Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study
Abstract Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment....
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-07-01
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| Series: | World Journal of Emergency Surgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13017-019-0253-2 |
| _version_ | 1818682251597053952 |
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| author | Massimo Sartelli Fikri M. Abu-Zidan Francesco M. Labricciosa Yoram Kluger Federico Coccolini Luca Ansaloni Ari Leppäniemi Andrew W. Kirkpatrick Matti Tolonen Cristian Tranà Jean-Marc Regimbeau Timothy Hardcastle Renol M. Koshy Ashraf Abbas Ulaş Aday A. R. K. Adesunkanmi Adesina Ajibade Lali Akhmeteli Emrah Akın Nezih Akkapulu Alhenouf Alotaibi Fatih Altintoprak Dimitrios Anyfantakis Boyko Atanasov Goran Augustin Constança Azevedo Miklosh Bala Dimitrios Balalis Oussama Baraket Suman Baral Or Barkai Marcelo Beltran Roberto Bini Konstantinos Bouliaris Ana B. Caballero Valentin Calu Marco Catani Marco Ceresoli Vasileios Charalampakis Asri Che Jusoh Massimo Chiarugi Nicola Cillara Raquel Cobos Cuesta Luigi Cobuccio Gianfranco Cocorullo Elif Colak Luigi Conti Yunfeng Cui Belinda De Simone Samir Delibegovic Zaza Demetrashvili Demetrios Demetriades Ana Dimova Agron Dogjani Mushira Enani Federica Farina Francesco Ferrara Domitilla Foghetti Tommaso Fontana Gustavo P. Fraga Mahir Gachabayov Grelpois Gérard Wagih Ghnnam Teresa Giménez Maurel Georgios Gkiokas Carlos A. Gomes Ali Guner Sanjay Gupta Andreas Hecker Elcio S. Hirano Adrien Hodonou Martin Hutan Igor Ilaschuk Orestis Ioannidis Arda Isik Georgy Ivakhov Sumita Jain Mantas Jokubauskas Aleksandar Karamarkovic Robin Kaushik Jakub Kenig Vladimir Khokha Denis Khokha Jae Il Kim Victor Kong Dimitris Korkolis Vitor F. Kruger Ashok Kshirsagar Romeo Lages Simões Andrea Lanaia Konstantinos Lasithiotakis Pedro Leão Miguel León Arellano Holger Listle Andrey Litvin Aintzane Lizarazu Pérez Eudaldo Lopez-Tomassetti Fernandez Eftychios Lostoridis Davide Luppi Gustavo M. Machain V Piotr Major Dimitrios Manatakis Marianne Marchini Reitz Athanasios Marinis Daniele Marrelli Aleix Martínez-Pérez Sanjay Marwah Michael McFarlane Mirza Mesic Cristian Mesina Nickos Michalopoulos Evangelos Misiakos Felipe Gonçalves Moreira Ouadii Mouaqit Ali Muhtaroglu Noel Naidoo Ionut Negoi Zane Nikitina Ioannis Nikolopoulos Gabriela-Elisa Nita Savino Occhionorelli Iyiade Olaoye Carlos A. Ordoñez Zeynep Ozkan Ajay Pal Gian M. Palini Kyriaki Papageorgiou Dimitris Papagoras Francesco Pata Michał Pędziwiatr Jorge Pereira Gerson A. Pereira Junior Gennaro Perrone Tadeja Pintar Magdalena Pisarska Oleksandr Plehutsa Mauro Podda Gaetano Poillucci Martha Quiodettis Tuba Rahim Daniel Rios-Cruz Gabriel Rodrigues Dmytry Rozov Boris Sakakushev Ibrahima Sall Alexander Sazhin Miguel Semião Taanya Sharda Vishal Shelat Giovanni Sinibaldi Dmitrijs Skicko Matej Skrovina Dimitrios Stamatiou Marco Stella Marcin Strzałka Ruslan Sydorchuk Ricardo A. Teixeira Gonsaga Joel Noutakdie Tochie Gia Tomadze Lara Ugoletti Jan Ulrych Toomas Ümarik Mustafa Y. Uzunoglu Alin Vasilescu Osborne Vaz Andras Vereczkei Nutu Vlad Maciej Walędziak Ali I. Yahya Omer Yalkin Tonguç U. Yilmaz Ali Ekrem Ünal Kuo-Ching Yuan Sanoop K. Zachariah Justas Žilinskas Maurizio Zizzo Vittoria Pattonieri Gian Luca Baiocchi Fausto Catena |
