Alterations in Muscle Architecture: A Review of the Relevance to Individuals After Limb Salvage Surgery for Bone Sarcoma
Osteosarcoma and Ewing's sarcoma are the most common primary bone malignancies affecting children and adolescents. Optimal treatment requires a combination of chemotherapy and/or radiation along with surgical removal when feasible. Advances in multiple aspects of surgical management have allowe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2020.00292/full |
| _version_ | 1811331820430557184 |
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| author | Christa M. Nelson Victoria Marchese Kelly Rock Robert M. Henshaw Robert M. Henshaw Odessa Addison Odessa Addison |
| author_facet | Christa M. Nelson Victoria Marchese Kelly Rock Robert M. Henshaw Robert M. Henshaw Odessa Addison Odessa Addison |
| author_sort | Christa M. Nelson |
| collection | DOAJ |
| description | Osteosarcoma and Ewing's sarcoma are the most common primary bone malignancies affecting children and adolescents. Optimal treatment requires a combination of chemotherapy and/or radiation along with surgical removal when feasible. Advances in multiple aspects of surgical management have allowed limb salvage surgery (LSS) to supplant amputation as the most common procedure for these tumors. However, individuals may experience significant impairment after LSS, including deficits in range of motion and strength that limit function and impact participation in work, school, and the community, ultimately affecting quality of life. Muscle force and speed of contraction are important contributors to normal function during activities such as gait, stairs, and other functional tasks. Muscle architecture is the primary contributor to muscle function and adapts to various stimuli, including periods of immobilization-protected weightbearing after surgery. The impacts of LSS on muscle architecture and how adaptations may impact deficits within the rehabilitation period and into long-term survivorship is not well-studied. The purpose of this paper is to [1] provide relevant background on bone sarcomas and LSS, [2] highlight the importance of muscle architecture, its measurement, and alterations as seen in other relevant populations and [3] discuss the clinical relevance of muscle architectural changes and the impact on muscle dysfunction in this population. Understanding the changes that occur in muscle architecture and its impact on long-term impairments in bone sarcoma survivors is important in developing new rehabilitation treatments that optimize functional outcomes. |
| first_indexed | 2024-04-13T16:26:37Z |
| format | Article |
| id | doaj.art-3796d83a93eb4fca9712f0de92645f3c |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-13T16:26:37Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-3796d83a93eb4fca9712f0de92645f3c2022-12-22T02:39:43ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-06-01810.3389/fped.2020.00292480113Alterations in Muscle Architecture: A Review of the Relevance to Individuals After Limb Salvage Surgery for Bone SarcomaChrista M. Nelson0Victoria Marchese1Kelly Rock2Robert M. Henshaw3Robert M. Henshaw4Odessa Addison5Odessa Addison6Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Orthopedic Oncology, MedStar Georgetown Orthopedic Institute, Washington, DC, United StatesDepartment of Orthopedic Oncology, Children's National Medical Center, Washington, DC, United StatesDepartment of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD, United StatesBaltimore VA GRECC, Baltimore, MD, United StatesOsteosarcoma and Ewing's sarcoma are the most common primary bone malignancies affecting children and adolescents. Optimal treatment requires a combination of chemotherapy and/or radiation along with surgical removal when feasible. Advances in multiple aspects of surgical management have allowed limb salvage surgery (LSS) to supplant amputation as the most common procedure for these tumors. However, individuals may experience significant impairment after LSS, including deficits in range of motion and strength that limit function and impact participation in work, school, and the community, ultimately affecting quality of life. Muscle force and speed of contraction are important contributors to normal function during activities such as gait, stairs, and other functional tasks. Muscle architecture is the primary contributor to muscle function and adapts to various stimuli, including periods of immobilization-protected weightbearing after surgery. The impacts of LSS on muscle architecture and how adaptations may impact deficits within the rehabilitation period and into long-term survivorship is not well-studied. The purpose of this paper is to [1] provide relevant background on bone sarcomas and LSS, [2] highlight the importance of muscle architecture, its measurement, and alterations as seen in other relevant populations and [3] discuss the clinical relevance of muscle architectural changes and the impact on muscle dysfunction in this population. Understanding the changes that occur in muscle architecture and its impact on long-term impairments in bone sarcoma survivors is important in developing new rehabilitation treatments that optimize functional outcomes.https://www.frontiersin.org/article/10.3389/fped.2020.00292/fullbone sarcomalimb salvage surgerymuscle architecturelower extremitymuscle adaptationultrasound |
| spellingShingle | Christa M. Nelson Victoria Marchese Kelly Rock Robert M. Henshaw Robert M. Henshaw Odessa Addison Odessa Addison Alterations in Muscle Architecture: A Review of the Relevance to Individuals After Limb Salvage Surgery for Bone Sarcoma Frontiers in Pediatrics bone sarcoma limb salvage surgery muscle architecture lower extremity muscle adaptation ultrasound |
| title | Alterations in Muscle Architecture: A Review of the Relevance to Individuals After Limb Salvage Surgery for Bone Sarcoma |
| title_full | Alterations in Muscle Architecture: A Review of the Relevance to Individuals After Limb Salvage Surgery for Bone Sarcoma |
| title_fullStr | Alterations in Muscle Architecture: A Review of the Relevance to Individuals After Limb Salvage Surgery for Bone Sarcoma |
| title_full_unstemmed | Alterations in Muscle Architecture: A Review of the Relevance to Individuals After Limb Salvage Surgery for Bone Sarcoma |
| title_short | Alterations in Muscle Architecture: A Review of the Relevance to Individuals After Limb Salvage Surgery for Bone Sarcoma |
| title_sort | alterations in muscle architecture a review of the relevance to individuals after limb salvage surgery for bone sarcoma |
| topic | bone sarcoma limb salvage surgery muscle architecture lower extremity muscle adaptation ultrasound |
| url | https://www.frontiersin.org/article/10.3389/fped.2020.00292/full |
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