Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological Testing
Asymptomatic individuals with coronavirus disease (COVID-19) have been identified via nucleic acid testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the epidemiologic characteristics and viral shedding pattern of asymptomatic patients remain largely unknown. In this...
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| Format: | Article |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpubh.2020.00267/full |
| _version_ | 1818309658046103552 |
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| author | Jinru Wu Jinru Wu Xinyi Liu Dan Zhou Guangqian Qiu Miao Dai Qingting Yang Zhonghui Pan Ning Zhou Pa Wu |
| author_facet | Jinru Wu Jinru Wu Xinyi Liu Dan Zhou Guangqian Qiu Miao Dai Qingting Yang Zhonghui Pan Ning Zhou Pa Wu |
| author_sort | Jinru Wu |
| collection | DOAJ |
| description | Asymptomatic individuals with coronavirus disease (COVID-19) have been identified via nucleic acid testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the epidemiologic characteristics and viral shedding pattern of asymptomatic patients remain largely unknown. In this study, serological testing was applied when identifying nine asymptomatic cases of COVID-19 who showed persistent negative RT-PCR test results for SARS-CoV-2 nucleic acid and no symptoms of COVID-19. Two asymptomatic cases were presumed to be index patients who had cleared the virus when their close contacts developed symptoms of COVID-19. Three of the asymptomatic cases were local individuals who spontaneously recovered before their presumed index patients developed symptoms of COVID-19. This report presents the epidemiologic and clinical characteristics of asymptomatic individuals with SARS-CoV-2 infection that were undetected on RT-PCR tests in previous epidemiologic investigations probably due to the transient viral shedding duration. |
| first_indexed | 2024-12-13T07:33:40Z |
| format | Article |
| id | doaj.art-378c1ede4b2c4ec397714fa73eb9c065 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-13T07:33:40Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-378c1ede4b2c4ec397714fa73eb9c0652022-12-21T23:55:08ZengFrontiers Media S.A.Frontiers in Public Health2296-25652020-06-01810.3389/fpubh.2020.00267541282Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological TestingJinru Wu0Jinru Wu1Xinyi Liu2Dan Zhou3Guangqian Qiu4Miao Dai5Qingting Yang6Zhonghui Pan7Ning Zhou8Pa Wu9College of Life Science, Hunan Normal University, Changsha, ChinaLoudi Center for Disease Control and Prevention, Loudi, ChinaCollege of Life Science, Hunan Normal University, Changsha, ChinaLoudi Center for Disease Control and Prevention, Loudi, ChinaLoudi Center for Disease Control and Prevention, Loudi, ChinaLoudi Center for Disease Control and Prevention, Loudi, ChinaLoudi Center for Disease Control and Prevention, Loudi, ChinaXinhua Center for Disease Control and Prevention, Xinhua, ChinaDepartment of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, ChinaCollege of Life Science, Hunan Normal University, Changsha, ChinaAsymptomatic individuals with coronavirus disease (COVID-19) have been identified via nucleic acid testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the epidemiologic characteristics and viral shedding pattern of asymptomatic patients remain largely unknown. In this study, serological testing was applied when identifying nine asymptomatic cases of COVID-19 who showed persistent negative RT-PCR test results for SARS-CoV-2 nucleic acid and no symptoms of COVID-19. Two asymptomatic cases were presumed to be index patients who had cleared the virus when their close contacts developed symptoms of COVID-19. Three of the asymptomatic cases were local individuals who spontaneously recovered before their presumed index patients developed symptoms of COVID-19. This report presents the epidemiologic and clinical characteristics of asymptomatic individuals with SARS-CoV-2 infection that were undetected on RT-PCR tests in previous epidemiologic investigations probably due to the transient viral shedding duration.https://www.frontiersin.org/article/10.3389/fpubh.2020.00267/fullCOVID-19asymptomaticserological testSARS-CoV-2reverse transcription polymerase chain reaction |
| spellingShingle | Jinru Wu Jinru Wu Xinyi Liu Dan Zhou Guangqian Qiu Miao Dai Qingting Yang Zhonghui Pan Ning Zhou Pa Wu Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological Testing Frontiers in Public Health COVID-19 asymptomatic serological test SARS-CoV-2 reverse transcription polymerase chain reaction |
| title | Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological Testing |
| title_full | Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological Testing |
| title_fullStr | Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological Testing |
| title_full_unstemmed | Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological Testing |
| title_short | Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological Testing |
| title_sort | identification of rt pcr negative asymptomatic covid 19 patients via serological testing |
| topic | COVID-19 asymptomatic serological test SARS-CoV-2 reverse transcription polymerase chain reaction |
| url | https://www.frontiersin.org/article/10.3389/fpubh.2020.00267/full |
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