PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

This study aimed to develop a physiologically based pharmacokinetic (PBPK) model that simulates metabolically cleared compounds’ pharmacokinetics (PK) in pregnant subjects and fetuses. This model accounts for the differences in tissue sizes, blood flow rates, enzyme expression levels, plasma protein...

Podrobná bibliografie
Hlavní autoři:	Maxime Le Merdy, Ke Xu Szeto, Jeremy Perrier, Michael B. Bolger, Viera Lukacova
Médium:	Článek
Jazyk:	English
Vydáno:	MDPI AG 2024-01-01
Edice:	Pharmaceutics
Témata:	PBPK pregnancy metabolic clearance in silico
On-line přístup:	https://www.mdpi.com/1999-4923/16/1/96

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