Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it.

Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it.

IFN-γ is a major cytokine that mediates resistance against the intracellular parasite Toxoplasma gondii. The p65 guanylate-binding proteins (GBPs) are strongly induced by IFN-γ. We studied the behavior of murine GBP1 (mGBP1) upon infection with T. gondii in vitro and confirmed that IFN-γ-dependent r...

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Bibliographic Details
Main Authors: Sebastian Virreira Winter, Wendy Niedelman, Kirk D Jensen, Emily E Rosowski, Lindsay Julien, Eric Spooner, Kacey Caradonna, Barbara A Burleigh, Jeroen P J Saeij, Hidde L Ploegh, Eva-Maria Frickel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3169597?pdf=render

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