Effect of dexpanthenol on wound healing in penile fracture model: An experimental study
Objectives: In the present study, we aimed to investigate the effect of dexpanthenol on wound healing at the histopathological level on cavernous tissue. Materials and methods: Forty-four Wistar albino rats weighing 220-250 g were used. The rats were randomly divided into four groups as Group B, Gro...
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2022-01-01
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| Series: | Cirugía y Cirujanos |
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| author | Veli M. Yazar Omer G. Doluoglu Berat C. Ozgur Muzaffer Çaydere Turgay Akgul Engin Dogantekin Sema Hücümenoglu Koray Agras |
| author_facet | Veli M. Yazar Omer G. Doluoglu Berat C. Ozgur Muzaffer Çaydere Turgay Akgul Engin Dogantekin Sema Hücümenoglu Koray Agras |
| author_sort | Veli M. Yazar |
| collection | DOAJ |
| description | Objectives: In the present study, we aimed to investigate the effect of dexpanthenol on wound healing at the histopathological level on cavernous tissue. Materials and methods: Forty-four Wistar albino rats weighing 220-250 g were used. The rats were randomly divided into four groups as Group B, Group S, Group LD, and Group SD. In Group B, the incision was not repaired and left to secondary healing. In Group S, the incision line was repaired with 5/0 polyglactin suture. In Group LD, 0.25 mg/kg dexpanthenol was applied subcutaneously below the repaired wound region once a day during 14 days. In Group SD, 500 mg dexpanthenol was applied intraperitoneally once a day during 14 days. Results: No fibrosis was observed in 8 (80%) rats in group SD. Fibrosis rates were significantly lower in Group SD compared to Group B, Group S, and Group LD (p = 0.013, p = 0.005, and p = 0.003, respectively). Conclusion: Systemic dexpanthenol administration significantly decreased fibrosis in penile fracture model on rats.
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| first_indexed | 2024-04-11T14:53:43Z |
| format | Article |
| id | doaj.art-3794508fbd6c4030a145ed6fd5881a7e |
| institution | Directory Open Access Journal |
| issn | 2444-054X |
| language | English |
| last_indexed | 2024-04-11T14:53:43Z |
| publishDate | 2022-01-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Cirugía y Cirujanos |
| spelling | doaj.art-3794508fbd6c4030a145ed6fd5881a7e2022-12-22T04:17:19ZengPermanyerCirugía y Cirujanos2444-054X2022-01-01909210.24875/CIRU.22000100Effect of dexpanthenol on wound healing in penile fracture model: An experimental studyVeli M. Yazar0Omer G. Doluoglu1Berat C. Ozgur2Muzaffer Çaydere3Turgay Akgul4Engin Dogantekin5Sema Hücümenoglu6Koray Agras7Department of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, TurkeyDepartment of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, TurkeyDepartment of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, TurkeyDepartment of Pathology. Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, TurkeyDepartment of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, TurkeyDepartment of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, TurkeyDepartment of Pathology. Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, TurkeyDepartment of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, TurkeyObjectives: In the present study, we aimed to investigate the effect of dexpanthenol on wound healing at the histopathological level on cavernous tissue. Materials and methods: Forty-four Wistar albino rats weighing 220-250 g were used. The rats were randomly divided into four groups as Group B, Group S, Group LD, and Group SD. In Group B, the incision was not repaired and left to secondary healing. In Group S, the incision line was repaired with 5/0 polyglactin suture. In Group LD, 0.25 mg/kg dexpanthenol was applied subcutaneously below the repaired wound region once a day during 14 days. In Group SD, 500 mg dexpanthenol was applied intraperitoneally once a day during 14 days. Results: No fibrosis was observed in 8 (80%) rats in group SD. Fibrosis rates were significantly lower in Group SD compared to Group B, Group S, and Group LD (p = 0.013, p = 0.005, and p = 0.003, respectively). Conclusion: Systemic dexpanthenol administration significantly decreased fibrosis in penile fracture model on rats. https://www.cirugiaycirujanos.com/frame_esp.php?id=779Dexpanthenol. Fibrosis. Penile fracture. Rat. |
| spellingShingle | Veli M. Yazar Omer G. Doluoglu Berat C. Ozgur Muzaffer Çaydere Turgay Akgul Engin Dogantekin Sema Hücümenoglu Koray Agras Effect of dexpanthenol on wound healing in penile fracture model: An experimental study Cirugía y Cirujanos Dexpanthenol. Fibrosis. Penile fracture. Rat. |
| title | Effect of dexpanthenol on wound healing in penile fracture model: An experimental study |
| title_full | Effect of dexpanthenol on wound healing in penile fracture model: An experimental study |
| title_fullStr | Effect of dexpanthenol on wound healing in penile fracture model: An experimental study |
| title_full_unstemmed | Effect of dexpanthenol on wound healing in penile fracture model: An experimental study |
| title_short | Effect of dexpanthenol on wound healing in penile fracture model: An experimental study |
| title_sort | effect of dexpanthenol on wound healing in penile fracture model an experimental study |
| topic | Dexpanthenol. Fibrosis. Penile fracture. Rat. |
| url | https://www.cirugiaycirujanos.com/frame_esp.php?id=779 |
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