Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population
<p>Abstract</p> <p>Background</p> <p>This study was designed to investigate an association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of gastric and colorectal cancer in the Korean population.</p> <p>Methods</p...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-05-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/10/236 |
| _version_ | 1818524732254846976 |
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| author | Hwang Jun Shim Hyun Choi Jin-Su Piao Jin-Mei Song Hye-Rim Kim Hee Kweon Sun-Seog Shin Min-Ho Cui Lian-Hua Kim Hyeong-Rok Park Young-Kyu Kim Soo-Hyun |
| author_facet | Hwang Jun Shim Hyun Choi Jin-Su Piao Jin-Mei Song Hye-Rim Kim Hee Kweon Sun-Seog Shin Min-Ho Cui Lian-Hua Kim Hyeong-Rok Park Young-Kyu Kim Soo-Hyun |
| author_sort | Hwang Jun |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>This study was designed to investigate an association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of gastric and colorectal cancer in the Korean population.</p> <p>Methods</p> <p>We conducted a population-based large-scale case-control study involving 2,213 patients with newly diagnosed gastric cancer, 1,829 patients with newly diagnosed colorectal cancer, and 1,700 healthy controls. Genotyping was performed with peripheral blood DNA for MTHFR C677T polymorphisms. The statistical significance was estimated by logistic regression analysis.</p> <p>Results</p> <p>The MTHFR C677T frequencies of CC, CT, and TT genotypes were 35.2%, 47.5%, and 17.3% among stomach cancer, 34%, 50.5%, and 15.5% in colorectal cancer, and 31.8%, 50.7%, and 17.5% in the controls, respectively. The MTHFR 677TT genotype showed a weak opposite association with colorectal cancer compared to the homozygous CC genotype [adjusted age and sex odds ratio (OR) = 0.792, 95% confidence interval (CI) = 0.638-0.984, <it>P </it>= 0.035]. Subjects with the MTHFR 677CT showed a significantly reduced risk of gastric cancer compared whose with the 677CC genotype (age- and sex-adjusted OR = 0.810; 95% CI = 0.696-0.942, <it>P </it>= 0.006). We also observed no significant interactions between the MTHFR C677T polymorphism and smoking or drinking in the risk of gastric and colorectal cancer.</p> <p>Conclusions</p> <p>The T allele was found to provide a weak protective association with gastric cancer and colorectal cancer.</p> |
| first_indexed | 2024-12-11T06:00:45Z |
| format | Article |
| id | doaj.art-378ead180c124ade9f613f4889b89f17 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-11T06:00:45Z |
| publishDate | 2010-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-378ead180c124ade9f613f4889b89f172022-12-22T01:18:29ZengBMCBMC Cancer1471-24072010-05-0110123610.1186/1471-2407-10-236Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean populationHwang JunShim HyunChoi Jin-SuPiao Jin-MeiSong Hye-RimKim HeeKweon Sun-SeogShin Min-HoCui Lian-HuaKim Hyeong-RokPark Young-KyuKim Soo-Hyun<p>Abstract</p> <p>Background</p> <p>This study was designed to investigate an association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of gastric and colorectal cancer in the Korean population.</p> <p>Methods</p> <p>We conducted a population-based large-scale case-control study involving 2,213 patients with newly diagnosed gastric cancer, 1,829 patients with newly diagnosed colorectal cancer, and 1,700 healthy controls. Genotyping was performed with peripheral blood DNA for MTHFR C677T polymorphisms. The statistical significance was estimated by logistic regression analysis.</p> <p>Results</p> <p>The MTHFR C677T frequencies of CC, CT, and TT genotypes were 35.2%, 47.5%, and 17.3% among stomach cancer, 34%, 50.5%, and 15.5% in colorectal cancer, and 31.8%, 50.7%, and 17.5% in the controls, respectively. The MTHFR 677TT genotype showed a weak opposite association with colorectal cancer compared to the homozygous CC genotype [adjusted age and sex odds ratio (OR) = 0.792, 95% confidence interval (CI) = 0.638-0.984, <it>P </it>= 0.035]. Subjects with the MTHFR 677CT showed a significantly reduced risk of gastric cancer compared whose with the 677CC genotype (age- and sex-adjusted OR = 0.810; 95% CI = 0.696-0.942, <it>P </it>= 0.006). We also observed no significant interactions between the MTHFR C677T polymorphism and smoking or drinking in the risk of gastric and colorectal cancer.</p> <p>Conclusions</p> <p>The T allele was found to provide a weak protective association with gastric cancer and colorectal cancer.</p>http://www.biomedcentral.com/1471-2407/10/236 |
| spellingShingle | Hwang Jun Shim Hyun Choi Jin-Su Piao Jin-Mei Song Hye-Rim Kim Hee Kweon Sun-Seog Shin Min-Ho Cui Lian-Hua Kim Hyeong-Rok Park Young-Kyu Kim Soo-Hyun Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population BMC Cancer |
| title | Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population |
| title_full | Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population |
| title_fullStr | Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population |
| title_full_unstemmed | Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population |
| title_short | Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population |
| title_sort | methylenetetrahydrofolate reductase c677t polymorphism in patients with gastric and colorectal cancer in a korean population |
| url | http://www.biomedcentral.com/1471-2407/10/236 |
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