Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies
Glioblastoma (GBM) is the most common and lethal malignant tumor of the central nervous system in adults. Conventional therapies, including surgery, radiotherapy, and chemotherapy, have limited success in ameliorating patient survival. The immunosuppressive tumor microenvironment, which is infiltrat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.994698/full |
| _version_ | 1797894318988460032 |
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| author | Boyuan Huang Jin Zhang Wenjing Zong Sisi Chen Zhitao Zong Xiaojun Zeng Hongbo Zhang |
| author_facet | Boyuan Huang Jin Zhang Wenjing Zong Sisi Chen Zhitao Zong Xiaojun Zeng Hongbo Zhang |
| author_sort | Boyuan Huang |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most common and lethal malignant tumor of the central nervous system in adults. Conventional therapies, including surgery, radiotherapy, and chemotherapy, have limited success in ameliorating patient survival. The immunosuppressive tumor microenvironment, which is infiltrated by a variety of myeloid cells, has been considered a crucial obstacle to current treatment. Recently, immunotherapy, which has achieved great success in hematological malignancies and some solid cancers, has garnered extensive attention for the treatment of GBM. In this review, we will present evidence on the features and functions of different populations of myeloid cells, and on current clinical advances in immunotherapies for glioblastoma. |
| first_indexed | 2024-04-10T07:07:01Z |
| format | Article |
| id | doaj.art-378add9ce0bb4d1f9153d27665d5d6ab |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T07:07:01Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-378add9ce0bb4d1f9153d27665d5d6ab2023-02-27T06:13:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.994698994698Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategiesBoyuan Huang0Jin Zhang1Wenjing Zong2Sisi Chen3Zhitao Zong4Xiaojun Zeng5Hongbo Zhang6Department of Neurosurgery, Capital Medical University Electric Power Teaching Hospital/State Grid Beijing Electric Power Hospital, Beijing, ChinaDepartment of Neurosurgery, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of neurosurgery, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, ChinaDepartment of neurosurgery, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, ChinaDepartment of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaGlioblastoma (GBM) is the most common and lethal malignant tumor of the central nervous system in adults. Conventional therapies, including surgery, radiotherapy, and chemotherapy, have limited success in ameliorating patient survival. The immunosuppressive tumor microenvironment, which is infiltrated by a variety of myeloid cells, has been considered a crucial obstacle to current treatment. Recently, immunotherapy, which has achieved great success in hematological malignancies and some solid cancers, has garnered extensive attention for the treatment of GBM. In this review, we will present evidence on the features and functions of different populations of myeloid cells, and on current clinical advances in immunotherapies for glioblastoma.https://www.frontiersin.org/articles/10.3389/fimmu.2023.994698/fullmyeloid cellsimmunosuppressivetumor microenvironmentglioblastomaimmunotherapies |
| spellingShingle | Boyuan Huang Jin Zhang Wenjing Zong Sisi Chen Zhitao Zong Xiaojun Zeng Hongbo Zhang Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies Frontiers in Immunology myeloid cells immunosuppressive tumor microenvironment glioblastoma immunotherapies |
| title | Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies |
| title_full | Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies |
| title_fullStr | Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies |
| title_full_unstemmed | Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies |
| title_short | Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies |
| title_sort | myeloidcells in the immunosuppressive microenvironment in glioblastoma the characteristics and therapeutic strategies |
| topic | myeloid cells immunosuppressive tumor microenvironment glioblastoma immunotherapies |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.994698/full |
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