| author_facet | Massimo Sartelli Fikri M. Abu-Zidan Francesco M. Labricciosa Yoram Kluger Federico Coccolini Luca Ansaloni Ari Leppäniemi Andrew W. Kirkpatrick Matti Tolonen Cristian Tranà Jean-Marc Regimbeau Timothy Hardcastle Renol M. Koshy Ashraf Abbas Ulaş Aday A. R. K. Adesunkanmi Adesina Ajibade Lali Akhmeteli Emrah Akın Nezih Akkapulu Alhenouf Alotaibi Fatih Altintoprak Dimitrios Anyfantakis Boyko Atanasov Goran Augustin Constança Azevedo Miklosh Bala Dimitrios Balalis Oussama Baraket Suman Baral Or Barkai Marcelo Beltran Roberto Bini Konstantinos Bouliaris Ana B. Caballero Valentin Calu Marco Catani Marco Ceresoli Vasileios Charalampakis Asri Che Jusoh Massimo Chiarugi Nicola Cillara Raquel Cobos Cuesta Luigi Cobuccio Gianfranco Cocorullo Elif Colak Luigi Conti Yunfeng Cui Belinda De Simone Samir Delibegovic Zaza Demetrashvili Demetrios Demetriades Ana Dimova Agron Dogjani Mushira Enani Federica Farina Francesco Ferrara Domitilla Foghetti Tommaso Fontana Gustavo P. Fraga Mahir Gachabayov Grelpois Gérard Wagih Ghnnam Teresa Giménez Maurel Georgios Gkiokas Carlos A. Gomes Ali Guner Sanjay Gupta Andreas Hecker Elcio S. Hirano Adrien Hodonou Martin Hutan Igor Ilaschuk Orestis Ioannidis Arda Isik Georgy Ivakhov Sumita Jain Mantas Jokubauskas Aleksandar Karamarkovic Robin Kaushik Jakub Kenig Vladimir Khokha Denis Khokha Jae Il Kim Victor Kong Dimitris Korkolis Vitor F. Kruger Ashok Kshirsagar Romeo Lages Simões Andrea Lanaia Konstantinos Lasithiotakis Pedro Leão Miguel León Arellano Holger Listle Andrey Litvin Aintzane Lizarazu Pérez Eudaldo Lopez-Tomassetti Fernandez Eftychios Lostoridis Davide Luppi Gustavo M. Machain V Piotr Major Dimitrios Manatakis Marianne Marchini Reitz Athanasios Marinis Daniele Marrelli Aleix Martínez-Pérez Sanjay Marwah Michael McFarlane Mirza Mesic Cristian Mesina Nickos Michalopoulos Evangelos Misiakos Felipe Gonçalves Moreira Ouadii Mouaqit Ali Muhtaroglu Noel Naidoo Ionut Negoi Zane Nikitina Ioannis Nikolopoulos Gabriela-Elisa Nita Savino Occhionorelli Iyiade Olaoye Carlos A. Ordoñez Zeynep Ozkan Ajay Pal Gian M. Palini Kyriaki Papageorgiou Dimitris Papagoras Francesco Pata Michał Pędziwiatr Jorge Pereira Gerson A. Pereira Junior Gennaro Perrone Tadeja Pintar Magdalena Pisarska Oleksandr Plehutsa Mauro Podda Gaetano Poillucci Martha Quiodettis Tuba Rahim Daniel Rios-Cruz Gabriel Rodrigues Dmytry Rozov Boris Sakakushev Ibrahima Sall Alexander Sazhin Miguel Semião Taanya Sharda Vishal Shelat Giovanni Sinibaldi Dmitrijs Skicko Matej Skrovina Dimitrios Stamatiou Marco Stella Marcin Strzałka Ruslan Sydorchuk Ricardo A. Teixeira Gonsaga Joel Noutakdie Tochie Gia Tomadze Lara Ugoletti Jan Ulrych Toomas Ümarik Mustafa Y. Uzunoglu Alin Vasilescu Osborne Vaz Andras Vereczkei Nutu Vlad Maciej Walędziak Ali I. Yahya Omer Yalkin Tonguç U. Yilmaz Ali Ekrem Ünal Kuo-Ching Yuan Sanoop K. Zachariah Justas Žilinskas Maurizio Zizzo Vittoria Pattonieri Gian Luca Baiocchi Fausto Catena |
| author_sort | Massimo Sartelli |
| collection | DOAJ |
| description | Abstract Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28–66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4–10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0–1, 22.7% for those who had scores of 2–3, 46.8% for those who had scores of 4–5, and 86.7% for those who have scores of 7–8. Conclusions The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality. |
