Osimertinib showed efficacy on contralateral multiple ground-glass nodules after segmentectomy for lung adenocarcinoma harboring primary EGFR-T790M mutation: a case report and review of the literature
Abstract Background Multiple ground-glass nodules (mGGNs) in the lung has been defined as synchronous multiple primary lung cancer (SMPLC), it is has been very difficult challenging to differentiate SMPLC from intrapulmonary metastases, and its treatment remains controversial. Case presentation We r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-022-02071-7 |
| _version_ | 1797977250876882944 |
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| author | Haijun Dong Jianbin Zhang Weiwei Min Qibin Shen |
| author_facet | Haijun Dong Jianbin Zhang Weiwei Min Qibin Shen |
| author_sort | Haijun Dong |
| collection | DOAJ |
| description | Abstract Background Multiple ground-glass nodules (mGGNs) in the lung has been defined as synchronous multiple primary lung cancer (SMPLC), it is has been very difficult challenging to differentiate SMPLC from intrapulmonary metastases, and its treatment remains controversial. Case presentation We report a case simultaneously involving mGGNs and lung adenocarcinoma harboring primary EGFR-T790M mutation, in which the patient underwent the radical resection of lesions in the left upper lung, and continued the osimertinib treatment for the residual mGGNs in all lobes of the right lung. These mGGNs displayed different responses to osimertinib. Conclusions We reported a successful strategy on the postoperative treatment for mGGNs. For those that cannot be completely resected, the chemotherapy, radiotherapy, stereotactic body radiation therapy, immunotherapy and targeted therapy have been performed instead. The EGFR-TKI therapy strategy showed significant advantages, but how to achieve even better therapeutic effect needs more researches. |
| first_indexed | 2024-04-11T05:03:59Z |
| format | Article |
| id | doaj.art-3781f4b246e64c738f7b07840c6dfeac |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-04-11T05:03:59Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-3781f4b246e64c738f7b07840c6dfeac2022-12-25T12:28:55ZengBMCJournal of Cardiothoracic Surgery1749-80902022-12-011711410.1186/s13019-022-02071-7Osimertinib showed efficacy on contralateral multiple ground-glass nodules after segmentectomy for lung adenocarcinoma harboring primary EGFR-T790M mutation: a case report and review of the literatureHaijun Dong0Jianbin Zhang1Weiwei Min2Qibin Shen3Department of Thoracic Surgery, Huzhou Central Hospital, Affiliated Central Hospital of HuZhou UniversityDepartment of Thoracic Surgery, Huzhou Central Hospital, Affiliated Central Hospital of HuZhou UniversityDepartment of Thoracic Surgery, Huzhou Central Hospital, Affiliated Central Hospital of HuZhou UniversityDepartment of Thoracic Surgery, Huzhou Central Hospital, Affiliated Central Hospital of HuZhou UniversityAbstract Background Multiple ground-glass nodules (mGGNs) in the lung has been defined as synchronous multiple primary lung cancer (SMPLC), it is has been very difficult challenging to differentiate SMPLC from intrapulmonary metastases, and its treatment remains controversial. Case presentation We report a case simultaneously involving mGGNs and lung adenocarcinoma harboring primary EGFR-T790M mutation, in which the patient underwent the radical resection of lesions in the left upper lung, and continued the osimertinib treatment for the residual mGGNs in all lobes of the right lung. These mGGNs displayed different responses to osimertinib. Conclusions We reported a successful strategy on the postoperative treatment for mGGNs. For those that cannot be completely resected, the chemotherapy, radiotherapy, stereotactic body radiation therapy, immunotherapy and targeted therapy have been performed instead. The EGFR-TKI therapy strategy showed significant advantages, but how to achieve even better therapeutic effect needs more researches.https://doi.org/10.1186/s13019-022-02071-7Multiple ground-glass nodules (mGGNs)Synchronous multiple primary lung cancer (SMPLC)Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) |
| spellingShingle | Haijun Dong Jianbin Zhang Weiwei Min Qibin Shen Osimertinib showed efficacy on contralateral multiple ground-glass nodules after segmentectomy for lung adenocarcinoma harboring primary EGFR-T790M mutation: a case report and review of the literature Journal of Cardiothoracic Surgery Multiple ground-glass nodules (mGGNs) Synchronous multiple primary lung cancer (SMPLC) Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) |
| title | Osimertinib showed efficacy on contralateral multiple ground-glass nodules after segmentectomy for lung adenocarcinoma harboring primary EGFR-T790M mutation: a case report and review of the literature |
| title_full | Osimertinib showed efficacy on contralateral multiple ground-glass nodules after segmentectomy for lung adenocarcinoma harboring primary EGFR-T790M mutation: a case report and review of the literature |
| title_fullStr | Osimertinib showed efficacy on contralateral multiple ground-glass nodules after segmentectomy for lung adenocarcinoma harboring primary EGFR-T790M mutation: a case report and review of the literature |
| title_full_unstemmed | Osimertinib showed efficacy on contralateral multiple ground-glass nodules after segmentectomy for lung adenocarcinoma harboring primary EGFR-T790M mutation: a case report and review of the literature |
| title_short | Osimertinib showed efficacy on contralateral multiple ground-glass nodules after segmentectomy for lung adenocarcinoma harboring primary EGFR-T790M mutation: a case report and review of the literature |
| title_sort | osimertinib showed efficacy on contralateral multiple ground glass nodules after segmentectomy for lung adenocarcinoma harboring primary egfr t790m mutation a case report and review of the literature |
| topic | Multiple ground-glass nodules (mGGNs) Synchronous multiple primary lung cancer (SMPLC) Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) |
| url | https://doi.org/10.1186/s13019-022-02071-7 |
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