The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review
In both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction and cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. However, the physiological differences between humans and common...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/11/3406 |
| _version_ | 1797531366137528320 |
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| author | Benjamin Zimmerman Payel Kundu William D. Rooney Jacob Raber |
| author_facet | Benjamin Zimmerman Payel Kundu William D. Rooney Jacob Raber |
| author_sort | Benjamin Zimmerman |
| collection | DOAJ |
| description | In both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction and cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. However, the physiological differences between humans and common animal models in terms of how they react metabolically to high-fat diets need to be considered. Here, we review the factors that may affect the translatability of mechanistic research in animal models, paying special attention to the effects of a high-fat diet on vascular outcomes. We draw attention to the dissociation between metabolic syndrome and dyslipidemia in rodents, unlike the state in humans, where the two commonly occur. We also discuss the differential vulnerability between species to the metabolic and vascular effects of macronutrients in the diet. Findings from animal studies are better interpreted as modeling specific aspects of dysfunction. We conclude that the differences between species provide an opportunity to explore why some species are protected from the detrimental aspects of high-fat-diet-induced dysfunction, and to translate these findings into benefits for human health. |
| first_indexed | 2024-03-10T10:42:45Z |
| format | Article |
| id | doaj.art-37916513bc844d0abf447fec7d6d2866 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:42:45Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-37916513bc844d0abf447fec7d6d28662023-11-21T22:49:17ZengMDPI AGMolecules1420-30492021-06-012611340610.3390/molecules26113406The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative ReviewBenjamin Zimmerman0Payel Kundu1William D. Rooney2Jacob Raber3Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USADepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USADepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USADepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USAIn both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction and cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. However, the physiological differences between humans and common animal models in terms of how they react metabolically to high-fat diets need to be considered. Here, we review the factors that may affect the translatability of mechanistic research in animal models, paying special attention to the effects of a high-fat diet on vascular outcomes. We draw attention to the dissociation between metabolic syndrome and dyslipidemia in rodents, unlike the state in humans, where the two commonly occur. We also discuss the differential vulnerability between species to the metabolic and vascular effects of macronutrients in the diet. Findings from animal studies are better interpreted as modeling specific aspects of dysfunction. We conclude that the differences between species provide an opportunity to explore why some species are protected from the detrimental aspects of high-fat-diet-induced dysfunction, and to translate these findings into benefits for human health.https://www.mdpi.com/1420-3049/26/11/3406high-fat dietspecies differencescardiovascular healthmetabolismcerebrovasculaturecognition |
| spellingShingle | Benjamin Zimmerman Payel Kundu William D. Rooney Jacob Raber The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review Molecules high-fat diet species differences cardiovascular health metabolism cerebrovasculature cognition |
| title | The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review |
| title_full | The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review |
| title_fullStr | The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review |
| title_full_unstemmed | The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review |
| title_short | The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review |
| title_sort | effect of high fat diet on cerebrovascular health and pathology a species comparative review |
| topic | high-fat diet species differences cardiovascular health metabolism cerebrovasculature cognition |
| url | https://www.mdpi.com/1420-3049/26/11/3406 |
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