Nitric oxide hinders club cell proliferation through Gdpd2 during allergic airway inflammation
Excessive nitric oxide (NO) is often observed in the airways of patients with severe asthma. Here, we show that the NO donor diethylamine NONOate impairs the proliferative capacity of mouse club cells and induces club cell apoptosis, cell cycle arrest, and alterations in lipid metabolism. Our data s...
Main Authors: | Qing Yue, Kuan Li, Zhaoyu Song, Qi Wang, Jianhai Wang, Xue Li, Yu Li, Qiuyang Zhang, Yu Zhu, Huaiyong Chen |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2023-06-01
|
Series: | FEBS Open Bio |
Subjects: | |
Online Access: | https://doi.org/10.1002/2211-5463.13617 |
Similar Items
-
Glycerol : The Renewable Platform Chemical /
by: Pagliaro, Mario, 1969-, author
Published: (2017) -
The future of glycerol : new uses of a versatile raw material /
by: Pagliaro, Mario, 1969-, et al.
Published: (2008) -
Niche-Dependent Regulation of Lkb1 in the Proliferation of Lung Epithelial Progenitor Cells
by: Qingwen Ma, et al.
Published: (2022-12-01) -
Nitric oxide synthase inhibitor reduces airway inflammation in mouse models with asthma
by: WANG Fei, LI Wenxuan, DING Junqiong, LIU Zhen, WANG Xiaoming, YANG Ju, WANG Dalian
Published: (2023-03-01) -
Glycerin (pharmaceutical grade)
by: 982 SIRIM