Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

In diabetic patients, dyslipidemia frequently contributes to organ damage such as diabetic kidney disease (DKD). Dyslipidemia is associated with both excessive deposition of triacylglycerol (TAG) in lipid droplets (LDs) and lipotoxicity. Yet, it is unclear how these two effects correlate with each o...

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Bibliographic Details
Main Authors: Albert Pérez-Martí, Suresh Ramakrishnan, Jiayi Li, Aurelien Dugourd, Martijn R Molenaar, Luigi R De La Motte, Kelli Grand, Anis Mansouri, Mélanie Parisot, Soeren S Lienkamp, Julio Saez-Rodriguez, Matias Simons
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
diabetic nephropathy
proximal tubules
lipotoxicity
ER stress
membrane order
lipid bilayer stress
Online Access:https://elifesciences.org/articles/74391

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