Features of prediabetes management in adolescents with excessive body weight and obesity
Background. Type 2 diabetes mellitus (T2DM) in childhood and adolescence is a relatively new disease. Until 1980, type 1 diabetes was considered the only form of diabetes in children and adolescents. Currently, the number of children suffering from type 2 diabetes is increasing annually worldwide. A...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2022-12-01
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| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
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| Online Access: | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1222 |
| Summary: | Background. Type 2 diabetes mellitus (T2DM) in childhood and adolescence is a relatively new disease. Until 1980, type 1 diabetes was considered the only form of diabetes in children and adolescents. Currently, the number of children suffering from type 2 diabetes is increasing annually worldwide. An increase in the number of adolescents with T2DM against the backdrop of overweight and obesity has also been recorded in Ukraine. The purpose of the study was to evaluate the effectiveness and safety of the dietary supplement Sakhnil as an additional complex of biologically active substances of plant origin in adolescents with impaired carbohydrate metabolism in the presence of overweight and obesity. Materials and methods. Eighteen adolescents with impaired glucose tolerance (IGT) against the background of overweight and obesity were under observation. The control group consisted of 20 obese adolescents without carbohydrate metabolism disorders. For patients with IGT, the criteria for inclusion in the study were: age of 15–18 years at the time of diagnosis, presence of hyperinsulinemia and insulin resistance (according to the Homeostatic Model Assessment for Insulin Resistance (HOMA)), overweight and obesity. Exclusion criteria were: type 1 diabetes and monogenic forms of diabetes, presence of ketonuria. Results. In the first and second groups, by the end of observation, there was no significant decrease in fasting glycemia, HbA1c level, as these indicators were within the reference values. However, at the end of the treatment, the first group with IGT showed a significant decrease in the level of glycemia 2 hours after the load. Therapy with the dietary supplement Sakhnil led to a significant decrease (by 23.1 %, p = 0.01) in glycemia 2 hours after the load, which was 7.06 ± 0.18 mmol/l. The difference between groups reached high reliability (p = 0.01). In the process of observation and treatment, there was a tendency to decrease the level of immunoreactive insulin (from 19.3 ± 3.1 μU/ml to 16.2 ± 2.7) and the value of the HOMA (from 3.1 ± 0.4 to 2.7 ± 0.4) in adolescents with IGT on the background of overweight and obesity. Conclusions. Dietary supplement Sakhnil is an effective remedy for the treatment of adolescents with impaired glucose tolerance. Sakhnil is well tolerated by patients, does not cause side effects. |
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| ISSN: | 2224-0721 2307-1427 |