| first_indexed | 2024-12-17T10:15:53Z |
| format | Article |
| id | doaj.art-3796a866967c4cd184a7bd24d4b702f5 |
| institution | Directory Open Access Journal |
| issn | 1749-7922 |
| language | English |
| last_indexed | 2024-12-17T10:15:53Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Emergency Surgery |
| spelling | doaj.art-3796a866967c4cd184a7bd24d4b702f52022-12-21T21:52:55ZengBMCWorld Journal of Emergency Surgery1749-79222019-07-0114111110.1186/s13017-019-0253-2Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational studyMassimo Sartelli0Fikri M. Abu-Zidan1Francesco M. Labricciosa2Yoram Kluger3Federico Coccolini4Luca Ansaloni5Ari Leppäniemi6Andrew W. Kirkpatrick7Matti Tolonen8Cristian Tranà9Jean-Marc Regimbeau10Timothy Hardcastle11Renol M. Koshy12Ashraf Abbas13Ulaş Aday14A. R. K. Adesunkanmi15Adesina Ajibade16Lali Akhmeteli17Emrah Akın18Nezih Akkapulu19Alhenouf Alotaibi20Fatih Altintoprak21Dimitrios Anyfantakis22Boyko Atanasov23Goran Augustin24Constança Azevedo25Miklosh Bala26Dimitrios Balalis27Oussama Baraket28Suman Baral29Or Barkai30Marcelo Beltran31Roberto Bini32Konstantinos Bouliaris33Ana B. Caballero34Valentin Calu35Marco Catani36Marco Ceresoli37Vasileios Charalampakis38Asri Che Jusoh39Massimo Chiarugi40Nicola Cillara41Raquel Cobos Cuesta42Luigi Cobuccio43Gianfranco Cocorullo44Elif Colak45Luigi Conti46Yunfeng Cui47Belinda De Simone48Samir Delibegovic49Zaza Demetrashvili50Demetrios Demetriades51Ana Dimova52Agron Dogjani53Mushira Enani54Federica Farina55Francesco Ferrara56Domitilla Foghetti57Tommaso Fontana58Gustavo P. Fraga59Mahir Gachabayov60Grelpois Gérard61Wagih Ghnnam62Teresa Giménez Maurel63Georgios Gkiokas64Carlos A. Gomes65Ali Guner66Sanjay Gupta67Andreas Hecker68Elcio S. Hirano69Adrien Hodonou70Martin Hutan71Igor Ilaschuk72Orestis Ioannidis73Arda Isik74Georgy Ivakhov75Sumita Jain76Mantas Jokubauskas77Aleksandar Karamarkovic78Robin Kaushik79Jakub Kenig80Vladimir Khokha81Denis Khokha82Jae Il Kim83Victor Kong84Dimitris Korkolis85Vitor F. Kruger86Ashok Kshirsagar87Romeo Lages Simões88Andrea Lanaia89Konstantinos Lasithiotakis90Pedro Leão91Miguel León Arellano92Holger Listle93Andrey Litvin94Aintzane Lizarazu Pérez95Eudaldo Lopez-Tomassetti Fernandez96Eftychios Lostoridis97Davide Luppi98Gustavo M. Machain V99Piotr Major100Dimitrios Manatakis101Marianne Marchini Reitz102Athanasios Marinis103Daniele Marrelli104Aleix Martínez-Pérez105Sanjay Marwah106Michael McFarlane107Mirza Mesic108Cristian Mesina109Nickos Michalopoulos110Evangelos Misiakos111Felipe Gonçalves Moreira112Ouadii Mouaqit113Ali Muhtaroglu114Noel Naidoo115Ionut Negoi116Zane Nikitina117Ioannis Nikolopoulos118Gabriela-Elisa Nita119Savino Occhionorelli120Iyiade Olaoye121Carlos A. Ordoñez122Zeynep Ozkan123Ajay Pal124Gian M. Palini125Kyriaki Papageorgiou126Dimitris Papagoras127Francesco Pata128Michał Pędziwiatr129Jorge Pereira130Gerson A. Pereira Junior131Gennaro Perrone132Tadeja Pintar133Magdalena Pisarska134Oleksandr Plehutsa135Mauro Podda136Gaetano Poillucci137Martha Quiodettis138Tuba Rahim139Daniel Rios-Cruz140Gabriel Rodrigues141Dmytry Rozov142Boris Sakakushev143Ibrahima Sall144Alexander Sazhin145Miguel Semião146Taanya Sharda147Vishal Shelat148Giovanni Sinibaldi149Dmitrijs Skicko150Matej Skrovina151Dimitrios Stamatiou152Marco Stella153Marcin Strzałka154Ruslan Sydorchuk155Ricardo