New insights into the metabolism of Th17 cells
AbstractT helper 17 (Th17) cells are IL-17-producing CD4 T cells that play a crucial role in autoimmune diseases. IL-17 is a key cytokine for host protection against mucosal and skin infection but is also one of the major pathogenic cytokines. IL-1 and IL-23 are requisite for stimulating pathogenic...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-01-01
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| Series: | Immunological Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/25785826.2022.2140503 |
| _version_ | 1811168395522998272 |
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| author | Michihito Kono |
| author_facet | Michihito Kono |
| author_sort | Michihito Kono |
| collection | DOAJ |
| description | AbstractT helper 17 (Th17) cells are IL-17-producing CD4 T cells that play a crucial role in autoimmune diseases. IL-17 is a key cytokine for host protection against mucosal and skin infection but is also one of the major pathogenic cytokines. IL-1 and IL-23 are requisite for stimulating pathogenic Th17 cell differentiation and proliferation. Therapeutics targeting the IL-17/IL-23 pathway are widely used clinically for the treatment of autoimmune diseases. Besides IL-17, pathogenic Th17 cells produce granulocyte-macrophage colony-stimulating factor, tumor necrosis factor α, interferon γ, IL-21 and IL-22. However, Th17-targeted therapy has not yet been established. T cell metabolism orchestrates T cell survival, cell differentiation, epigenetic change and function and each T cell subset favors a particular metabolic pathway. Recent studies have provided novel insights into the role of T cell metabolism in the pathogenesis of autoimmune diseases. The current review focuses on the role of Th17 cell metabolism in autoimmune diseases, particularly glycolysis, amino acid metabolism, lipid metabolism, as well as the regulators of these processes, including mTORC1. Therapeutics targeting T cell metabolism in autoimmune diseases could serve as a possible treatment option for patients who are refractory to or unresponsive to conventional therapy. |
| first_indexed | 2024-04-10T16:25:35Z |
| format | Article |
| id | doaj.art-3788c0130a494eee86fee6f53b409ccb |
| institution | Directory Open Access Journal |
| issn | 2578-5826 |
| language | English |
| last_indexed | 2024-04-10T16:25:35Z |
| publishDate | 2023-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Immunological Medicine |
| spelling | doaj.art-3788c0130a494eee86fee6f53b409ccb2023-02-09T05:34:36ZengTaylor & Francis GroupImmunological Medicine2578-58262023-01-01461152410.1080/25785826.2022.2140503New insights into the metabolism of Th17 cellsMichihito Kono0Faculty of Medicine, Department of Rheumatology, Endocrinology and Nephrology, Hokkaido University, Sapporo, JapanAbstractT helper 17 (Th17) cells are IL-17-producing CD4 T cells that play a crucial role in autoimmune diseases. IL-17 is a key cytokine for host protection against mucosal and skin infection but is also one of the major pathogenic cytokines. IL-1 and IL-23 are requisite for stimulating pathogenic Th17 cell differentiation and proliferation. Therapeutics targeting the IL-17/IL-23 pathway are widely used clinically for the treatment of autoimmune diseases. Besides IL-17, pathogenic Th17 cells produce granulocyte-macrophage colony-stimulating factor, tumor necrosis factor α, interferon γ, IL-21 and IL-22. However, Th17-targeted therapy has not yet been established. T cell metabolism orchestrates T cell survival, cell differentiation, epigenetic change and function and each T cell subset favors a particular metabolic pathway. Recent studies have provided novel insights into the role of T cell metabolism in the pathogenesis of autoimmune diseases. The current review focuses on the role of Th17 cell metabolism in autoimmune diseases, particularly glycolysis, amino acid metabolism, lipid metabolism, as well as the regulators of these processes, including mTORC1. Therapeutics targeting T cell metabolism in autoimmune diseases could serve as a possible treatment option for patients who are refractory to or unresponsive to conventional therapy.https://www.tandfonline.com/doi/10.1080/25785826.2022.2140503Cellular metabolismTh17IL-17glycolysisglutaminolysis |
| spellingShingle | Michihito Kono New insights into the metabolism of Th17 cells Immunological Medicine Cellular metabolism Th17 IL-17 glycolysis glutaminolysis |
| title | New insights into the metabolism of Th17 cells |
| title_full | New insights into the metabolism of Th17 cells |
| title_fullStr | New insights into the metabolism of Th17 cells |
| title_full_unstemmed | New insights into the metabolism of Th17 cells |
| title_short | New insights into the metabolism of Th17 cells |
| title_sort | new insights into the metabolism of th17 cells |
| topic | Cellular metabolism Th17 IL-17 glycolysis glutaminolysis |
| url | https://www.tandfonline.com/doi/10.1080/25785826.2022.2140503 |
| work_keys_str_mv | AT michihitokono newinsightsintothemetabolismofth17cells |