Elevated serum triglyceride and retinol-binding protein 4 levels associated with fructose-sweetened beverages in adolescents.
BACKGROUND: The metabolic effect of fructose in sugar-sweetened beverages (SSB) has been linked to de novo lipogenesis and uric acid (UA) production. OBJECTIVES: This study investigated the biological effects of SSB consumption on serum lipid profiles and retinol-binding protein 4 (RBP4) among Taiwa...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3903467?pdf=render |
| _version_ | 1798044968615411712 |
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| author | Te-Fu Chan Wei-Ting Lin Yi-Ling Chen Hsiao-Ling Huang Wei-Zeng Yang Chun-Ying Lee Meng-Hsueh Chen Tsu-Nai Wang Meng-Chuan Huang Yu-Wen Chiu Chun-Chi Huang Sharon Tsai Chih-Lung Lin Chien-Hung Lee |
| author_facet | Te-Fu Chan Wei-Ting Lin Yi-Ling Chen Hsiao-Ling Huang Wei-Zeng Yang Chun-Ying Lee Meng-Hsueh Chen Tsu-Nai Wang Meng-Chuan Huang Yu-Wen Chiu Chun-Chi Huang Sharon Tsai Chih-Lung Lin Chien-Hung Lee |
| author_sort | Te-Fu Chan |
| collection | DOAJ |
| description | BACKGROUND: The metabolic effect of fructose in sugar-sweetened beverages (SSB) has been linked to de novo lipogenesis and uric acid (UA) production. OBJECTIVES: This study investigated the biological effects of SSB consumption on serum lipid profiles and retinol-binding protein 4 (RBP4) among Taiwanese adolescents. METHODS: We evaluated the anthropometric parameters and biochemical outcomes of 200 representative adolescents (98 boys and 102 girls) who were randomly selected from a large-scale cross-sectional study. Data were analyzed using multiple regression models adjusted for covariates. RESULTS: Increased SSB consumption was associated with increased waist and hip circumferences, body mass index (BMI) values and serum UA, triglyceride (TG) and RBP4 levels. Adolescents who consumed >500 ml/day of beverages half-to-heavily sweetened with high-fructose corn syrup (HFCS) exhibited TG and RBP4 levels 22.7 mg/dl and 13.92 ng/ml higher than non-drinkers, respectively. HFCS drinkers with hyperuricemia had higher TG levels than HFCS drinkers with normal UA levels (98.6 vs. 81.6 mg/dl). The intake of HFCS-rich SSBs and high value of BMI (≥24) interactively reinforced RBP4 levels among overweight/obese adolescents. Circulating RBP4 levels were significantly correlated with weight-related outcomes and TG and UA concentration among HFCS drinkers (r = 0.253 to 0.404), but not among non-drinkers. CONCLUSIONS: High-quantity HFCS-rich beverage consumption is associated with higher TG and RBP4 levels. Hyperuricemia is likely to intensify the influence of HFCS-rich SSB intake on elevated TG levels, and in overweight and obese adolescents, high BMI may modify the action of fructose on higher circulating levels of RBP4. |
| first_indexed | 2024-04-11T23:12:56Z |
| format | Article |
| id | doaj.art-378569036cfa42d78322ef18e9894496 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T23:12:56Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-378569036cfa42d78322ef18e98944962022-12-22T03:57:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8200410.1371/journal.pone.0082004Elevated serum triglyceride and retinol-binding protein 4 levels associated with fructose-sweetened beverages in adolescents.Te-Fu ChanWei-Ting LinYi-Ling ChenHsiao-Ling HuangWei-Zeng YangChun-Ying LeeMeng-Hsueh ChenTsu-Nai WangMeng-Chuan HuangYu-Wen ChiuChun-Chi HuangSharon TsaiChih-Lung LinChien-Hung LeeBACKGROUND: The metabolic effect of fructose in sugar-sweetened beverages (SSB) has been linked to de novo lipogenesis and uric acid (UA) production. OBJECTIVES: This study investigated the biological effects of SSB consumption on serum lipid profiles and retinol-binding protein 4 (RBP4) among Taiwanese adolescents. METHODS: We evaluated the anthropometric parameters and biochemical outcomes of 200 representative adolescents (98 boys and 102 girls) who were randomly selected from a large-scale cross-sectional study. Data were analyzed using multiple regression models adjusted for covariates. RESULTS: Increased SSB consumption was associated with increased waist and hip circumferences, body mass index (BMI) values and serum UA, triglyceride (TG) and RBP4 levels. Adolescents who consumed >500 ml/day of beverages half-to-heavily sweetened with high-fructose corn syrup (HFCS) exhibited TG and RBP4 levels 22.7 mg/dl and 13.92 ng/ml higher than non-drinkers, respectively. HFCS drinkers with hyperuricemia had higher TG levels than HFCS drinkers with normal UA levels (98.6 vs. 81.6 mg/dl). The intake of HFCS-rich SSBs and high value of BMI (≥24) interactively reinforced RBP4 levels among overweight/obese adolescents. Circulating RBP4 levels were significantly correlated with weight-related outcomes and TG and UA concentration among HFCS drinkers (r = 0.253 to 0.404), but not among non-drinkers. CONCLUSIONS: High-quantity HFCS-rich beverage consumption is associated with higher TG and RBP4 levels. Hyperuricemia is likely to intensify the influence of HFCS-rich SSB intake on elevated TG levels, and in overweight and obese adolescents, high BMI may modify the action of fructose on higher circulating levels of RBP4.http://europepmc.org/articles/PMC3903467?pdf=render |
| spellingShingle | Te-Fu Chan Wei-Ting Lin Yi-Ling Chen Hsiao-Ling Huang Wei-Zeng Yang Chun-Ying Lee Meng-Hsueh Chen Tsu-Nai Wang Meng-Chuan Huang Yu-Wen Chiu Chun-Chi Huang Sharon Tsai Chih-Lung Lin Chien-Hung Lee Elevated serum triglyceride and retinol-binding protein 4 levels associated with fructose-sweetened beverages in adolescents. PLoS ONE |
| title | Elevated serum triglyceride and retinol-binding protein 4 levels associated with fructose-sweetened beverages in adolescents. |
| title_full | Elevated serum triglyceride and retinol-binding protein 4 levels associated with fructose-sweetened beverages in adolescents. |
| title_fullStr | Elevated serum triglyceride and retinol-binding protein 4 levels associated with fructose-sweetened beverages in adolescents. |
| title_full_unstemmed | Elevated serum triglyceride and retinol-binding protein 4 levels associated with fructose-sweetened beverages in adolescents. |
| title_short | Elevated serum triglyceride and retinol-binding protein 4 levels associated with fructose-sweetened beverages in adolescents. |
| title_sort | elevated serum triglyceride and retinol binding protein 4 levels associated with fructose sweetened beverages in adolescents |
| url | http://europepmc.org/articles/PMC3903467?pdf=render |
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