A. Teixeira Gonsaga156Joel Noutakdie Tochie157Gia Tomadze158Lara Ugoletti159Jan Ulrych160Toomas Ümarik161Mustafa Y. Uzunoglu162Alin Vasilescu163Osborne Vaz164Andras Vereczkei165Nutu Vlad166Maciej Walędziak167Ali I. Yahya168Omer Yalkin169Tonguç U. Yilmaz170Ali Ekrem Ünal171Kuo-Ching Yuan172Sanoop K. Zachariah173Justas Žilinskas174Maurizio Zizzo175Vittoria Pattonieri176Gian Luca Baiocchi177Fausto Catena178Department of Surgery, Macerata HospitalDepartment of Surgery, College of Medicine and Health Sciences, UAE UniversityGlobal Alliance for Infections in SurgeryDepartment of General Surgery, Rambam Health Care CampusDepartment of Emergency Surgery, Bufalini HospitalDepartment of Emergency Surgery, Bufalini HospitalAbdominal Center, Department of Abdominal Surgery, Helsinki University Hospital Meilahti and University of HelsinkiGeneral, Acute Care, Abdominal Wall Reconstruction, and Trauma Surgery, Foothills Medical CentreAbdominal Center, Department of Abdominal Surgery, Helsinki University Hospital Meilahti and University of HelsinkiDepartment of Surgery, Macerata HospitalDepartment of Digestive Surgery and SSPC Research Unit, CHU Amiens-PicardieDepartment of Trauma ICU, IALCH, University of KwaZulu-NatalDepartment of General Surgery, University Hospital of Coventry & WarwickshireDepartment of Surgery, Mansoura University and Emergency HospitalDepartment of Gastrointestinal Surgery, University of Health Sciences, Elazig Training and Research HospitalDepartment of Surgery, College of Health Sciences, Obafemi Awolowo UniversityDepartment of Surgery, LAUTECH Teaching HospitalDepartment of Surgery, TSMU First University ClinicDepartment of General Surgery, Sakarya University Research and Educational HospitalDepartment of General Surgery, Hacettepe University HospitalDepartment of Surgical Oncology, King Fahad Medical CityDepartment of General Surgery, Istinye University Faculty of MedicineDepartment of Primary Care, Primary Health Care Centre of KissamosSurgical Department, UMHAT “Eurohospital”, Medical UniversityDepartment of Surgery, University Hospital Centre ZagrebCirurgia Geral, Centro Hospitalar Universitário da Cova da BeiraDepartment of General Surgery, Hadassah Medical CenterDepartment of Surgery, Saint Savvas Anticancer HospitalGeneral Surgery, Habib bougatfaDepartment of Surgery, Lumbini Medical College and Teaching Hospital Ltd.Department of General Surgery, Rambam Health Care CampusDepartment of Surgery, Hospital San Juan de Dios de La SerenaEmergency and General Surgery, SG BoscoSurgical Department and ICU Department, General Hospital of LarissaGeneral Surgery, Hospital Santo TomasDepartment of Surgery, Elias Emergency HospitalDipartimento Emergenza e Accettazione, Policlinico Umberto IDepartment of General and Emergency Surgery, ASST Monza - Ospedale San GerardoGeneral Surgery, South Warwickshire NHS Foundation TrustDepartment of General Surgery, Kuala Krai HospitalU.O. Chirurgia d’Urgenza Universitaria, Azienda Ospedaliero-Universitaria PisanaU.O.C. Chirurgia Generale, PO Santissima TrinitàUGC Cirugía General, Complejo Hospitalario de JaénU.O. Chirurgia d’Urgenza Universitaria, Azienda Ospedaliero-Universitaria PisanaDepartment of General and Emergency Surgery, Azienda Ospedaliera Policlinico Universitario Palermo “Paolo Giaccone”General Surgery, University of Health Sciences, Samsun Training