Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni

Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni

AbstractSchistosoma mansoni is an intestinal parasite with one β-class carbonic anhydrase, SmaBCA. We report the sequence enhancing, production, catalytic activity, and inhibition results of the recombinant SmaBCA. It showed significant catalytic activity on CO2 hydration in vitro with kcat 1.38 × 1...

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Bibliographic Details
Main Authors: Susanna Haapanen, Andrea Angeli, Martti Tolvanen, Reza Zolfaghari Emameh, Claudiu T. Supuran, Seppo Parkkila
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Carbonic anhydrase
anti-parasitic agents
inhibitor
sulphonamide
Schistosoma mansoni
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2184299

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https://www.tandfonline.com/doi/10.1080/14756366.2023.2184299

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