The role of Drosophila antifungal immune response genes in intestinal homeostasis
The signaling pathways that control intestinal development, regeneration and disease show a high degree of conservation between Drosophila and mammals. The gut epithelia of Drosophila provide protection against invasion of microorganisms through production of reactive oxygen species (ROS) and anti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2015-08-01
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| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | http://www.degruyter.com/view/j/biol.2015.10.issue-1/biol-2015-0041/biol-2015-0041.xml?format=INT |
| _version_ | 1818525957512757248 |
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| author | Hao Yangguang Liu Qiang Jin Li Hua |
| author_facet | Hao Yangguang Liu Qiang Jin Li Hua |
| author_sort | Hao Yangguang |
| collection | DOAJ |
| description | The signaling pathways that control intestinal
development, regeneration and disease show a high
degree of conservation between Drosophila and mammals.
The gut epithelia of Drosophila provide protection against
invasion of microorganisms through production of reactive
oxygen species (ROS) and antimicrobial peptides (AMPs).
Although Drosophila gut immunity has been extensively
studied, the specific responses to Gram-positive bacteria,
fungi and toxic compounds are not fully understood. To
identify the physiological role of genes involved in host
defense we studied Drosophila mutants in antifungal
genes identified previously and tested their survival upon
feeding with various pathogens and toxic compounds.
The results showed that several mutants displayed
decreased viability compared with wild-type flies, and
the lower survival rates were attributed to morphological
change and excessive cell death in mutant guts. Thus, we
identified several new Drosophila genes (spen, jumeau,
inv, DDB1 and shg) required for intestinal homeostasis or
stress responses. |
| first_indexed | 2024-12-11T06:16:18Z |
| format | Article |
| id | doaj.art-379247b90af141059fbe544589f5585a |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-12-11T06:16:18Z |
| publishDate | 2015-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-379247b90af141059fbe544589f5585a2022-12-22T01:17:57ZengDe GruyterOpen Life Sciences2391-54122015-08-0110110.1515/biol-2015-0041biol-2015-0041The role of Drosophila antifungal immune response genes in intestinal homeostasisHao Yangguang0Liu Qiang1Jin Li Hua2College of Life Sciences, Northeast Forestry University, Harbin, 150040, ChinaCollege of Life Sciences, Northeast Forestry University, Harbin, 150040, ChinaCollege of Life Sciences, Northeast Forestry University, Harbin, 150040, ChinaThe signaling pathways that control intestinal development, regeneration and disease show a high degree of conservation between Drosophila and mammals. The gut epithelia of Drosophila provide protection against invasion of microorganisms through production of reactive oxygen species (ROS) and antimicrobial peptides (AMPs). Although Drosophila gut immunity has been extensively studied, the specific responses to Gram-positive bacteria, fungi and toxic compounds are not fully understood. To identify the physiological role of genes involved in host defense we studied Drosophila mutants in antifungal genes identified previously and tested their survival upon feeding with various pathogens and toxic compounds. The results showed that several mutants displayed decreased viability compared with wild-type flies, and the lower survival rates were attributed to morphological change and excessive cell death in mutant guts. Thus, we identified several new Drosophila genes (spen, jumeau, inv, DDB1 and shg) required for intestinal homeostasis or stress responses.http://www.degruyter.com/view/j/biol.2015.10.issue-1/biol-2015-0041/biol-2015-0041.xml?format=INTDrosophila intestinal homeostasis antifungal genes ingestion stress response |
| spellingShingle | Hao Yangguang Liu Qiang Jin Li Hua The role of Drosophila antifungal immune response genes in intestinal homeostasis Open Life Sciences Drosophila intestinal homeostasis antifungal genes ingestion stress response |
| title | The role of Drosophila antifungal immune response genes in intestinal homeostasis |
| title_full | The role of Drosophila antifungal immune response genes in intestinal homeostasis |
| title_fullStr | The role of Drosophila antifungal immune response genes in intestinal homeostasis |
| title_full_unstemmed | The role of Drosophila antifungal immune response genes in intestinal homeostasis |
| title_short | The role of Drosophila antifungal immune response genes in intestinal homeostasis |
| title_sort | role of drosophila antifungal immune response genes in intestinal homeostasis |
| topic | Drosophila intestinal homeostasis antifungal genes ingestion stress response |
| url | http://www.degruyter.com/view/j/biol.2015.10.issue-1/biol-2015-0041/biol-2015-0041.xml?format=INT |
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