and Research HospitalDepartment of Surgery, G. Da Saliceto HospitalDepartment of Surgery, Tianjin Nankai HospitalChirurgie Viscerale et d’Urgence, Centre Hospitalier Regional de PerpignanDepartment of Surgery, University Clinical Center TuzlaDepartment of Surgery, Kipshidze Central University HospitalDivision of Trauma and Acute Care Surgery, LAC+USC Medical CenterDepartment of Surgery, University Hospital Centre ZagrebDepartment of General Surgery, University Hospital of TraumaDepartment of Infectious Diseases, King Fahad Medical CityChirurgia Generale, Ospedale VersiliaDepartment of Surgery, San Carlo Borromeo HospitalDepartment of General Surgery, San SalvatoreDepartment of General and Emergency Surgery, Azienda Ospedaliera Policlinico Universitario Palermo “Paolo Giaccone”Division of Trauma Surgery, Hospital de Clinicas, University of CampinasDepartment of Abdominal Surgery, Vladimir City Clinical Hospital of Emergency MedicineDepartment of Surgery, University hospitalDepartment of General Surgery, Mansoura University HospitalDepartment of General Surgery, Miguel Servet2nd Department of Surgery, Aretaieion University Hospital, National and Kapodistrian University of AthensDepartment of Surgery, Hospital Universitário Terezinha de Jesus, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora (SUPREMA)Department of General Surgery, Karadeniz Technical UniversityDepartment of General Surgery, Government Medical College and HospitalDepartment of General and Thoracic Surgery, University Hospital of GiessenDivision of Trauma Surgery, Hospital de Clinicas, University of CampinasDepartment of General Surgery, University and Regional Hospital Center of BorgouChirurgische Abteilung, Landesklinikum HainburgIntensive Care Unit, Chernivtsi City Emergency Hospital4th Surgical Department, Medical School, Aristotle University of Thessaloniki, General Hospital “G. Papanikolaou”Department of General Surgery, Erzincan University HospitalDepartment of Faculty Surgery #1, Pirogov Russian National Research Medical UniversityDepartment of Surgery, SMS HospitalDepartment of Surgery, Hospital of Lithuanian University of Health Sciences Kaunas ClinicsFaculty of Medicine University of Belgrade Clinic for Surgery, University Clinical Center “Zvezdara”Department of General Surgery, Government Medical College and HospitalDepartment of General, Oncologic and Geriatric Surgery, Jagiellonian University Collegium MedicumDepartment of Emergency Surgery, City HospitalDepartment of Vascular Surgery, City HospitalDepartment of Surgery, Inje University Ilsan Paik HospitalTrauma and Acute Care Surgery, Edendale HospitalDepartment of Surgery, Saint Savvas Anticancer HospitalDivision of Trauma Surgery, Hospital de Clinicas, University of CampinasDepartment of Surgery, Krishna Hospital and Medical Research University KaradDepartament of General Surgery, Hospital Municipal de Governador Valadares, Vale do Rio Doce UniversityChirurgia d’Urgenza, Arcispedale Santa Maria Nuova IRCCSGeneral Surgery, Scarborough Hospital, York Teaching Hospital NHS FTCirurgia Geral, Hospital de Braga, Life and Health Sciences Research Institute, ICVS/3Bs, Universidade do MinhoGeneral and Digestive Surgery, Hospital Fundación Jimenez DiazGeneral, Visceral, Thoracic and Vascular Surgery, University Hospital GreifswaldDepartment of Surgical Disciplines, Regional Clinical