Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review
Adamantinoma-like Ewing sarcoma (ALES) of the salivary glands is an exceedingly rare malignancy defined by the t(11,22) EWSR1::FLI1 fusion, with complex epithelial differentiation. To identify features that can allow for better recognition of this disease entity, we reviewed all published reports of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-04-01
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| Series: | Therapeutic Advances in Medical Oncology |
| Online Access: | https://doi.org/10.1177/17588359231165979 |
| _version_ | 1797844708484972544 |
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| author | Eleonora Lauricella Anna Manicone Federica Cavallo Gian Paolo Dagrada Giovanni Centonze Rossella Bertulli Pasquale Quattrone Camillo Porta Mauro Cives |
| author_facet | Eleonora Lauricella Anna Manicone Federica Cavallo Gian Paolo Dagrada Giovanni Centonze Rossella Bertulli Pasquale Quattrone Camillo Porta Mauro Cives |
| author_sort | Eleonora Lauricella |
| collection | DOAJ |
| description | Adamantinoma-like Ewing sarcoma (ALES) of the salivary glands is an exceedingly rare malignancy defined by the t(11,22) EWSR1::FLI1 fusion, with complex epithelial differentiation. To identify features that can allow for better recognition of this disease entity, we reviewed all published reports of molecularly confirmed ALES of the salivary glands and explored epidemiological, clinical, radiological, pathological, and therapeutic characteristics of a population of 21 patients including a single newly reported patient from our group. We searched the English-language literature indexed in PubMed, Medline, Scopus, and Web of Science using the keyword ‘Adamantinoma-like Ewing sarcoma’ published up to June 2022. The median age at diagnosis was 46 years, and a slight female sex predilection was observed. Most tumors originated in the parotid gland (86%) and presented as a painless palpable mass with a median diameter of 3.6 cm. Metastatic dissemination was reported only in one patient (5%), and after a median follow-up of 13 months the 1-year overall survival rate was 92%. Salivary gland ALES were frequently misdiagnosed at presentation (62% of cases) and were pathologically characterized by the presence of highly monomorphic small round blue cells with infiltrative pattern and positive immunostaining for CD99 and high- and low-molecular weight cytokeratins. Epidemiological and clinical features of salivary gland ALES raise questions on the incorporation of this malignancy in the Ewing sarcoma family tumor group. |
| first_indexed | 2024-04-09T17:26:53Z |
| format | Article |
| id | doaj.art-377eb8c2bdc84c8fa69194e2bc87126f |
| institution | Directory Open Access Journal |
| issn | 1758-8359 |
| language | English |
| last_indexed | 2024-04-09T17:26:53Z |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Medical Oncology |
| spelling | doaj.art-377eb8c2bdc84c8fa69194e2bc87126f2023-04-18T11:04:51ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83592023-04-011510.1177/17588359231165979Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature reviewEleonora LauricellaAnna ManiconeFederica CavalloGian Paolo DagradaGiovanni CentonzeRossella BertulliPasquale QuattroneCamillo PortaMauro CivesAdamantinoma-like Ewing sarcoma (ALES) of the salivary glands is an exceedingly rare malignancy defined by the t(11,22) EWSR1::FLI1 fusion, with complex epithelial differentiation. To identify features that can allow for better recognition of this disease entity, we reviewed all published reports of molecularly confirmed ALES of the salivary glands and explored epidemiological, clinical, radiological, pathological, and therapeutic characteristics of a population of 21 patients including a single newly reported patient from our group. We searched the English-language literature indexed in PubMed, Medline, Scopus, and Web of Science using the keyword ‘Adamantinoma-like Ewing sarcoma’ published up to June 2022. The median age at diagnosis was 46 years, and a slight female sex predilection was observed. Most tumors originated in the parotid gland (86%) and presented as a painless palpable mass with a median diameter of 3.6 cm. Metastatic dissemination was reported only in one patient (5%), and after a median follow-up of 13 months the 1-year overall survival rate was 92%. Salivary gland ALES were frequently misdiagnosed at presentation (62% of cases) and were pathologically characterized by the presence of highly monomorphic small round blue cells with infiltrative pattern and positive immunostaining for CD99 and high- and low-molecular weight cytokeratins. Epidemiological and clinical features of salivary gland ALES raise questions on the incorporation of this malignancy in the Ewing sarcoma family tumor group.https://doi.org/10.1177/17588359231165979 |
| spellingShingle | Eleonora Lauricella Anna Manicone Federica Cavallo Gian Paolo Dagrada Giovanni Centonze Rossella Bertulli Pasquale Quattrone Camillo Porta Mauro Cives Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review Therapeutic Advances in Medical Oncology |
| title | Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review |
| title_full | Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review |
| title_fullStr | Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review |
| title_full_unstemmed | Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review |
| title_short | Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review |
| title_sort | adamantinoma like ewing sarcoma of the salivary glands a case report and systematic literature review |
| url | https://doi.org/10.1177/17588359231165979 |
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