Mid-titer human convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection in rhesus macaques

Mid-titer human convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection in rhesus macaques

IntroductionSARS-CoV-2 is a respiratory pathogen currently causing a worldwide pandemic, with resulting pathology of differing severity in humans, from mild illness to severe disease and death. The rhesus macaque model of COVID-19 was utilized to evaluate the added benefit of prophylactic administra...

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Bibliographic Details
Main Authors: Brandon J. Beddingfield, Nicholas J. Maness, Skye Spencer, Jay Rappaport, Pyone Pyone Aye, Kasi Russell-Lodrigue, Lara A. Doyle-Meyers, Robert V. Blair, HongMei Gao, David Montefiori, Chad J. Roy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
COVID-19
rhesus macaque
convalescent plasma
prophylaxis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1085883/full

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