Drug/Lead Compound Hydroxymethylation as a Simple Approach to Enhance Pharmacodynamic and Pharmacokinetic Properties

Drug/Lead Compound Hydroxymethylation as a Simple Approach to Enhance Pharmacodynamic and Pharmacokinetic Properties

Hydroxymethylation is a simple chemical reaction, in which the introduction of the hydroxymethyl group can lead to physical–chemical property changes and offer several therapeutic advantages, contributing to the improved biological activity of drugs. There are many examples in the literature of the...

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Bibliographic Details
Main Authors: Soraya S. Santos, Rodrigo V. Gonzaga, Cauê B. Scarim, Jeanine Giarolla, Marina C. Primi, Chung M. Chin, Elizabeth I. Ferreira
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Chemistry
Subjects:
hydroxymethylation
hydroxymethyl compounds
hydroxymethyl drug
prodrug design
hydroxymethylnitrofurazone
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.734983/full

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