Ethanol Impairs NRF2/Antioxidant and Growth Signaling in the Intact Placenta In Vivo and in Human Trophoblasts

Ethanol Impairs NRF2/Antioxidant and Growth Signaling in the Intact Placenta In Vivo and in Human Trophoblasts

NRF2 is a redox-sensitive transcription factor that depending on the duration or magnitude of the stress, either translocates to the nucleus (beneficial) or is degraded in the cytosol (harmful). However, the role of NRF2-based mechanism(s) under ethanol (E)-induced developmental toxicity in the plac...

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Bibliographic Details
Main Authors: Sambantham Shanmugam, Dhyanesh Patel, John M. Wolpert, Caezaan Keshvani, Xiaobo Liu, Susan E. Bergeson, Srivatsan Kidambi, Lenin Mahimainathan, George I. Henderson, Madhusudhanan Narasimhan
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Biomolecules
Subjects:
nrf2
placenta
ethanol
trophoblasts
prenatal alcohol
cyclin-d1
p21
Online Access:https://www.mdpi.com/2218-273X/9/11/669

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