Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor Tissue
The tumor microenvironment (TME) plays a key role in cancer development and progression, as well as contributes to the therapeutic resistance and metastasis of cancer cells. The TME is heterogeneous and consists of multiple cell types, including cancer-associated fibroblasts (CAFs), endothelial cell...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/9/2536 |
| _version_ | 1797602898402607104 |
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| author | Yoshimi Arima Satoko Matsueda Hideyuki Saya |
| author_facet | Yoshimi Arima Satoko Matsueda Hideyuki Saya |
| author_sort | Yoshimi Arima |
| collection | DOAJ |
| description | The tumor microenvironment (TME) plays a key role in cancer development and progression, as well as contributes to the therapeutic resistance and metastasis of cancer cells. The TME is heterogeneous and consists of multiple cell types, including cancer-associated fibroblasts (CAFs), endothelial cells, and immune cells, as well as various extracellular components. Recent studies have revealed cross talk between cancer cells and CAFs as well as between CAFs and other TME cells, including immune cells. Signaling by transforming growth factor-β, derived from CAFs, has recently been shown to induce remodeling of tumor tissue, including the promotion of angiogenesis and immune cell recruitment. Immunocompetent mouse cancer models that recapitulate interactions of cancer cells with the TME have provided insight into the TME network and support the development of new anticancer therapeutic strategies. Recent studies based on such models have revealed that the antitumor action of molecularly targeted agents is mediated in part by effects on the tumor immune environment. In this review, we focus on cancer cell–TME interactions in heterogeneous tumor tissue, and we provide an overview of the basis for anticancer therapeutic strategies that target the TME, including immunotherapy. |
| first_indexed | 2024-03-11T04:22:03Z |
| format | Article |
| id | doaj.art-3782d207adbf4bdb93afe4978dce791d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T04:22:03Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3782d207adbf4bdb93afe4978dce791d2023-11-17T22:41:05ZengMDPI AGCancers2072-66942023-04-01159253610.3390/cancers15092536Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor TissueYoshimi Arima0Satoko Matsueda1Hideyuki Saya2Cancer Center, Fujita Health University, Toyoake 470-1192, JapanCancer Center, Fujita Health University, Toyoake 470-1192, JapanCancer Center, Fujita Health University, Toyoake 470-1192, JapanThe tumor microenvironment (TME) plays a key role in cancer development and progression, as well as contributes to the therapeutic resistance and metastasis of cancer cells. The TME is heterogeneous and consists of multiple cell types, including cancer-associated fibroblasts (CAFs), endothelial cells, and immune cells, as well as various extracellular components. Recent studies have revealed cross talk between cancer cells and CAFs as well as between CAFs and other TME cells, including immune cells. Signaling by transforming growth factor-β, derived from CAFs, has recently been shown to induce remodeling of tumor tissue, including the promotion of angiogenesis and immune cell recruitment. Immunocompetent mouse cancer models that recapitulate interactions of cancer cells with the TME have provided insight into the TME network and support the development of new anticancer therapeutic strategies. Recent studies based on such models have revealed that the antitumor action of molecularly targeted agents is mediated in part by effects on the tumor immune environment. In this review, we focus on cancer cell–TME interactions in heterogeneous tumor tissue, and we provide an overview of the basis for anticancer therapeutic strategies that target the TME, including immunotherapy.https://www.mdpi.com/2072-6694/15/9/2536cancer-associated fibroblasttumor microenvironmentdesmoplastic stromatumor heterogeneityimmune suppressionimmunocompetent mouse model |
| spellingShingle | Yoshimi Arima Satoko Matsueda Hideyuki Saya Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor Tissue Cancers cancer-associated fibroblast tumor microenvironment desmoplastic stroma tumor heterogeneity immune suppression immunocompetent mouse model |
| title | Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor Tissue |
| title_full | Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor Tissue |
| title_fullStr | Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor Tissue |
| title_full_unstemmed | Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor Tissue |
| title_short | Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor Tissue |
| title_sort | significance of cancer associated fibroblasts in the interactions of cancer cells with the tumor microenvironment of heterogeneous tumor tissue |
| topic | cancer-associated fibroblast tumor microenvironment desmoplastic stroma tumor heterogeneity immune suppression immunocompetent mouse model |
| url | https://www.mdpi.com/2072-6694/15/9/2536 |
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