111-1171–8056). Registered on 16 July 2015. |
| first_indexed | 2024-03-07T14:57:17Z |
| format | Article |
| id | doaj.art-377284320c8d4aaa8e14a5fc490d4c73 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-03-07T14:57:17Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-377284320c8d4aaa8e14a5fc490d4c732024-03-05T19:21:29ZengBMCBMC Medicine1741-70152024-01-0122111310.1186/s12916-024-03246-wImpact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 yearsJaz Lyons-Reid0José G. B. Derraik1Timothy Kenealy2Benjamin B. Albert3J. Manuel Ramos Nieves4Cathriona R. Monnard5Phil Titcombe6Heidi Nield7Sheila J. Barton8Sarah El-Heis9Elizabeth Tham10Keith M. Godfrey11Shiao-Yng Chan12Wayne S. Cutfield13NiPPeR Study GroupLiggins Institute, The University of AucklandLiggins Institute, The University of AucklandLiggins Institute, The University of AucklandLiggins Institute, The University of AucklandNestlé Institute of Health Sciences, Nestlé Research, Société Des Produits Nestlé S.ANestlé Institute of Health Sciences, Nestlé Research, Société Des Produits Nestlé S.AMRC Lifecourse Epidemiology Centre, University of SouthamptonMRC Lifecourse Epidemiology Centre, University of SouthamptonMRC Lifecourse Epidemiology Centre, University of SouthamptonMRC Lifecourse Epidemiology Centre, University of SouthamptonSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR)MRC Lifecourse Epidemiology Centre, University of SouthamptonSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR)Liggins Institute, The University of AucklandAbstract Background Nutritional intervention preconception and throughout pregnancy has been proposed as an approach to promoting healthy postnatal weight gain in the offspring but few randomised trials have examined this. Methods Measurements of weight and length were obtained at multiple time points from birth to 2 years among 576 offspring of women randomised to receive preconception and antenatally either a supplement containing myo-inositol, probiotics, and additional micronutrients (intervention) or a standard micronutrient supplement (control). We examined the influence on age- and sex-standardised BMI at 2 years (WHO standards, adjusting for study site, sex, maternal parity, smoking and pre-pregnancy BMI, and gestational age), together with the change in weight, length, BMI from birth, and weight gain trajectories using latent class growth analysis. Results At 2 years, there was a trend towards lower mean BMI among intervention offspring (adjusted mean difference [aMD] − 0.14 SD [95% CI 0.30, 0.02], p = 0.09), and fewer had a BMI > 95th percentile (i.e. > 1.65 SD, 9.2% vs 18.0%, adjusted risk ratio [aRR] 0.51 [95% CI 0.31, 0.82], p = 0.006). Longitudinal data revealed that intervention offspring had a 24% reduced risk of experiencing rapid weight gain > 0.67 SD in the first year of life (21.9% vs 31.1%, aRR 0.76 [95% CI 0.58, 1.00], p = 0.047). The risk was likewise decreased for sustained weight gain > 1.34 SD in the first 2 years of life (7.7% vs 17.1%, aRR 0.55 [95% CI 0.34, 0.88], p = 0.014). From five weight gain trajectories identified, there were more intervention offspring in the “normal” weight gain trajectory characterised by stable weight SDS around 0 SD from birth to 2 years (38.8% vs 30.1%, RR 1.29 [95% CI 1.03, 1.62], p = 0.029). Conclusions Supplementation with myo-inositol, probiotics, and additional micronutrients preconception and in pregnancy reduced the incidence of rapid weight gain and obesity at 2 years among offspring. Previous reports suggest these effects will likely translate to health benefits, but longer-term follow-up is needed to evaluate this. Trial registration ClinicalTrials.gov, NCT02509988 (Universal Trial Number U1111-1171–8056). Registered on 16 July 2015.https://doi.org/10.1186/s12916-024-03246-wNutritional supplementationInfant weight gainPreconceptionPregnancyRandomised trial |
| spellingShingle | Jaz Lyons-Reid José G. B. Derraik Timothy Kenealy Benjamin B. Albert J. Manuel Ramos Nieves Cathriona R. Monnard Phil Titcombe Heidi Nield Sheila J. Barton Sarah El-Heis Elizabeth Tham Keith M. Godfrey Shiao-Yng Chan Wayne S. Cutfield NiPPeR Study Group Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years BMC Medicine Nutritional supplementation Infant weight gain Preconception Pregnancy Randomised trial |
| title | Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years |
| title_full | Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years |
| title_fullStr | Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years |
| title_full_unstemmed | Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years |
| title_short | Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years |
| title_sort | impact of preconception and antenatal supplementation with myo inositol probiotics and micronutrients on offspring bmi and weight gain over the first 2 years |
| topic | Nutritional supplementation Infant weight gain Preconception Pregnancy Randomised trial |
| url | https://doi.org/10.1186/s12916-024-03246-w |
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