A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer
Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exert a role of engrams for making the condition of specific inflammation in the gut. Dysregulation of imm...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2022-10-01
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| Series: | Exploration of Medicine |
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| Online Access: | https://www.explorationpub.com/Journals/em/Article/1001108 |
| _version_ | 1811326076593373184 |
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| author | Yuka Ikeda Kurumi Taniguchi Sayuri Yoshikawa Haruka Sawamura Ai Tsuji Satoru Matsuda |
| author_facet | Yuka Ikeda Kurumi Taniguchi Sayuri Yoshikawa Haruka Sawamura Ai Tsuji Satoru Matsuda |
| author_sort | Yuka Ikeda |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exert a role of engrams for making the condition of specific inflammation in the gut. Dysregulation of immune cells induced by the command of engrams might be crucial in the pathogenesis of damages in gut epithelium. The anti-proliferative (APRO) family of anti-proliferative proteins characterized by immediate early responsive gene-products that might be involved in the machinery of the carcinogenesis in IBD. Herein, it is suggested that some probiotics with specific bacteria could prevent the development and/or progression of the IBD related tumors. In addition, consideration regarding the application of studying APRO family proteins for the comprehension of IBD related tumors has been presented. It is hypothesized that overexpression of Tob1, a member of APRO family proteins, in the epithelium of IBD could suppress the function of adjacent cytotoxic immune cells possibly via the paracrine signaling. |
| first_indexed | 2024-04-13T14:44:10Z |
| format | Article |
| id | doaj.art-3777ebf49a7b4daab5425f7f27ad281d |
| institution | Directory Open Access Journal |
| issn | 2692-3106 |
| language | English |
| last_indexed | 2024-04-13T14:44:10Z |
| publishDate | 2022-10-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj.art-3777ebf49a7b4daab5425f7f27ad281d2022-12-22T02:42:49ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062022-10-013546847810.37349/emed.2022.00108A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancerYuka Ikeda0https://orcid.org/0000-0003-4805-1758Kurumi Taniguchi1https://orcid.org/0000-0003-3940-1787Sayuri Yoshikawa2https://orcid.org/0000-0002-1803-2620Haruka Sawamura3https://orcid.org/0000-0001-9556-6602Ai Tsuji4https://orcid.org/0000-0003-1619-7592Satoru Matsuda5https://orcid.org/0000-0003-4274-5345Department of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanInflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exert a role of engrams for making the condition of specific inflammation in the gut. Dysregulation of immune cells induced by the command of engrams might be crucial in the pathogenesis of damages in gut epithelium. The anti-proliferative (APRO) family of anti-proliferative proteins characterized by immediate early responsive gene-products that might be involved in the machinery of the carcinogenesis in IBD. Herein, it is suggested that some probiotics with specific bacteria could prevent the development and/or progression of the IBD related tumors. In addition, consideration regarding the application of studying APRO family proteins for the comprehension of IBD related tumors has been presented. It is hypothesized that overexpression of Tob1, a member of APRO family proteins, in the epithelium of IBD could suppress the function of adjacent cytotoxic immune cells possibly via the paracrine signaling.https://www.explorationpub.com/Journals/em/Article/1001108anti-proliferative family proteinstob1carcinogenesisinflammatory bowel diseaseulcerative colitiscrohn’s disease |
| spellingShingle | Yuka Ikeda Kurumi Taniguchi Sayuri Yoshikawa Haruka Sawamura Ai Tsuji Satoru Matsuda A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer Exploration of Medicine anti-proliferative family proteins tob1 carcinogenesis inflammatory bowel disease ulcerative colitis crohn’s disease |
| title | A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer |
| title_full | A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer |
| title_fullStr | A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer |
| title_full_unstemmed | A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer |
| title_short | A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer |
| title_sort | budding concept with certain microbiota anti proliferative family proteins and engram theory for the innovative treatment of colon cancer |
| topic | anti-proliferative family proteins tob1 carcinogenesis inflammatory bowel disease ulcerative colitis crohn’s disease |
| url | https://www.explorationpub.com/Journals/em/Article/1001108 |
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