Hospital, Immanuel Kant Baltic Federal UniversityCirugía general y del aparato digestivo, Hospital Universitario DonostiaGastrointestinal Surgery, Hospital Insular de Gran Canaria1st Department of Surgery, Kavala General HospitalDepartment of General and Emergency Surgery, ASMN Reggio EmiliaII Catedra de Clinica Quirúrgica, Hospital de Clinicas, Facultad de Ciencias Médicas, Universidad Nacional de Asunción2nd Department of General Surgery, Jagiellonian University Medical CollegeDepartment of Surgery, Athens Naval and Veterans HospitalDivision of Trauma and Acute Care Surgery, LAC+USC Medical CenterFirst Department of Surgery, Tzaneio General HospitalDepartment of General Surgery and Surgical Oncology, Policlinico Le Scotte, University of SienaDepartment of General and Digestive Surgery, Hospital Universitario Doctor PesetDepartment of General Surgery, Post-graduate Institute of Medical SciencesDepartment of Surgery, Radiology, Anaesthesia and Intensive Care, University Hospital of the West IndiesDepartment of Surgery, University Clinical Center TuzlaSecond Surgical Clinic, Emergency County Hospital of Craiova3rd Department of Surgery, Ahepa University Hospital3rd Department of Surgery, Attikon University HospitalDepartament of General Surgery, Hospital Municipal de Governador Valadares, Vale do Rio Doce UniversityDepartment of Surgery, Hassan IIDepartment of General Surgery, Sakarya University Research and Educational HospitalDepartment of Specialist Surgery, Port Shepstone Regional HospitalGeneral Surgery Department, Emergency Hospital of BucharestToxicology and Sepsis, Riga East University HospitalDepartment of General Surgery, Queen Elizabeth HospitalChirurgia generale, Sant’Anna (AUSL Reggio Emilia)U.O. Chirurgia d’Urgenza, Arcispedale S. Anna FerraraDepartment of Surgery, University of Ilorin Teaching HospitalDepartment of Surgery, Fundacion Valle del Lili - Universidad del ValleDepartment of General Surgery, University of Health Sciences, Elazig Training and Research HospitalDepartment of Surgery, King George’s Medical UniversityChirurgia Generale e d’Urgenza, Ospedale InfermiSurgical Oncology, University Hospital Heraclion CreteDepartment of General Surgery, General Hospital of TrikalaDepartment of Surgery, Sant’Antonio Abate HospitalDepartment of General and Emergency Surgery, University Hospital, University Hospital KrakówCirurgia Geral, Centro Hospitalar Tondela-ViseuMedicina, Base HospitalChirurgia d’Urgenza – Dipartimento Urgenza/Emergenza, AOU ParmaDepartment of Abdominal Surgery, UMC LjubljanaDepartment of Endoscopic, Metabolic and Soft Tissue Tumors Surgery, University HospitalSurgery Department, Chernivtsi City Emergency HospitalDepartment of General, Emergency and Robotic Surgery, San Francesco HospitalDepartment of Surgery, AO San Giovanni AddolorataDepartment of Surgery/Trauma, Hospital Santo TomásDepartment of Trauma ICU, IALCH, University of KwaZulu-NatalDepartment of Gastrointestinal Surgery, HGR1 IMSSDepartment of General Surgery, Kasturba Medical College, Manipal Academy of Higher EducationDepartment of General Surgery, Rambam Health Care CampusFirst Clinic of General Surgery, University Hospital St George/Medical University PlovdivChirurgie Générale et Viscérale, Hôpital d’instruction des Armées, Hôpital Principal de DakarDepartment of Faculty Surgery #1, Pirogov Russian National