Association Between Tumor Mutation Profile and Clinical Outcomes Among Hispanic-Latino Patients With Metastatic Colorectal Cancer
In the United States, CRC is the third most common type of cancer and the second leading cause of cancer-related death. Although the incidence of CRC among the Hispanic population has been declining, recently, a dramatic increase in CRC incidents among HL younger than 50 years of age has been report...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.772225/full |
| _version_ | 1798025066890395648 |
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| author | Alexander Philipovskiy Reshad Ghafouri Alok Kumar Dwivedi Luis Alvarado Richard McCallum Felipe Maegawa Ioannis T. Konstantinidis Nawar Hakim Scott Shurmur Sanjay Awasthi Sumit Gaur Javier Corral |
| author_facet | Alexander Philipovskiy Reshad Ghafouri Alok Kumar Dwivedi Luis Alvarado Richard McCallum Felipe Maegawa Ioannis T. Konstantinidis Nawar Hakim Scott Shurmur Sanjay Awasthi Sumit Gaur Javier Corral |
| author_sort | Alexander Philipovskiy |
| collection | DOAJ |
| description | In the United States, CRC is the third most common type of cancer and the second leading cause of cancer-related death. Although the incidence of CRC among the Hispanic population has been declining, recently, a dramatic increase in CRC incidents among HL younger than 50 years of age has been reported. The incidence of early-onset CRC is more significant in HL population (45%) than in non-Hispanic Whites (27%) and African-Americans (15%). The reason for these racial disparities and the biology of CRC in the HL are not well understood. We performed this study to understand the biology of the disease in HL patients. We analyzed formalin-fixed paraffin-embedded tumor tissue samples from 52 HL patients with mCRC. We compared the results with individual patient clinical histories and outcomes. We identified commonly altered genes in HL patients (APC, TP53, KRAS, GNAS, and NOTCH). Importantly, mutation frequencies in the APC gene were significantly higher among HL patients. The combination of mutations in the APC, NOTCH, and KRAS genes in the same tumors was associated with a higher risk of progression after first-line of chemotherapy and overall survival. Our data support the notion that the molecular drivers of CRC might be different in HL patients. |
| first_indexed | 2024-04-11T18:12:49Z |
| format | Article |
| id | doaj.art-3787cd8b23e2459987c96fba00129f4f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T18:12:49Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3787cd8b23e2459987c96fba00129f4f2022-12-22T04:10:03ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-01-011110.3389/fonc.2021.772225772225Association Between Tumor Mutation Profile and Clinical Outcomes Among Hispanic-Latino Patients With Metastatic Colorectal CancerAlexander Philipovskiy0Reshad Ghafouri1Alok Kumar Dwivedi2Luis Alvarado3Richard McCallum4Felipe Maegawa5Ioannis T. Konstantinidis6Nawar Hakim7Scott Shurmur8Sanjay Awasthi9Sumit Gaur10Javier Corral11Department of Internal Medicine, Division of Hematology-Oncology, Texas Tech University Health Sciences Center Lubbock, Lubbock, TX, United StatesDepartment of Internal Medicine, Division of Hematology-Oncology, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United StatesDepartment of Molecular and Translational Medicine, Division of Biostatistics & Epidemiology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United StatesDepartment of Molecular and Translational Medicine, Division of Biostatistics & Epidemiology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United StatesDepartment of Internal Medicine, Division of Gastroenterology, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United StatesDepartment of Surgery, Southern Arizona VA Health Care System, University of Arizona, Tucson, AZ, United StatesDepartment of Surgery, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United StatesDepartment of Pathology, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United StatesDepartment of Internal Medicine, Division of Hematology-Oncology, Texas Tech University Health Sciences Center Lubbock, Lubbock, TX, United StatesDepartment of Internal Medicine, Division of Hematology-Oncology, Texas Tech University Health Sciences Center Lubbock, Lubbock, TX, United StatesDepartment of Internal Medicine, Division of Hematology-Oncology, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United StatesDepartment of Internal Medicine, Division of Hematology-Oncology, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United StatesIn the United States, CRC is the third most common type of cancer and the second leading cause of cancer-related death. Although the incidence of CRC among the Hispanic population has been declining, recently, a dramatic increase in CRC incidents among HL younger than 50 years of age has been reported. The incidence of early-onset CRC is more significant in HL population (45%) than in non-Hispanic Whites (27%) and African-Americans (15%). The reason for these racial disparities and the biology of CRC in the HL are not well understood. We performed this study to understand the biology of the disease in HL patients. We analyzed formalin-fixed paraffin-embedded tumor tissue samples from 52 HL patients with mCRC. We compared the results with individual patient clinical histories and outcomes. We identified commonly altered genes in HL patients (APC, TP53, KRAS, GNAS, and NOTCH). Importantly, mutation frequencies in the APC gene were significantly higher among HL patients. The combination of mutations in the APC, NOTCH, and KRAS genes in the same tumors was associated with a higher risk of progression after first-line of chemotherapy and overall survival. Our data support the notion that the molecular drivers of CRC might be different in HL patients.https://www.frontiersin.org/articles/10.3389/fonc.2021.772225/fullcolon cancerHispanic-Latino patientsAPCTP53KRASGnas |
| spellingShingle | Alexander Philipovskiy Reshad Ghafouri Alok Kumar Dwivedi Luis Alvarado Richard McCallum Felipe Maegawa Ioannis T. Konstantinidis Nawar Hakim Scott Shurmur Sanjay Awasthi Sumit Gaur Javier Corral Association Between Tumor Mutation Profile and Clinical Outcomes Among Hispanic-Latino Patients With Metastatic Colorectal Cancer Frontiers in Oncology colon cancer Hispanic-Latino patients APC TP53 KRAS Gnas |
| title | Association Between Tumor Mutation Profile and Clinical Outcomes Among Hispanic-Latino Patients With Metastatic Colorectal Cancer |
| title_full | Association Between Tumor Mutation Profile and Clinical Outcomes Among Hispanic-Latino Patients With Metastatic Colorectal Cancer |
| title_fullStr | Association Between Tumor Mutation Profile and Clinical Outcomes Among Hispanic-Latino Patients With Metastatic Colorectal Cancer |
| title_full_unstemmed | Association Between Tumor Mutation Profile and Clinical Outcomes Among Hispanic-Latino Patients With Metastatic Colorectal Cancer |
| title_short | Association Between Tumor Mutation Profile and Clinical Outcomes Among Hispanic-Latino Patients With Metastatic Colorectal Cancer |
| title_sort | association between tumor mutation profile and clinical outcomes among hispanic latino patients with metastatic colorectal cancer |
| topic | colon cancer Hispanic-Latino patients APC TP53 KRAS Gnas |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.772225/full |
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