Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies
Photodynamic therapy is one of the more unique cancer treatment options available in today’s arsenal against this devastating disease. It has historically been explored in cutaneous lesions due to the possibility of focal/specific effects and minimization of adverse events. Advances in drug delivery...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/14/8/772 |
| _version_ | 1827684353077936128 |
|---|---|
| author | Isabella Portugal Sona Jain Patrícia Severino Ronny Priefer |
| author_facet | Isabella Portugal Sona Jain Patrícia Severino Ronny Priefer |
| author_sort | Isabella Portugal |
| collection | DOAJ |
| description | Photodynamic therapy is one of the more unique cancer treatment options available in today’s arsenal against this devastating disease. It has historically been explored in cutaneous lesions due to the possibility of focal/specific effects and minimization of adverse events. Advances in drug delivery have mostly been based on biomaterials, such as liposomal and hybrid lipoidal vesicles, nanoemulsions, microneedling, and laser-assisted photosensitizer delivery systems. This review summarizes the most promising approaches to enhancing the photosensitizers’ transdermal delivery efficacy for the photodynamic treatment for cutaneous pre-cancerous lesions and skin cancers. Additionally, discussions on strategies and advantages in these approaches, as well as summarized challenges, perspectives, and translational potential for future applications, will be discussed. |
| first_indexed | 2024-03-10T08:29:05Z |
| format | Article |
| id | doaj.art-378beb9d8e1e4e2f8a1a894164a6e64a |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T08:29:05Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-378beb9d8e1e4e2f8a1a894164a6e64a2023-11-22T09:11:35ZengMDPI AGPharmaceuticals1424-82472021-08-0114877210.3390/ph14080772Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous MalignanciesIsabella Portugal0Sona Jain1Patrícia Severino2Ronny Priefer3Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju 49032-490, BrazilPrograma de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju 49032-490, BrazilPrograma de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju 49032-490, BrazilMassachusetts College of Pharmacy and Health Sciences, University, Boston, MA 02115, USAPhotodynamic therapy is one of the more unique cancer treatment options available in today’s arsenal against this devastating disease. It has historically been explored in cutaneous lesions due to the possibility of focal/specific effects and minimization of adverse events. Advances in drug delivery have mostly been based on biomaterials, such as liposomal and hybrid lipoidal vesicles, nanoemulsions, microneedling, and laser-assisted photosensitizer delivery systems. This review summarizes the most promising approaches to enhancing the photosensitizers’ transdermal delivery efficacy for the photodynamic treatment for cutaneous pre-cancerous lesions and skin cancers. Additionally, discussions on strategies and advantages in these approaches, as well as summarized challenges, perspectives, and translational potential for future applications, will be discussed.https://www.mdpi.com/1424-8247/14/8/772photodynamic therapydrug deliverytransdermalcutaneouscancer |
| spellingShingle | Isabella Portugal Sona Jain Patrícia Severino Ronny Priefer Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies Pharmaceuticals photodynamic therapy drug delivery transdermal cutaneous cancer |
| title | Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies |
| title_full | Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies |
| title_fullStr | Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies |
| title_full_unstemmed | Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies |
| title_short | Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies |
| title_sort | micro and nano based transdermal delivery systems of photosensitizing drugs for the treatment of cutaneous malignancies |
| topic | photodynamic therapy drug delivery transdermal cutaneous cancer |
| url | https://www.mdpi.com/1424-8247/14/8/772 |
| work_keys_str_mv | AT isabellaportugal microandnanobasedtransdermaldeliverysystemsofphotosensitizingdrugsforthetreatmentofcutaneousmalignancies AT sonajain microandnanobasedtransdermaldeliverysystemsofphotosensitizingdrugsforthetreatmentofcutaneousmalignancies AT patriciaseverino microandnanobasedtransdermaldeliverysystemsofphotosensitizingdrugsforthetreatmentofcutaneousmalignancies AT ronnypriefer microandnanobasedtransdermaldeliverysystemsofphotosensitizingdrugsforthetreatmentofcutaneousmalignancies |