Research Medical UniversityCirurgia Geral, Centro Hospitalar Universitário da Cova da BeiraDepartment of General Surgery, Government Medical College and HospitalDepartment of General Surgery, Tan Tock Seng HospitalDepartment of Surgery, Fatebbenefratelli HospitalDepartment of Surgery (Department No. 10), Riga East Clinical University Hospital “Gaiļezers”Department of Surgery, Hospital and Oncological Centre Novy JicinGeneral Surgery, Heartlands HospitalDepartment of Surgery, San Carlo Borromeo HospitalDepartment of General Surgery, Polytrauma and Emergency Medicine, University Hospital of the Jagiellonian University Medical CollegeGeneral Surgery Department, Bukovinian State Medical UniversityTrauma and Emergency Surgery, Hospital Escola Padre AlbinoFaculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon and Department of Surgery and Anaesthesiology, Yaounde Central HospitalSurgery Department, Tbilisi State Medical UniversityChirurgia Generale, Ospedale Civile di GuastallaFirst Department of Surgery, Department of Abdominal, Thoracic Surgery and Traumatology, First Faculty of Medicine, Charles University and General University HospitalUpper Gastrointestinal Tract Surgery Department, North Estonia Medical CentreDepartment of General Surgery, Siirt State HospitalFirst Surgical Unit, “St. Spiridon” University Hospital Iasi, University of Medicine and Pharmacy “Grigore T. Popa”Renal Transplant and General Surgery, Manchester Royal InfirmaryDepartment of Surgery, Clinical Center University of PecsFirst Surgical Unit, “St. Spiridon” University Hospital Iasi, University of Medicine and Pharmacy “Grigore T. Popa”Department of General, Oncological, Metabolic and Thoracic Surgery, Military Institute of MedicineDepartment of Surgey, Zliten Teaching HospitalDepartment of General Surgery, Ankara University School of MedicineTransplantation Unıt, Acibadem Atakent HospitalDepartment of General Surgery, Ankara University School of MedicineDepartment of Surgery, Taipei Medical University HospitalDepartment of Surgery, Mosc Medical CollegeFaculty of Medicine University of Belgrade Clinic for Surgery, University Clinical Center “Zvezdara”Surgical Oncology Unit, Azienda Unità Sanitaria Locale - IRCCS di Reggio EmiliaEmergency Surgery Department, Maggiore Parma HospitalDepartment of Clinical and Experimental Sciences, University of BresciaEmergency Surgery Department, Maggiore Parma HospitalAbstract Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28–66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4–10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0–1, 22.7% for those who had scores of 2–3, 46.8% for those who had scores of 4–5, and 86.7% for those who have scores of 7–8. Conclusions The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.http://link.springer.com/article/10.1186/s13017-019-0253-2Acute peritonitisSource controlEarly warning scoreEmergency surgery |
