Local Net Charge State of Collagen Triple Helix Is a Determinant of FKBP22 Binding to Collagen III

Local Net Charge State of Collagen Triple Helix Is a Determinant of FKBP22 Binding to Collagen III

Mutations in the <i>FKBP14</i> gene encoding the endoplasmic reticulum resident collagen-related proline isomerase FK506 binding protein 22 kDa (FKBP22) result in kyphoscoliotic Ehlers–Danlos Syndrome (EDS), which is characterized by a broad phenotypic outcome. A plausible explanation fo...

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Bibliographic Details
Main Authors: Yoshihiro Ishikawa, Arkadiusz Bonna, Douglas B. Gould, Richard W. Farndale
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
endoplasmic reticulum
extracellular matrix
Ehlers–Danlos Syndrome
collagen Toolkit
triple-helical peptides
Online Access:https://www.mdpi.com/1422-0067/24/20/15156

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