Evaluation of Topical Mitomycin-C Eye Drops After Reconstructive Surgery for Anophthalmic Contracted Socket
Hala K Mattout, Sameh M Fouda, Haitham Y Al-Nashar‎Ophthalmology Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptCorrespondence: Hala K MattoutOphthalmology Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptEmail halamattout@gmail.com; HKMtoot@medicine.z...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-12-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/evaluation-of-topical-mitomycin-c-eye-drops-after-reconstructive-surge-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1818721183806259200 |
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| author | Mattout HK Fouda SM Al-Nashar HY |
| author_facet | Mattout HK Fouda SM Al-Nashar HY |
| author_sort | Mattout HK |
| collection | DOAJ |
| description | Hala K Mattout, Sameh M Fouda, Haitham Y Al-Nashar‎Ophthalmology Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptCorrespondence: Hala K MattoutOphthalmology Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptEmail halamattout@gmail.com; HKMtoot@medicine.zu.edu.egPurpose: To report the outcomes of using topical mitomycin-C (MMC) after reconstructive surgery for contracted socket and to compare the results with those of the conventional postoperative treatment.Patients and Methods: The medical records of patients who underwent reconstructive surgery for contracted anophthalmic socket were retrospectively reviewed. Based on the postoperative treatment protocol, two groups of patients were identified; group I (15 patients) who received topical MMC drops (0.02%) 4 times daily for 6 weeks and group II (15 patients) who received the conventional treatment (topical antibiotic-steroid combination). Preoperative data were extracted for age, gender, cause and timing of anophthalmia, history of previous surgeries, preoperative forniceal depth and socket volume (SV). The main postoperative outcome measures were superior fornix depth (SFD), inferior fornix depth (IFD) and SV at the end of 6th postoperative month. Prosthesis fitting and complications were also considered for analysis.Results: The mean preoperative IFD was 1.67± 0.04 mm in group I and 1.58± 0.37 mm in group II, by the end of the 6th postoperative month it increased to 6.1 ± 0.27 mm and 5.12 ± 0.25mm, respectively. The mean preoperative SFD in group I was 8.3± 0.9 mm and 8.9± 1.1 mm in group II, by the end of the 6th postoperative month SFD became 13.4± 1.2 mm and 10.2± 1.4 mm in groups I and II, respectively. The mean SV measured six months postoperatively was 1.9± 0.2 mL and 1.3± 0.09 mL in groups I and II, respectively. These differences in the postoperative SFD, IFD and SV between both groups were statistically significant. More cases reported successful fitting in group I than in group II but this difference was not statistically significant.Conclusion: Postoperative use of topical MMC is associated with higher forniceal depth and greater SV when compared to the conventional treatment in socket reconstructive surgeries with amniotic membrane graft (AMG).Keywords: contracted socket, mitomycin-C, amniotic membrane graft, anophthalmic socket, MMC, AMG |
| first_indexed | 2024-12-17T20:34:41Z |
| format | Article |
| id | doaj.art-3790d60596794193b99b60835cd9a482 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-17T20:34:41Z |
| publishDate | 2021-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-3790d60596794193b99b60835cd9a4822022-12-21T21:33:28ZengDove Medical PressClinical Ophthalmology1177-54832021-12-01Volume 154621462771269Evaluation of Topical Mitomycin-C Eye Drops After Reconstructive Surgery for Anophthalmic Contracted SocketMattout HKFouda SMAl-Nashar HYHala K Mattout, Sameh M Fouda, Haitham Y Al-Nashar‎Ophthalmology Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptCorrespondence: Hala K MattoutOphthalmology Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptEmail halamattout@gmail.com; HKMtoot@medicine.zu.edu.egPurpose: To report the outcomes of using topical mitomycin-C (MMC) after reconstructive surgery for contracted socket and to compare the results with those of the conventional postoperative treatment.Patients and Methods: The medical records of patients who underwent reconstructive surgery for contracted anophthalmic socket were retrospectively reviewed. Based on the postoperative treatment protocol, two groups of patients were identified; group I (15 patients) who received topical MMC drops (0.02%) 4 times daily for 6 weeks and group II (15 patients) who received the conventional treatment (topical antibiotic-steroid combination). Preoperative data were extracted for age, gender, cause and timing of anophthalmia, history of previous surgeries, preoperative forniceal depth and socket volume (SV). The main postoperative outcome measures were superior fornix depth (SFD), inferior fornix depth (IFD) and SV at the end of 6th postoperative month. Prosthesis fitting and complications were also considered for analysis.Results: The mean preoperative IFD was 1.67± 0.04 mm in group I and 1.58± 0.37 mm in group II, by the end of the 6th postoperative month it increased to 6.1 ± 0.27 mm and 5.12 ± 0.25mm, respectively. The mean preoperative SFD in group I was 8.3± 0.9 mm and 8.9± 1.1 mm in group II, by the end of the 6th postoperative month SFD became 13.4± 1.2 mm and 10.2± 1.4 mm in groups I and II, respectively. The mean SV measured six months postoperatively was 1.9± 0.2 mL and 1.3± 0.09 mL in groups I and II, respectively. These differences in the postoperative SFD, IFD and SV between both groups were statistically significant. More cases reported successful fitting in group I than in group II but this difference was not statistically significant.Conclusion: Postoperative use of topical MMC is associated with higher forniceal depth and greater SV when compared to the conventional treatment in socket reconstructive surgeries with amniotic membrane graft (AMG).Keywords: contracted socket, mitomycin-C, amniotic membrane graft, anophthalmic socket, MMC, AMGhttps://www.dovepress.com/evaluation-of-topical-mitomycin-c-eye-drops-after-reconstructive-surge-peer-reviewed-fulltext-article-OPTHcontracted socketmitomycin camniotic membrane graftanophthalmic socket |
| spellingShingle | Mattout HK Fouda SM Al-Nashar HY Evaluation of Topical Mitomycin-C Eye Drops After Reconstructive Surgery for Anophthalmic Contracted Socket Clinical Ophthalmology contracted socket mitomycin c amniotic membrane graft anophthalmic socket |
| title | Evaluation of Topical Mitomycin-C Eye Drops After Reconstructive Surgery for Anophthalmic Contracted Socket |
| title_full | Evaluation of Topical Mitomycin-C Eye Drops After Reconstructive Surgery for Anophthalmic Contracted Socket |
| title_fullStr | Evaluation of Topical Mitomycin-C Eye Drops After Reconstructive Surgery for Anophthalmic Contracted Socket |
| title_full_unstemmed | Evaluation of Topical Mitomycin-C Eye Drops After Reconstructive Surgery for Anophthalmic Contracted Socket |
| title_short | Evaluation of Topical Mitomycin-C Eye Drops After Reconstructive Surgery for Anophthalmic Contracted Socket |
| title_sort | evaluation of topical mitomycin c eye drops after reconstructive surgery for anophthalmic contracted socket |
| topic | contracted socket mitomycin c amniotic membrane graft anophthalmic socket |
| url | https://www.dovepress.com/evaluation-of-topical-mitomycin-c-eye-drops-after-reconstructive-surge-peer-reviewed-fulltext-article-OPTH |
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