| spellingShingle | Massimo Sartelli Fikri M. Abu-Zidan Francesco M. Labricciosa Yoram Kluger Federico Coccolini Luca Ansaloni Ari Leppäniemi Andrew W. Kirkpatrick Matti Tolonen Cristian Tranà Jean-Marc Regimbeau Timothy Hardcastle Renol M. Koshy Ashraf Abbas Ulaş Aday A. R. K. Adesunkanmi Adesina Ajibade Lali Akhmeteli Emrah Akın Nezih Akkapulu Alhenouf Alotaibi Fatih Altintoprak Dimitrios Anyfantakis Boyko Atanasov Goran Augustin Constança Azevedo Miklosh Bala Dimitrios Balalis Oussama Baraket Suman Baral Or Barkai Marcelo Beltran Roberto Bini Konstantinos Bouliaris Ana B. Caballero Valentin Calu Marco Catani Marco Ceresoli Vasileios Charalampakis Asri Che Jusoh Massimo Chiarugi Nicola Cillara Raquel Cobos Cuesta Luigi Cobuccio Gianfranco Cocorullo Elif Colak Luigi Conti Yunfeng Cui Belinda De Simone Samir Delibegovic Zaza Demetrashvili Demetrios Demetriades Ana Dimova Agron Dogjani Mushira Enani Federica Farina Francesco Ferrara Domitilla Foghetti Tommaso Fontana Gustavo P. Fraga Mahir Gachabayov Grelpois Gérard Wagih Ghnnam Teresa Giménez Maurel Georgios Gkiokas Carlos A. Gomes Ali Guner Sanjay Gupta Andreas Hecker Elcio S. Hirano Adrien Hodonou Martin Hutan Igor Ilaschuk Orestis Ioannidis Arda Isik Georgy Ivakhov Sumita Jain Mantas Jokubauskas Aleksandar Karamarkovic Robin Kaushik Jakub Kenig Vladimir Khokha Denis Khokha Jae Il Kim Victor Kong Dimitris Korkolis Vitor F. Kruger Ashok Kshirsagar Romeo Lages Simões Andrea Lanaia Konstantinos Lasithiotakis Pedro Leão Miguel León Arellano Holger Listle Andrey Litvin Aintzane Lizarazu Pérez Eudaldo Lopez-Tomassetti Fernandez Eftychios Lostoridis Davide Luppi Gustavo M. Machain V Piotr Major Dimitrios Manatakis Marianne Marchini Reitz Athanasios Marinis Daniele Marrelli Aleix Martínez-Pérez Sanjay Marwah Michael McFarlane Mirza Mesic Cristian Mesina Nickos Michalopoulos Evangelos Misiakos Felipe Gonçalves Moreira Ouadii Mouaqit Ali Muhtaroglu Noel Naidoo Ionut Negoi Zane Nikitina Ioannis Nikolopoulos Gabriela-Elisa Nita Savino Occhionorelli Iyiade Olaoye Carlos A. Ordoñez Zeynep Ozkan Ajay Pal Gian M. Palini Kyriaki Papageorgiou Dimitris Papagoras Francesco Pata Michał Pędziwiatr Jorge Pereira Gerson A. Pereira Junior Gennaro Perrone Tadeja Pintar Magdalena Pisarska Oleksandr Plehutsa Mauro Podda Gaetano Poillucci Martha Quiodettis Tuba Rahim Daniel Rios-Cruz Gabriel Rodrigues Dmytry Rozov Boris Sakakushev Ibrahima Sall Alexander Sazhin Miguel Semião Taanya Sharda Vishal Shelat Giovanni Sinibaldi Dmitrijs Skicko Matej Skrovina Dimitrios Stamatiou Marco Stella Marcin Strzałka Ruslan Sydorchuk Ricardo A. Teixeira Gonsaga Joel Noutakdie Tochie Gia Tomadze Lara Ugoletti Jan Ulrych Toomas Ümarik Mustafa Y. Uzunoglu Alin Vasilescu Osborne Vaz Andras Vereczkei Nutu Vlad Maciej Walędziak Ali I. Yahya Omer Yalkin Tonguç U. Yilmaz Ali Ekrem Ünal Kuo-Ching Yuan Sanoop K. Zachariah Justas Žilinskas Maurizio Zizzo Vittoria Pattonieri Gian Luca Baiocchi Fausto Catena Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study World Journal of Emergency Surgery Acute peritonitis Source control Early warning score Emergency surgery |
| title | Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study |
| title_full | Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study |
| title_fullStr | Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study |
| title_full_unstemmed | Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study |
| title_short | Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study |
| title_sort | physiological parameters for prognosis in abdominal sepsis pipas study a wses observational study |
| topic | Acute peritonitis Source control Early warning score Emergency surgery |
| url | http://link.springer.com/article/10.1186/s13017-019-0253-2 |
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