Are Molecular Alterations Linked to Genetic Instability Worth to Be Included as Biomarkers for Directing or Excluding Melanoma Patients to Immunotherapy?

Are Molecular Alterations Linked to Genetic Instability Worth to Be Included as Biomarkers for Directing or Excluding Melanoma Patients to Immunotherapy?

The improvement of the immunotherapeutic potential in most human cancers, including melanoma, requires the identification of increasingly detailed molecular features underlying the tumor immune responsiveness and acting as disease-associated biomarkers. In recent past years, the complexity of the im...

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Bibliographic Details
Main Authors: Giuseppe Palmieri, Carla Maria Rozzo, Maria Colombino, Milena Casula, Maria Cristina Sini, Antonella Manca, Marina Pisano, Valentina Doneddu, Panagiotis Paliogiannis, Antonio Cossu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
melanoma
microsatellite instability
aneuploidy
tumor mutation burden
immunotherapy response
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.666624/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.666624/full

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