Early detection of hepatocellular carcinoma via no end-repair enzymatic methylation sequencing of cell-free DNA and pre-trained neural network

Early detection of hepatocellular carcinoma via no end-repair enzymatic methylation sequencing of cell-free DNA and pre-trained neural network

Abstract Background Early detection of hepatocellular carcinoma (HCC) is important in order to improve patient prognosis and survival rate. Methylation sequencing combined with neural networks to identify cell-free DNA (cfDNA) carrying aberrant methylation offers an appealing and non-invasive approa...

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Bibliographic Details
Main Authors: Zhenzhong Deng, Yongkun Ji, Bing Han, Zhongming Tan, Yuqi Ren, Jinghan Gao, Nan Chen, Cong Ma, Yichi Zhang, Yunhai Yao, Hong Lu, Heqing Huang, Midie Xu, Lei Chen, Leizhen Zheng, Jianchun Gu, Deyi Xiong, Jianxin Zhao, Jinyang Gu, Zutao Chen, Ke Wang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Genome Medicine
Subjects:
Hepatocellular carcinoma
Early detection
Cell-free DNA
Circulating tumor DNA
Whole-genome methylation sequencing
Enzymatic conversion
Online Access:https://doi.org/10.1186/s13073-023-01238-8

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