Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients.
BACKGROUND:Direct-acting antivirals (DAA) have demonstrated high efficacy to achieve sustained virological response (SVR) in chronic hepatitis C patients. We aim to assess the change in health-related quality of life (HRQoL) among patients successfully treated, and to identify predictors of this var...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6177189?pdf=render |
| _version_ | 1818188991820726272 |
|---|---|
| author | Regina Juanbeltz Iván Martínez-Baz Ramón San Miguel Silvia Goñi-Esarte Juan Manuel Cabasés Jesús Castilla |
| author_facet | Regina Juanbeltz Iván Martínez-Baz Ramón San Miguel Silvia Goñi-Esarte Juan Manuel Cabasés Jesús Castilla |
| author_sort | Regina Juanbeltz |
| collection | DOAJ |
| description | BACKGROUND:Direct-acting antivirals (DAA) have demonstrated high efficacy to achieve sustained virological response (SVR) in chronic hepatitis C patients. We aim to assess the change in health-related quality of life (HRQoL) among patients successfully treated, and to identify predictors of this variation. METHODS:In a prospective observational study, patients with chronic hepatitis C who started DAA therapy between May 2016 and April 2017 completed the EQ-5D-5L questionnaire at baseline and 12 weeks after the end of therapy before knowing the virological result. Analysis included all patients with SVR. RESULTS:Median baseline EQ-5D-5L scores of the 206 enrolled patients were 0.857 utility and 70.0 visual analogue scale (VAS). Following SVR, a reduction occurred in the proportion of patients with mobility problems (35% vs 24%, p = 0.012), pain/discomfort (60% vs 42%, p<0.001) and anxiety/depression (57% vs 44%, p = 0.012), with an increase in utility (+0.053, p<0.001) and VAS (+10, p<0.001). Score improvements were also observed in cirrhotic (+0.048 utility, p = 0.027; +15 VAS, p<0.001) and HIV co-infected patients (+0.039 utility, p = 0.036; +5 VAS, p = 0.002). In multivariate analyses, middle age (45-64 years) and baseline anxiety/depression were associated to greater improvement in utility after SVR, and moderate-advanced liver fibrosis and cirrhosis to greater increase in VAS score. Low baseline values were associated to greater improvements in utility value and VAS score. CONCLUSIONS:The cure of chronic hepatitis C infection with DAA has a short term positive impact on HRQoL with improvement in mobility, pain/discomfort, anxiety/depression, utility value and VAS score. Patients with poor baseline HRQoL were the most beneficed. |
| first_indexed | 2024-12-11T23:35:43Z |
| format | Article |
| id | doaj.art-378f9fd242bf417ab7d4481be1f9ab08 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T23:35:43Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-378f9fd242bf417ab7d4481be1f9ab082022-12-22T00:45:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020527710.1371/journal.pone.0205277Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients.Regina JuanbeltzIván Martínez-BazRamón San MiguelSilvia Goñi-EsarteJuan Manuel CabasésJesús CastillaBACKGROUND:Direct-acting antivirals (DAA) have demonstrated high efficacy to achieve sustained virological response (SVR) in chronic hepatitis C patients. We aim to assess the change in health-related quality of life (HRQoL) among patients successfully treated, and to identify predictors of this variation. METHODS:In a prospective observational study, patients with chronic hepatitis C who started DAA therapy between May 2016 and April 2017 completed the EQ-5D-5L questionnaire at baseline and 12 weeks after the end of therapy before knowing the virological result. Analysis included all patients with SVR. RESULTS:Median baseline EQ-5D-5L scores of the 206 enrolled patients were 0.857 utility and 70.0 visual analogue scale (VAS). Following SVR, a reduction occurred in the proportion of patients with mobility problems (35% vs 24%, p = 0.012), pain/discomfort (60% vs 42%, p<0.001) and anxiety/depression (57% vs 44%, p = 0.012), with an increase in utility (+0.053, p<0.001) and VAS (+10, p<0.001). Score improvements were also observed in cirrhotic (+0.048 utility, p = 0.027; +15 VAS, p<0.001) and HIV co-infected patients (+0.039 utility, p = 0.036; +5 VAS, p = 0.002). In multivariate analyses, middle age (45-64 years) and baseline anxiety/depression were associated to greater improvement in utility after SVR, and moderate-advanced liver fibrosis and cirrhosis to greater increase in VAS score. Low baseline values were associated to greater improvements in utility value and VAS score. CONCLUSIONS:The cure of chronic hepatitis C infection with DAA has a short term positive impact on HRQoL with improvement in mobility, pain/discomfort, anxiety/depression, utility value and VAS score. Patients with poor baseline HRQoL were the most beneficed.http://europepmc.org/articles/PMC6177189?pdf=render |
| spellingShingle | Regina Juanbeltz Iván Martínez-Baz Ramón San Miguel Silvia Goñi-Esarte Juan Manuel Cabasés Jesús Castilla Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients. PLoS ONE |
| title | Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients. |
| title_full | Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients. |
| title_fullStr | Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients. |
| title_full_unstemmed | Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients. |
| title_short | Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients. |
| title_sort | impact of successful treatment with direct acting antiviral agents on health related quality of life in chronic hepatitis c patients |
| url | http://europepmc.org/articles/PMC6177189?pdf=render |
| work_keys_str_mv | AT reginajuanbeltz impactofsuccessfultreatmentwithdirectactingantiviralagentsonhealthrelatedqualityoflifeinchronichepatitiscpatients AT ivanmartinezbaz impactofsuccessfultreatmentwithdirectactingantiviralagentsonhealthrelatedqualityoflifeinchronichepatitiscpatients AT ramonsanmiguel impactofsuccessfultreatmentwithdirectactingantiviralagentsonhealthrelatedqualityoflifeinchronichepatitiscpatients AT silviagoniesarte impactofsuccessfultreatmentwithdirectactingantiviralagentsonhealthrelatedqualityoflifeinchronichepatitiscpatients AT juanmanuelcabases impactofsuccessfultreatmentwithdirectactingantiviralagentsonhealthrelatedqualityoflifeinchronichepatitiscpatients AT jesuscastilla impactofsuccessfultreatmentwithdirectactingantiviralagentsonhealthrelatedqualityoflifeinchronichepatitiscpatients |