Protease XIV abolishes NHE inhibition by empagliflozin in cardiac cells

Protease XIV abolishes NHE inhibition by empagliflozin in cardiac cells

Background: SGLT2i directly inhibit the cardiac sodium-hydrogen exchanger-1 (NHE1) in isolated ventricular cardiomyocytes (CMs). However, other studies with SGLT2i have yielded conflicting results. This may be explained by methodological factors including cell isolation techniques, cell types and am...

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Bibliographic Details
Main Authors: Sha Chen, Cees A. Schumacher, Shirley C. M. Van Amersfoorth, Jan W. T. Fiolet, Antonius Baartscheer, Marieke W. Veldkamp, Ruben Coronel, Coert J. Zuurbier
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Physiology
Subjects:
SGLT2
NHE
protease XIV
empagliflozin
cardiomyocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1179131/full

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