PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

This study aimed to develop a physiologically based pharmacokinetic (PBPK) model that simulates metabolically cleared compounds’ pharmacokinetics (PK) in pregnant subjects and fetuses. This model accounts for the differences in tissue sizes, blood flow rates, enzyme expression levels, plasma protein...

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Bibliographic Details
Main Authors: Maxime Le Merdy, Ke Xu Szeto, Jeremy Perrier, Michael B. Bolger, Viera Lukacova
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceutics
Subjects:
PBPK
pregnancy
metabolic clearance
in silico
Online Access:https://www.mdpi.com/1999-4923/16/1/96

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