Clinical Efficacy of Temocillin Standard Dosing in Patients Treated with Outpatient Antimicrobial Therapy
In 2020, EUCAST introduced breakpoints for temocillin. Based on these guidelines, reporting of temocillin susceptibility of <i>Enterobacterales</i> in the context of complicated urinary tract infections (cUTI) implicates the use of a high dose of temocillin (2 g q8h) constantly. We aimed...
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MDPI AG
2022-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/11/2289 |
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| author | Evelyne Van den Broucke Lore Thijs Stefanie Desmet Lotte Vander Elst Matthias Gijsen Marnix Mylemans Otto Van de Gaer Willy E. Peetermans Charlotte Quintens Isabel Spriet |
| author_facet | Evelyne Van den Broucke Lore Thijs Stefanie Desmet Lotte Vander Elst Matthias Gijsen Marnix Mylemans Otto Van de Gaer Willy E. Peetermans Charlotte Quintens Isabel Spriet |
| author_sort | Evelyne Van den Broucke |
| collection | DOAJ |
| description | In 2020, EUCAST introduced breakpoints for temocillin. Based on these guidelines, reporting of temocillin susceptibility of <i>Enterobacterales</i> in the context of complicated urinary tract infections (cUTI) implicates the use of a high dose of temocillin (2 g q8h) constantly. We aimed to evaluate the clinical outcome of patients treated with the standard dose (4 g/day) of temocillin in outpatient parenteral antimicrobial therapy (tOPAT). Demographics, clinical and treatment parameters, and late clinical cure (at day 30 after tOPAT completion) were recorded. Univariate generalised estimating equation analyses, with clinical cure as outcome variable, were performed to evaluate covariate associations. Fifty-seven tOPAT episodes in 50 patients were included with a median antimicrobial treatment duration of 21 (range 10–228) days, and cUTI was the main indication (87.7%). Late clinical cure was achieved in 85.7% of the tOPAT episodes. Non-disseminated infections and minimal inhibitory concentrations (MIC) values ≤ 8 mg/L were associated with good late clinical outcome. In conclusion, a standard temocillin dose (4 g/day) results in good clinical outcomes in the treatment of cUTIs in tOPAT patients. Therefore, our centre concluded that the use of standard temocillin dosing should be continued instead of the high dose for cUTI in non-critically ill patients infected with <i>Enterobacterales</i> with an MIC ≤ 4 mg/L. |
| first_indexed | 2024-03-09T18:44:51Z |
| format | Article |
| id | doaj.art-3798dedcf4154a13938eeee190494b5d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T18:44:51Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3798dedcf4154a13938eeee190494b5d2023-11-24T06:19:44ZengMDPI AGPharmaceutics1999-49232022-10-011411228910.3390/pharmaceutics14112289Clinical Efficacy of Temocillin Standard Dosing in Patients Treated with Outpatient Antimicrobial TherapyEvelyne Van den Broucke0Lore Thijs1Stefanie Desmet2Lotte Vander Elst3Matthias Gijsen4Marnix Mylemans5Otto Van de Gaer6Willy E. Peetermans7Charlotte Quintens8Isabel Spriet9Pharmacy Department, University Hospitals Leuven, 3000 Leuven, BelgiumPharmacy Department, University Hospitals Leuven, 3000 Leuven, BelgiumClinical Department of Laboratory Medicine, University Hospitals Leuven, 3000 Leuven, BelgiumPharmacy Department, University Hospitals Leuven, 3000 Leuven, BelgiumPharmacy Department, University Hospitals Leuven, 3000 Leuven, BelgiumClinical Department of Laboratory Medicine, University Hospitals Leuven, 3000 Leuven, BelgiumClinical Department of Laboratory Medicine, University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, BelgiumPharmacy Department, University Hospitals Leuven, 3000 Leuven, BelgiumPharmacy Department, University Hospitals Leuven, 3000 Leuven, BelgiumIn 2020, EUCAST introduced breakpoints for temocillin. Based on these guidelines, reporting of temocillin susceptibility of <i>Enterobacterales</i> in the context of complicated urinary tract infections (cUTI) implicates the use of a high dose of temocillin (2 g q8h) constantly. We aimed to evaluate the clinical outcome of patients treated with the standard dose (4 g/day) of temocillin in outpatient parenteral antimicrobial therapy (tOPAT). Demographics, clinical and treatment parameters, and late clinical cure (at day 30 after tOPAT completion) were recorded. Univariate generalised estimating equation analyses, with clinical cure as outcome variable, were performed to evaluate covariate associations. Fifty-seven tOPAT episodes in 50 patients were included with a median antimicrobial treatment duration of 21 (range 10–228) days, and cUTI was the main indication (87.7%). Late clinical cure was achieved in 85.7% of the tOPAT episodes. Non-disseminated infections and minimal inhibitory concentrations (MIC) values ≤ 8 mg/L were associated with good late clinical outcome. In conclusion, a standard temocillin dose (4 g/day) results in good clinical outcomes in the treatment of cUTIs in tOPAT patients. Therefore, our centre concluded that the use of standard temocillin dosing should be continued instead of the high dose for cUTI in non-critically ill patients infected with <i>Enterobacterales</i> with an MIC ≤ 4 mg/L.https://www.mdpi.com/1999-4923/14/11/2289temocillindosingEUCASTMICOPAT at home |
| spellingShingle | Evelyne Van den Broucke Lore Thijs Stefanie Desmet Lotte Vander Elst Matthias Gijsen Marnix Mylemans Otto Van de Gaer Willy E. Peetermans Charlotte Quintens Isabel Spriet Clinical Efficacy of Temocillin Standard Dosing in Patients Treated with Outpatient Antimicrobial Therapy Pharmaceutics temocillin dosing EUCAST MIC OPAT at home |
| title | Clinical Efficacy of Temocillin Standard Dosing in Patients Treated with Outpatient Antimicrobial Therapy |
| title_full | Clinical Efficacy of Temocillin Standard Dosing in Patients Treated with Outpatient Antimicrobial Therapy |
| title_fullStr | Clinical Efficacy of Temocillin Standard Dosing in Patients Treated with Outpatient Antimicrobial Therapy |
| title_full_unstemmed | Clinical Efficacy of Temocillin Standard Dosing in Patients Treated with Outpatient Antimicrobial Therapy |
| title_short | Clinical Efficacy of Temocillin Standard Dosing in Patients Treated with Outpatient Antimicrobial Therapy |
| title_sort | clinical efficacy of temocillin standard dosing in patients treated with outpatient antimicrobial therapy |
| topic | temocillin dosing EUCAST MIC OPAT at home |
| url | https://www.mdpi.com/1999-4923/14/11/2289 |
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