A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders
RationaleChildhood maltreatment (CM) leads to detrimental mental health outcomes, such as substance use disorders (SUD). This study examined prevalence and severity of all five types of CM with respect to specific substances and sex in treatment-seeking individuals with SUD. The influences of type o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.866019/full |
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| author | Sarah Gerhardt Katharina Eidenmueller Sabine Hoffmann Sabine Hoffmann Nina K. Bekier Patrick Bach Derik Hermann Derik Hermann Anne Koopmann Wolfgang H. Sommer Wolfgang H. Sommer Wolfgang H. Sommer Falk Kiefer Falk Kiefer Falk Kiefer Sabine Vollstädt-Klein Sabine Vollstädt-Klein |
| author_facet | Sarah Gerhardt Katharina Eidenmueller Sabine Hoffmann Sabine Hoffmann Nina K. Bekier Patrick Bach Derik Hermann Derik Hermann Anne Koopmann Wolfgang H. Sommer Wolfgang H. Sommer Wolfgang H. Sommer Falk Kiefer Falk Kiefer Falk Kiefer Sabine Vollstädt-Klein Sabine Vollstädt-Klein |
| author_sort | Sarah Gerhardt |
| collection | DOAJ |
| description | RationaleChildhood maltreatment (CM) leads to detrimental mental health outcomes, such as substance use disorders (SUD). This study examined prevalence and severity of all five types of CM with respect to specific substances and sex in treatment-seeking individuals with SUD. The influences of type of CM and symptoms of depressiveness, anxiety, and perceived stress on substance craving at admission as well as craving reduction during SUD treatment were examined.MethodsN = 546 patients in treatment for SUD and N = 109 individuals in opioid maintenance treatment filled out questionnaires regarding CM (Childhood Trauma Questionnaire) and psychopathologies. Substance craving was assessed throughout treatment using the Mannheim Craving Scale. Group differences in CM, type of substance and sex were examined. General linear models were applied to examine influences on substance craving.ResultsHigher prevalence and severity of all five subtypes of CM were observed in individuals with SUD compared to the general population. Women were more severely affected by emotional and sexual abuse than men. Patients with cannabis use disorder reported more severe experiences of emotional abuse compared to all other substances. Craving at admission to treatment was influenced by emotional abuse, however, symptoms of depressiveness, anxiety, and perceived stress contributed to craving at admission or craving reduction during treatment.ConclusionCM relates to SUD and should be incorporated in prevention and treatment of SUD. Underlying mechanisms of the association might relate to impairments in processing and regulation of stress, emotions, and interpersonal relations following a history of CM. |
| first_indexed | 2024-04-13T17:20:15Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-13T17:20:15Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-379604f2027a4fb990cd13eb8c6dde262022-12-22T02:38:00ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-04-011310.3389/fpsyt.2022.866019866019A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use DisordersSarah Gerhardt0Katharina Eidenmueller1Sabine Hoffmann2Sabine Hoffmann3Nina K. Bekier4Patrick Bach5Derik Hermann6Derik Hermann7Anne Koopmann8Wolfgang H. Sommer9Wolfgang H. Sommer10Wolfgang H. Sommer11Falk Kiefer12Falk Kiefer13Falk Kiefer14Sabine Vollstädt-Klein15Sabine Vollstädt-Klein16Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Biostatistics, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyTherapieverbund Ludwigsmühle gGmbH, Landau, GermanyDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyInstitute for Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyBethania Hospital for Psychiatry, Psychosomatics, and Psychotherapy, Greifswald, GermanyDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyMannheim Center of Translational Neurosciences, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyFeuerlein Center on Translational Addiction Medicine, Heidelberg University, Heidelberg, GermanyDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyMannheim Center of Translational Neurosciences, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyRationaleChildhood maltreatment (CM) leads to detrimental mental health outcomes, such as substance use disorders (SUD). This study examined prevalence and severity of all five types of CM with respect to specific substances and sex in treatment-seeking individuals with SUD. The influences of type of CM and symptoms of depressiveness, anxiety, and perceived stress on substance craving at admission as well as craving reduction during SUD treatment were examined.MethodsN = 546 patients in treatment for SUD and N = 109 individuals in opioid maintenance treatment filled out questionnaires regarding CM (Childhood Trauma Questionnaire) and psychopathologies. Substance craving was assessed throughout treatment using the Mannheim Craving Scale. Group differences in CM, type of substance and sex were examined. General linear models were applied to examine influences on substance craving.ResultsHigher prevalence and severity of all five subtypes of CM were observed in individuals with SUD compared to the general population. Women were more severely affected by emotional and sexual abuse than men. Patients with cannabis use disorder reported more severe experiences of emotional abuse compared to all other substances. Craving at admission to treatment was influenced by emotional abuse, however, symptoms of depressiveness, anxiety, and perceived stress contributed to craving at admission or craving reduction during treatment.ConclusionCM relates to SUD and should be incorporated in prevention and treatment of SUD. Underlying mechanisms of the association might relate to impairments in processing and regulation of stress, emotions, and interpersonal relations following a history of CM.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.866019/fullchildhood traumaaddictionsex differencessubstance cravingsubstance use disorderperceived stress |
| spellingShingle | Sarah Gerhardt Katharina Eidenmueller Sabine Hoffmann Sabine Hoffmann Nina K. Bekier Patrick Bach Derik Hermann Derik Hermann Anne Koopmann Wolfgang H. Sommer Wolfgang H. Sommer Wolfgang H. Sommer Falk Kiefer Falk Kiefer Falk Kiefer Sabine Vollstädt-Klein Sabine Vollstädt-Klein A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders Frontiers in Psychiatry childhood trauma addiction sex differences substance craving substance use disorder perceived stress |
| title | A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders |
| title_full | A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders |
| title_fullStr | A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders |
| title_full_unstemmed | A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders |
| title_short | A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders |
| title_sort | history of childhood maltreatment has substance and sex specific effects on craving during treatment for substance use disorders |
| topic | childhood trauma addiction sex differences substance craving substance use disorder perceived stress |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.866019/full |
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