Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis
Over the past few decades, several publications have investigated the role of Epstein-Barr virus (EBV) in head and neck squamous cell carcinomas, and an increasing number of them have shown its presence in laryngeal tumors. The purpose of this meta-analysis was to evaluate the association of EBV wit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/11/1429 |
| _version_ | 1797508854577102848 |
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| author | Marcos Antonio Pereira de Lima Álife Diêgo Lima Silva Antônio Carlos Silva do Nascimento Filho Thiago Lima Cordeiro João Pedro de Souza Bezerra Maria Aline Barroso Rocha Sally de França Lacerda Pinheiro Roberto Flávio Fontenelle Pinheiro Junior Maria do Socorro Vieira Gadelha Cláudio Gleidiston Lima da Silva |
| author_facet | Marcos Antonio Pereira de Lima Álife Diêgo Lima Silva Antônio Carlos Silva do Nascimento Filho Thiago Lima Cordeiro João Pedro de Souza Bezerra Maria Aline Barroso Rocha Sally de França Lacerda Pinheiro Roberto Flávio Fontenelle Pinheiro Junior Maria do Socorro Vieira Gadelha Cláudio Gleidiston Lima da Silva |
| author_sort | Marcos Antonio Pereira de Lima |
| collection | DOAJ |
| description | Over the past few decades, several publications have investigated the role of Epstein-Barr virus (EBV) in head and neck squamous cell carcinomas, and an increasing number of them have shown its presence in laryngeal tumors. The purpose of this meta-analysis was to evaluate the association of EBV with laryngeal carcinoma. The search was carried out in two databases, Scopus and PubMed, using the following terms: “Epstein-Barr virus” and “laryngeal carcinoma”. A total of 187 records were found, of which 31 were selected for meeting the inclusion and exclusion criteria. The meta-analysis yielded an overall pooled prevalence of 43.72% (95% confidence interval (CI): 34.35–53.08). Studies carried out in Europe and Eurasia had slightly higher pooled prevalence than other subgroups, while the prevalence of studies performed in developed countries was higher than in developing countries (46.37% vs. 34.02%). Furthermore, laryngeal carcinoma occurred almost three times as often among EBV-infected individuals compared to those without EBV infection (odds ratio = 2.86 (95% CI: 1.18–6.90); Begg’s test, <i>p</i> = 0.843 and Egger’s test, <i>p</i> = 0.866). Our findings support the idea that EBV is related to laryngeal carcinoma. However, further studies are needed before recognizing a definitive etiological role of EBV in the development and/or progression of laryngeal carcinomas. |
| first_indexed | 2024-03-10T05:09:47Z |
| format | Article |
| id | doaj.art-3781b08378954dafbec18c1c953bca8a |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T05:09:47Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-3781b08378954dafbec18c1c953bca8a2023-11-23T00:53:11ZengMDPI AGPathogens2076-08172021-11-011011142910.3390/pathogens10111429Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-AnalysisMarcos Antonio Pereira de Lima0Álife Diêgo Lima Silva1Antônio Carlos Silva do Nascimento Filho2Thiago Lima Cordeiro3João Pedro de Souza Bezerra4Maria Aline Barroso Rocha5Sally de França Lacerda Pinheiro6Roberto Flávio Fontenelle Pinheiro Junior7Maria do Socorro Vieira Gadelha8Cláudio Gleidiston Lima da Silva9School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Ceará, BrazilSchool of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Ceará, BrazilSchool of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Ceará, BrazilSchool of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Ceará, BrazilSchool of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Ceará, BrazilSchool of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Ceará, BrazilSchool of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Ceará, BrazilSchool of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Ceará, BrazilSchool of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Ceará, BrazilSchool of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Ceará, BrazilOver the past few decades, several publications have investigated the role of Epstein-Barr virus (EBV) in head and neck squamous cell carcinomas, and an increasing number of them have shown its presence in laryngeal tumors. The purpose of this meta-analysis was to evaluate the association of EBV with laryngeal carcinoma. The search was carried out in two databases, Scopus and PubMed, using the following terms: “Epstein-Barr virus” and “laryngeal carcinoma”. A total of 187 records were found, of which 31 were selected for meeting the inclusion and exclusion criteria. The meta-analysis yielded an overall pooled prevalence of 43.72% (95% confidence interval (CI): 34.35–53.08). Studies carried out in Europe and Eurasia had slightly higher pooled prevalence than other subgroups, while the prevalence of studies performed in developed countries was higher than in developing countries (46.37% vs. 34.02%). Furthermore, laryngeal carcinoma occurred almost three times as often among EBV-infected individuals compared to those without EBV infection (odds ratio = 2.86 (95% CI: 1.18–6.90); Begg’s test, <i>p</i> = 0.843 and Egger’s test, <i>p</i> = 0.866). Our findings support the idea that EBV is related to laryngeal carcinoma. However, further studies are needed before recognizing a definitive etiological role of EBV in the development and/or progression of laryngeal carcinomas.https://www.mdpi.com/2076-0817/10/11/1429Epstein-Barr virus (EBV)laryngeal carcinomacarcinogenesisoncovirus |
| spellingShingle | Marcos Antonio Pereira de Lima Álife Diêgo Lima Silva Antônio Carlos Silva do Nascimento Filho Thiago Lima Cordeiro João Pedro de Souza Bezerra Maria Aline Barroso Rocha Sally de França Lacerda Pinheiro Roberto Flávio Fontenelle Pinheiro Junior Maria do Socorro Vieira Gadelha Cláudio Gleidiston Lima da Silva Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis Pathogens Epstein-Barr virus (EBV) laryngeal carcinoma carcinogenesis oncovirus |
| title | Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis |
| title_full | Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis |
| title_fullStr | Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis |
| title_full_unstemmed | Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis |
| title_short | Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis |
| title_sort | epstein barr virus associated carcinoma of the larynx a systematic review with meta analysis |
| topic | Epstein-Barr virus (EBV) laryngeal carcinoma carcinogenesis oncovirus |
| url | https://www.mdpi.com/2076-0817/10/11/1429 |
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